Prof. Dr. Bernd Bukau

1954 born in Leipzig

Curriculum Vitae

1974-80
Universität Konstanz. Biology, Diplom 1980, 1977 University of California, Santa Cruz (USA) Research stage

1983-86
Universität Konstanz. Doctoral work, Dr. rer. nat.

1986-89
Massachusetts Institute of Technology, Cambridge, (USA). Postdoctoral fellow

1989-97
ZMBH, Heidelberg University. Research assistant and project leader

1994
Habilitation and appointment as lecturer for Microbiology and Molecular Biology at the Heidelberg University

1997-02
C4-Professor for Biochemistry at the University of Freiburg, Institute of Biochemistry and Molecular Biology, Faculty of Medicine

2000
Leibniz Prize (DFG); 2001 Elected EMBO member

2002
C4-Professor for Molecular Biology at the Heidelberg University, ZMBH

2002-04
Deputy Director of the ZMBH

2005
Research Prize and elected member of the Leopoldina

Since 2005
Director of the ZMBH

Fields of Interest

Molecular Biology and Biochemistry: Protein folding; molecular chaperones and proteases

Selected Publications

• Vogel, M., Bukau, B., Mayer, M.P. Allosteric regulation of Hsp70 chaperones by a proline switch. Mol. Cell (2006) 21, 359-367.
• Erbse, A., Schmidt, R., Bornemann, T., Schneider-Mergener, J., Mogk A., Zahn, R., Dougan, D.A., Bukau, B. ClpS is an essential component of the N-end rule pathway in Escherichia coli. Nature (2006) 439, 753-756.
• Bukau, B., Weissman, J., Horwich, A. Molecular Chaperones and Protein Quality Control. Cell (2006) 125, 443-451.
• Weibezahn, J., Tessarz, P., Schlieker, C., Zahn, R., Maglica, Z., Lee, S., Zentgraf, H., Weber-Ban, E., Dougan, D., Tsai, F.T.F., Mogk, A., Bukau, B. Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB. Cell (2004) 119, 653-665.
• Ferbitz, L., Maier, T., Patzelt, H., Bukau, B., Deuerling, E., Ban, N. Structure of the Trigger Factor chaperone complex with the ribosome defines the molecular environment of the emerging nascent protein chain. Nature (2004) 431, 590-596.
• Dougan, D.A., Weber-Ban, E., Bukau, B. Targeted delivery of an ssrA-tagged substrate by the adaptor protein SspB to its cognate AAA+ protein ClpX. Mol. Cell (2003) 12, 373-380.
• Kramer, G., Rauch, T., Rist, W., Vorderwülbecke, S., Patzelt, H., Schulze-Specking, A., Ban, N., Deuerling, E., Bukau, B. L23 protein functions as a chaperone docking site on the ribosome. Nature (2002) 419, 171-174.
• Dougan, D.A., Reid, B.G., Horwich, A.L., Bukau, B. ClpS, a substrate modulator of the ClpAP machine. Mol. Cell (2002) 9, 673-683.
• Mayer, M.P., Schröder, H., Rüdiger, S., Paal, K., Laufen, T., Bukau, B. Multistep mechanism of substrate binding determines chaperone activity of Hsp70. Nat. Struct. Biol. (2000) 7, 586-953.
• Deuerling, E., Schulze-Specking, A., Tomoyasu ,T., Mogk, A., Bukau, B. Trigger factor and DnaK cooperate in folding of newly synthesized proteins. Nature (1999) 400, 693-696.
• Bukau, B., Horwich, A.L. The Hsp70 and Hsp60 chaperone machines. Cell (1998) 92, 351-366.