Information about the Project

Prof. Dr. med. Andreas Draguhn


Inst. for Physiology and Pathophysiology
Dpt. of Neurophysiology
Universität Heidelberg
Im Neuenheimer Feld 326
69120 Heidelberg

Tel.: +49-6221-544056
Fax.: +49-6221-546364

Link to the email:

Link to the lab page

Prof. Dr. rer. nat. Martin Korte

Zoological Institute
Div. of Cellular Neurobiology
TU Braunschweig
Spielmannstr. 7
38106 Braunschweig

Tel.: +49-531-391-3220
Fax: +49-531-391-3222

Link to the email:

Link to the lab page


Publications - TP6

Zhang XM, Herrmann U, Weyer SW, Müller UC, Korte M, Draguhn A. (2013) Hippocampal network oscillations in APP/APLP2-deficient mice. PLoS One, accepted.


Bähner F, Weiss EK, Birke G, Maier N, Schmitz D, Rudolph U, Frotscher M, Traub RD, Both M, Draguhn A (2011) Cellular correlate of assembly formation in oscillating hippocampal networks in vitro. PNAS 108:E607-616.


Korte M, Herrmann U, Zhang X, Draguhn A (2011) The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models. Exp Brain Res. Oct 18. [Epub ahead of print]


Delekate A, Zagrebelsky M, Kramer S, Schwab ME, Korte M (2011) NogoA restricts synaptic plasticity in the adult hippocampus on a fast time scale. Proc Natl Acad Sci USA 108:2569-2574.


Scheffzük C, Kukushka VI, Vyssotski AL, Draguhn A, Tort AB, Brankačk J. Selective coupling between theta phase and neocortical fast gamma oscillations during REM-sleep in mice. PLoS One. 2011;6(12):e28489.


Sajikumar S, Korte M (2011) Metaplasticity governs compartmentalization of synaptic tagging and capture through brain-derived neurotrophic factor (BDNF) and protein kinase Mzeta (PKMzeta). Proc Natl Acad Sci USA 108:2551-2556.


Weyer SW, Klevanski M, Delekate A, Voikar V, Aydin D, Hick M, Filippov M, Drost N, Schaller KL, Saar M, Vogt MA, Gass P, Samanta A, Jaschke A, Korte M, Wolfer DP, Caldwell JH, Müller UC (2011) APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. EMBO J 30: 2266-2280


Navakkode S, Korte M (2011) Cooperation between cholinergic and glutamatergic receptors are essential to induce BDNF-dependent long-lasting memory storage. Hippocampus Jan 20. doi: 10.1002/hipo.20902. [Epub ahead of print].


Sajikumar S, Korte M (2011) Different compartments of apical CA1 dendrites have different plasticity thresholds for expressing synaptic tagging and capture. Learning & Memory, in press.


Bertsche A, Bruehl C, Pietz J, Draguhn A (2010) Region- and pattern-specific effects of glutamate uptake blockers on epileptiform activity in rat brain slices. Epilepsy Res. 88: 118-126.


Birke G, Draguhn A (2010) No simple brake--the complex functions of inhibitory synapses. Pharmacopsychiatry. Suppl 1: S21-S31.


Brankack J, Kukushka VI, Vyssotski AL, Draguhn A (2010) EEG gamma frequency and sleep-wake scoring in mice: comparing two types of supervised classifiers. Brain Res. 1322:59-71.


Holter NI, Zylla MM, Zuber N, Bruehl C, Draguhn A (2010) Tonic GABAergic control of mouse dentate granule cells during postnatal development.Eur J Neurosci. 32: 1300-1309.


Michaelsen K, Zagrebelsky M, Berndt-Huch J, Polack M, Buschler A, Sendtner M, Korte M (2010) Neurotrophin receptors TrkB.T1 and p75(NTR) cooperate in modulating both functional and structural plasticity in mature hippocampal neurons. Eur J Neurosci 32:1854-1865.


Michaelsen K, Murk K, Zagrebelsky M, Dreznjak A, Jockusch BM, Rothkegel M, Korte M (2010) Fine-tuning of neuronal architecture requires two profilin isoforms. Proc Natl Acad Sci USA 107:15780-15785.


Rauskolb S, Zagrebelsky M, Dreznjak A, Deogracias R, Matsumoto T, Wiese S, Erne B, Sendtner M, Schaeren-Wiemers N, Korte M, Barde YA (2010) Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth. J Neurosci 30:1739-1749.


Reichinnek S, Künsting T, Draguhn A, Both M (2010) Field potential signature of distinct multi-cellular activity patterns in the mouse hippocampus. J Neurosci., 30:15441-9.


Schweizer PA, Duhme N, Thomas D, Becker R, Zehelein J, Draguhn A, Bruehl C, Katus HA, Koenen M (2010) cAMP Sensitivity of HCN Pacemaker Channels Determines Basal Heart Rate But Is Not Critical for Autonomic Rate Control. Circ Arrhythm Electrophysiol. 3: 542-552.


