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Rennhack A, Jumpertz T, Ness J, Baches S, Pietrzik CU, Weggen S, Bulic B. (2012). Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells. Bioorg Med Chem. 2012 Nov 1;20(21):6523-32. doi: 10.1016/j.bmc.2012.08.034  Epub 2012 Aug 31. in process

 

 Jefferson T, Auf dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, Pietrzik CU, Postina R, Overall CM, Becker-Pauly C. (2012). The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10. Cell Mol Life Sci. 2013 Jan;70(2):309-33. doi: 10.1007/s00018-012-1106-2. Epub 2012 Sep 1.

  

Bien J, Jefferson T, Causević M, Jumpertz T, Munter L, Multhaup G, Weggen S, Becker-Pauly C, Pietrzik CU. (2012). The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species. J Biol Chem. 28;287(40):33304-13. Epub 9.

 

Zettl H, Ness J, Hähnke V, Beher D, Jumpertz T, Saric A, Baumann K, Pietrzik CU, Bulic B, Schneider G, Weggen S. (2012). Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening. ACS Chem Biol. 21;7(9):1488-95. Epub 2012 Jul 2. in process

 

Wagner S, Zensi A, Wien SL, Tschickardt SE, Maier W, Vogel T, Worek F, Pietrzik CU, Kreuter J, von Briesen H. (2012). Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model. PLoS One. 7(3)

 

Müller UC, Pietrzik CU, Deller T. (2012). The physiological functions of the β-amyloid precursor protein APP. Exp Brain Res. 217(3-4):325-9.

 

Pflanzner T, Petsch B, André-Dohmen B, Müller-Schiffmann A, Tschickardt S, Weggen S, Stitz L, Korth C, Pietrzik CU. (2012). Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier. J Cereb Blood Flow Metab. 32(4):628-32.

 

Jumpertz T, Rennhack A, Ness J, Baches S, Pietrzik CU, Bulic B, Weggen S. (2012).- Presenilin is the molecular target of acidic γ-secretase modulators in living cells. PLoS One. 7(1)

 

Isbert S, Wagner K, Eggert S, Schweitzer A, Multhaup G, Weggen S, Kins S, Pietrzik CU. (2012) APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms. Cell Mol Life Sci. 69(8):1353-75.

 

Wagner T, Pietrzik CU. (2012). The role of lipoprotein receptors on the physiological function of APP. Exp Brain Res. 217(3-4) 377-87. Review.

 

Jefferson T, Čaušević M, auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU, Becker-Pauly C. (2011). Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo. J Biol Chem. 286(31).

 

Heneka MT, Kummer MP, Weggen S, Bulic B, Multhaup G, Münter L, Hüll M, Pflanzner T, Pietrzik C.U.. (2011): Molecular Mechanisms and Therapeutic Application of NSAIDs and Derived Compounds in Alzheimer's Disease. Curr Alzheimer Res. Feb 23. [Epub ahead of print]

 

Hahn S, Brüning T, Ness J, Czirr E, Baches S, Gijsen H, Korth C, Pietrzik C.U., Bulic B, Weggen S. (2011): Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure. J Neurochem. Feb;116(3):385-95.

 

Rolyan H, Feike AC, Upadhaya AR, Waha A, Van Dooren T, Haass C, Birkenmeier G, Pietrzik C.U., Van Leuven F, Thal DR. (2011): Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease. J Neural Transm. Jan 6. [Epub ahead of print].

 

Pflanzner T, Kuhlmann CR, Pietrzik C.U. (2010): Blood-Brain-Barrier Models for the Investigation of Transporter- and Receptor-Mediated Amyloid-beta Clearance in Alzheimer's Disease. Curr Alzheimer Res. Nov;7(7):578-90.

 

Pflanzner T, Janko MC, André-Dohmen B, Reuss S, Weggen S, Roebroek AJ, Kuhlmann CR, Pietrzik C.U.. (2010): LRP1 mediates bidirectional transcytosis of amyloid-beta across the blood-brain barrier. Neurobiol Aging. 2010 Jul 12. [Epub ahead of print]

 

Kirschbaum KM, Uhr M, Holthoewer D, Namendorf C, Pietrzik C.U., Hiemke C, Schmitt U. (2010): Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice. Neuropharmacology Nov;59(6):474-9.

