Molecular anatomy of the developing neuromuscular junction
Veit Witzemann Department of Cellphysiology MPI for Medical Research Jahnstr. 29 69120 Heidelberg Germany
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Research Summary
The formation of the neuromuscular junction involves reciprocal interactions between the presynaptic nerve terminal and the postsynaptic muscle fiber. We generate genetically manipulated mouse models to modulate synaptic activity by changing the functional properties of the postsynaptic signaltransducers, the acetylcholine receptors (AChR) or by inactivating conditionally other synaptic regulators. These studies lead to the analysis of disorders that are caused by defective neuromuscular junctions.
Structure of the Group
Group Leader: | Veit Witzemann |
Postdoctoral fellows: | Frédéric Chevessier, Pessah Yamapolsky |
PhD-Students: | Pier-Giorgio Pacifici |
Undergraduates: | Ulrike Mersdorf, Susi Zobeley |
Editor:
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Latest Revision:
2013-03-06