Zagrebelsky M, Schweigreiter R, Bandtlow CE, Schwab ME, Korte M (2010) Nogo-A stabilizes the architecture of hippocampal neurons. J Neurosci 30:13220-13234.


Zlomuzica A, Reichinnek S, Maxeiner S, Both M, May E, Wörsdörfer P, Draguhn A, Willecke K, Dere E (2010) Deletion of connexin45 in mouse neurons disrupts one-trial object recognition and alters kainate-induced gamma-oscillations in the hippocampus. Physiol Behav. 101: 245-53.


Axmacher N, Draguhn A, Elger CE, Fell J (2009) Memory processes during sleep: beyond the standard consolidation theory. Cell Mol Life Sci 66:2285-2297.


Bertsche A, Bruehl C, Pietz J, Draguhn A (2009) Region- and pattern-specific effects of glutamate uptake blockers on epileptiform activity in rat brain slices. Epilepsy Res. 88:118-126.


Draguhn A, Both M (2009) Dancing neurons, complex beats. J Physiol.587: 5297.


Hermann D, Both M, Ebert U, Gross G, Schoemaker H, Draguhn A, Wicke K, Nimmrich V (2009) Synaptic transmission is impaired prior to plaque formation in amyloid precursor protein-overexpressing mice without altering behaviorally-correlated sharp wave-ripple complexes. Neuroscience 162:1081-1090.


Korte M (2009) Neuroscience. Bridging the gap and staying local. Science 324:1527-1528.


Korte M., Wie Kinder heute Lernen. Was die Wissenschaft über das kindliche Gehirn weiss, DVA, 2009 (2. und 3. Auflage 2010, TB bei Goldmann 2011)


Lopantsev V, Both M, Draguhn A (2009) Rapid plasticity at inhibitory and excitatory synapses in the hippocampus induced by ictal epileptiform discharges. Eur J Neurosci 29:1153-1164.


Sawallisch C, Berhorster K, Disanza A, Mantoani S, Kintscher M, Stoenica L, Dityatev A, Sieber S, Kindler S, Morellini F, Schweizer M, Boeckers TM, Korte M, Scita G, Kreienkamp HJ (2009) The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. J Biol Chem 284:9225-9236.


Siegel G, Obernosterer G, Fiore R, Oehmen M, Bicker S, Christensen M, Khudayberdiev S, Leuschner PF, Busch CJ, Kane C, Hübel K, Dekker F, Hedberg C, Rengarajan B, Drepper C, Waldmann H, Kauppinen S, Greenberg ME, Draguhn A, Rehmsmeier M, Martinez J, Schratt GM (2009) A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol 11:705-716.


Teigler A, Komljenovic D, Draguhn A, Gorgas K, Just WW (2009) Defects in myelination, paranode organization and Purkinje cell innervation in the ether lipid-deficient mouse cerebellum. Hum Mol Genet 18:1897-1908.


Both M, Bähner F, von Bohlen und Halbach O, Draguhn A (2008) Propagation of specific network patterns through the mouse hippocampus. Hippocampus 18:899-908.


Draguhn A, Axmacher N, Kolbaev S (2008) Presynaptic ionotropic GABA receptors. Results Probl Cell Differ 44:69-85.


Grimm C, Holter NI, Draguhn A, Bruehl C (2008) Compensatory increase in P/Q-calcium current-mediated synaptic transmission following chronic block of N-type channels. Neurosci Lett 422:44-49.


Hartmann K, Bruehl C, Golovko T, Draguhn A (2008) Fast homeostatic plasticity of inhibition via activity-dependent vesicular filling. PLOS One 3:e2979.


Kolbaev S, Draguhn A (2008) Glutamine-induced membrane currents in cultured rat hippocampal neurons. Eur J Neurosci 28:535-545.


Korte M. Wie international ist Wissenschaft? Internationale Kooperationen in den Biowissenschaften. in: Wettlauf ums Wissen. Hrsg. G. Schütte, Berlin University Press, 2008.


Kreuzberg MM, Deuchars J, Weiss E, Schober A, Sonntag S, Wellershaus K, Draguhn A, Willecke K (2008) Expression of connexin30.2 in interneurons of the central nervous system in the mouse. Mol Cell Neurosci 37:119-34.


Korte M (2008) Neuroscience. A protoplasmic kiss to remember. Science 319:1627-1628.


Lahmann I, Fabienke M, Henneberg B, Pabst O, Vauti F, Minge D, Illenberger S, Jockusch BM, Korte M, Arnold HH (2008) The hnRNP and cytoskeletal protein raver1 contributes to synaptic plasticity. Exp Cell Res 314:1048-1060.


Matsumoto T, Rauskolb S, Polack M, Klose J, Kolbeck R, Korte M, Barde YA (2008) Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF. Nature Neuroscience 11:131-133.