 

Reekmans SM, Pflanzner T, Gordts PL, Isbert S, Zimmermann P, Annaert W, Weggen S, Roebroek AJ, Pietrzik C.U. (2010): Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis. Cell Mol Life Sci. 135-45.

 

Jäger S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik C.U. (2009): alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation. J Neurochem. 1369-82.

 

Kuhlmann CR, Librizzi L, Closhen D, Pflanzner T, Lessmann V, Pietrzik C.U., de Curtis M, Luhmann HJ. (2009): Mechanisms of C-reactive protein-induced blood-brain barrier disruption. Stroke. Apr;40(4):1458-66.

 

Tamboli I, Prager K, Thal D, Thelen K, Dewachter I, Pietrzik C.U., St. George-Hyslop P, Sisodia S, DeStrooper B, Heneka M, Filippov M, Müller U, Van Leuven F, Lütjohann D, Walter J 2008: Loss of γ-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. J. Neurosci. Nov 12;28(46):12097-106.

 

Utter S, Tamboli IY, Walter J, Upadhaya AR, Birkenmeier G, Pietrzik C.U., Ghebremedhin E, Thal DR. 2008: Cerebral Small Vessel Disease induced Apolipoprotein E leakage is associated with Alzheimer Disease and the accumulation of Amyloid β-Protein in Perivascular Astrocytes. J. Neuropathol. Exp. Neurol. Sep;67(9):842-856.

 

Waldron E, Isbert S, Kern A, Jaeger S, Martin AM, Hébert SS, Behl C, Weggen S, De Strooper B, Pietrzik C.U. 2008: Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription. Exp Cell Res. Aug 1;314(13):2419-33. Epub 2008 May 17.

 

Waldron E, Heilig C, Schweitzer A, Nadella N, Jaeger S, Martin AM, Weggen S, Brix K, Pietrzik C.U. 2008: LRP1 modulates APP trafficking along early compartments of the secretory pathway. Neurobiol. Dis. Aug;31(2):188-97. Epub 2008 May 3.

 

Czirr E, Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik C.U., Golde TE, Wiltfang J, Baumann K, Koo EH, Weggen S. 2008: Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase. J. Biol. Chem. Jun 20;283(25):17049-54. Epub 2008 Apr 21.

 

Leuchtenberger S, Maler J, Czirr E, Ness J, Lichtenthaler SF, Esselmann H, Pietrzik C.U., Wiltfang J, Weggen S. 2008: Nonsteroidal Anti-Inflammatory Drugs and Ectodomain Shedding of the Amyloid Precursor Protein. Neurodegener Dis. Mar 18.

 

Martin A, Jaeger S, Kuhlmann C, Roebroek A, Luhmann H, Laatsch A, Weggen S, Lessmann V, Pietrzik C.U.2008: The functional role of LRP1 in tissue plasminogen activator mediated activation of the NMDA receptor. J. Biol. Chem. May 2;283(18):12004-13.

 

Jaeger S and Pietrzik C.U. 2008: Functional role of lipoprotein receptors in Alzheimer's disease. Curr Alzheimer Res. Feb;5(1):15-25.

 

Czirr E, Leuchtenberger S, Dorner-Ciossek C, Fleissner S, Schneider A, Jucker M, Koo EH, Pietrzik C.U., Baumann K, Weggen S 2007: Insensitivity to Aβ42-lowering non-steroidal anti-inflammatory drugs (NSAIDs) and γ-secretase inhibitors is common among aggressive presenilin-1 mutations. J. Biol. Chem. Aug 24;282(34):24504-13.

 

Ring S, Weyer S, Kilian S, Waldron E, Pietrzik C.U., Filippov M, Herms J, Eckman CB, Korte M, Wolfer DP, Müller U 2007: The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neuroscience Jul 18;27(29):7817-26.

 

Waldron E, Jaeger S, Pietrzik C.U. 2006: Functional role of the low-density lipoprotein receptor-related protein in Alzheimer's disease. Neurodegenerative Dis. 2006;3(4-5):233-8.

 

Neumann S, Schöbel S, Jäger S, Haass C, Pietrzik C.U., Lichtenthaler SF 2006: APLP1 influences endocytosis and proteolytic processing of the amyloid precursor protein. J. Biol. Chem. Mar 17;281(11):7583-94.

 

Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Sagi SA, Berdeaux R, Pietrzik C.U., Golde T, Koo EH, Weggen S 2006: Inhibitors of the Rho-effector Rho-kinase (ROCK) modulate amyloid-β (Aβ) secretion but lack selectivity for Aβ42. J. Neurochem. Jan;96(2):355-65.

 

 

Selected publications 2005 and earlier:

  

Lleo A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik C.U.*, Berezovska O.*. 2005: Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. J. Biol. Chem. 22;280(29):27303-9. (*authors contributed equally to this work).

 

Yoon I.S., Pietrzik C.U., Kang DE, Koo EH. 2005: Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling. J. Biol. Chem. 20;280(20):20140-7.

 

Goodenough S., Schleusner D., Pietrzik C.U. and Behl C. 2005: Glycogen Synthase kinase 3β links neuroprotection by 17β-estradiol to key Alzheimer processes. Neuroscience, 132(3):581-9.

 

Pietrzik C.U. and Behl C 2005: Concepts for the treatment of Alzheimer's disease: molecular mechanisms and clinical application. Int. J. Exp. Pathol. 86(3):173-85.

 

Pietrzik C.U., Yoon I-S., Jaeger S., Busse T., Weggen S. and Koo E.H. 2004: FE65 constitutes the functional link between the LDL receptor-related protein (LRP) and the amyloid precursor protein (APP). J. Neuroscience, 24(17):4259-65

 

Weggen S, Eriksen JL, Sagi SA, Pietrzik C.U., Ozols V, Fauq A, Golde TE, Koo EH. 2003: Evidence that nonsteroidal anti-inflammatory drugs decrease Abeta 42 production by direct modulation of gamma-secretase activity. J. Biol. Chem. 278(34):31831-7.

 

Weggen S, Eriksen JL, Sagi SA, Pietrzik C.U., Golde TE, Koo EH. 2003: A beta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein and ErbB-4 receptor and signaling through the APP intracellular domain. J. Biol. Chem. 278(33):30748-54.

 

Pietrzik C.U., Busse T., Merriam D.E., Weggen S. and Edward H. Koo. 2002: The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in amyloid precursor protein processing. EMBO J. 21(21):5691-700.

 

Leem J.Y., Saura C.A., Pietrzik C.U., Christianson J., Wanamaker C., King L.T., Veselits M.L., Tomita T., Gasparini L., Iwatsubo T., Xu H., Green W.N., Koo, E.H. and G. Thinakaran 2002: A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol. Disease. Oct;11(1):64-82.

 

Weggen S., Eriksen J.L., Das P., Sagi S.A., Wang R., Pietrzik C.U., Findlay K.A., Smith T.E., Murphy M.P., Bulter T., Kang D.E., Marquez-Sterling N., Golde T.E. and E.H. Koo. 2001: A subset of NSAIDs lower amyloidogenic Aβ42 independent of COX activity. Nature, 414:212-216

 

Soriano S., Lu D., Chandra S., Pietrzik C.U. and E.H. Koo 2001: The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases. J. Biol. Chem. 276(31): 29045-50.

 

Kang D.E.*, Pietrzik C.U.*, Baum L., Chevallier N., Merriam D.E., Kounnas M.Z., Wagner S.L., Troncoso J.C., Kawas C.H., Katzman R. and E.H. Koo 2000: Modulation of amyloid β-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. J. Clin. Invest. 106(9):1159-1166. (*authors contributed equally to this work).