Nimmrich V, Grimm C, Draguhn A, Barghorn S, Lehmann A, Schoemaker H, Hillen H, Gross G, Ebert U, Bruehl C (2008) Amyloid β oligomers (Aβ1-42 Globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents. J Neurosci 28:788-97.


Schrenk-Siemens K, Perez-Alcala S, Richter J, Lacroix E, Rahuel J, Korte M, Muller U, Barde YA, Bibel M (2008) Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmission. Stem Cells 26:2153-2163.


Weiss EK, Krupka N, Bähner F, Both M, Draguhn A (2008) Fast effects of glucocorticoids on memory-related hippocampal network oscillations in the mouse hippocampus. J Neuroendocrinol 20:549-557.


Deller T, Orth CB, Del TD, Vlachos A, Burbach GJ, Drakew A, Chabanis S, Korte M, Schwegler H, Haas CA, Frotscher M (2007) A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity. Ann Anat 189:5-16.


Holter NI, Zuber N, Bruehl C, Draguhn A (2007) Functional maturation of developing interneurons in the molecular layer of mouse dentate gyrus. Brain Res 1186:56-64.


Korte M. Neurobiologische Grundlagen unseres Bewusstsein. In: Hirnforschung und Menschenbild. Hrsg. A. Holderegger et al., Academic Press Fribourg, 2007.


Papadopoulos T, Korte M, Eulenburg V, Kubota H, Retiounskaia M, Harvey RJ, Harvey K, O'Sullivan GA, Laube B, Hulsmann S, Geiger JR, Betz H (2007) Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice. EMBO J 26:3888-3899.


Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Muller UC (2007) The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci 27:7817-7826.


Stief F, Zuschratter W, Hartmann K, Schmitz D, Draguhn A (2007) Enhanced synaptic excitation-inhibition ratio in hippocampal interneurons of rats with temporal lobe epilepsy. Eur J Neurosci 25:519-528.


Gartner A, Polnau DG, Staiger V, Sciarretta C, Minichiello L, Thoenen H, Bonhoeffer T, Korte M (2006) Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase Cgamma signaling. J Neurosci 26:3496-3504.


Kaltschmidt B, Ndiaye D, Korte M, Pothion S, Arbibe L, Prullage M, Pfeiffer J, Lindecke A, Staiger V, Israel A, Kaltschmidt C, Memet S (2006) NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling. Mol Cell Biol 26:2936-2946.


Lindecke A, Korte M, Zagrebelsky M, Horejschi V, Elvers M, Widera D, Prullage M, Pfeiffer J, Kaltschmidt B, Kaltschmidt C (2006) Long-term depression activates transcription of immediate early transcription factor genes: involvement of serum response factor/Elk-1. Eur J Neurosci 24:555-563.


Roth-Alpermann C, Morris RG, Korte M, Bonhoeffer T (2006) Homeostatic shutdown of long-term potentiation in the adult hippocampus. Proc Natl Acad Sci USA 103:11039-11044.



Selected publications 2005 and earlier:


Nimmrich V, Maier N, Schmitz D, Draguhn A (2005) Induced sharp wave-ripple complexes in the absence of synaptic inhibition in mouse hippocampal slices. J Physiol 563:663-670.


Zagrebelsky M, Holz A, Dechant G, Barde YA, Bonhoeffer T, Korte M (2005) The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons. J Neurosci 25:9989-9999.


Buzsaki G, Draguhn A (2004) Neuronal oscillations in cortical networks. Science 304:1926-1929.


Korte M*, Grunwald IC*, Adelmann G, Plueck A, Kullander K, Adams RH, Frotscher M, Bonhoeffer T, Klein R (2004) Hippocampal plasticity requires postsynaptic ephrinBs. Nature Neuroscience 7:33-40. *equal contribution


Maier N, Nimmrich V, Draguhn A (2003) Cellular and network mechanisms underlying spontaneous sharp wave-ripple complexes in mouse hippocampal slices. J Physiol 550:873-887.


Maier N, Guldenagel M, Sohl G, Siegmund H, Willecke K, Draguhn A (2002) Reduction of high-frequency network oscillations (ripples) and pathological network discharges in hippocampal slices from connexin 36-deficient mice. J Physiol 541:521-528.


Engel D, Pahner I, Schulze K, Frahm C, Jarry H, Ahnert-Hilger G, Draguhn A (2001) Plasticity of rat central inhibitory synapses through GABA metabolism. J Physiol 535:473-482.


Schmitz D, Schuchmann S, Fisahn A, Draguhn A, Buhl EH, Petrasch-Parwez E, Dermietzel R, Heinemann U, Traub RD (2001) Axo-axonal coupling. a novel mechanism for ultrafast neuronal communication. Neuron 31:831-840.


Draguhn A, Traub RD, Schmitz D, Jefferys JGR (1998) Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro. Nature 394:189-192.

Responsible: Email
Latest Revision: 2013-06-24
zum Seitenanfang/up