Peer-reviewed publications

Search for Spanagel, R. publications on pubmedlogo

(since 2000)

Hölter SM, Danysz W, Spanagel R (2000) The non-competitive NMDA receptor antagonist MRZ 2/579 suppresses the alcohol deprivation effect in long-term alcohol drinking rats and substitutes the alcohol cue in a discrimination task. J Pharmacol Exp Ther, 292:545-52

Spanagel R, Hölter SM (2000) Pharmacological validation of a new animal model of alcoholism. J Neural Transm, 107:669-80

Platzer S, Winkler A, Dworzak D, Schadrack J, Tölle TR, Zieglgänsberger W, Spanagel R (2000) Autoradiographic distribution of µ-, δ and κ1-opioid stimulated [35S] GPT γ S-binding in human frontal cortex and cerebellum. Neurosci Lett, 66:143-51

Henniger MS, Ohl F, Hölter SM, Weißenbacher P, Toschi N, Löscher P, Wigger A, Spanagel R, Landgraf R. (2000) Unconditioned anxiety and social behaviour in two rat lines selectively bred for high and low anxiety-related behaviour. Behav Brain Res, 111:153-63

Hölter SM, Linthorst AC, Reul JH, Spanagel R (2000) Withdrawal symptoms in a long-term model of voluntary alcohol drinking in wistar rats. Pharmacol Biochem Behav, 66:143-51

Hölter SM, Henniger MS, Lipowski AW, Spanagel R (2000) Kappa-opioid receptors and relapse-like drinking in long-term ethanol-experienced rats. Psychopharmacology, 153:93-102

Spanagel R (2000) Recent animal models of alcoholism. Alcohol Research & Health, 24:124-31

Azad SC, Marsicano G, Eberlein I, Putzke J, Zieglgänsberger W, Spanagel R, Lutz B (2001) Differential role of the nitric oxide pathway on- Δ 9 THC-induced central nervous system effects in the mouse. Eur J Neurosci, 13:561-68

Rammes G, Mahal B, Putzke J, Parsons C, Spielmanns P, Pestel E, Spanagel R, Zieglgansberger W, Schadrack J (2001) The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801. Neuropharmacology, 40:749-60

Matsumoto I, Wilce PA, Buckley T, Dodd P, Putzke J, Spanagel R, Zieglgansberger W, Wolf G, Leng S, Rommelspacher H, Finck U, Schmidt LG (2001) Ethanol and gene expression in brain. Alcohol Clin Exp Res, 25:82-6

Li TK, Spanagel R, Colombo G, McBride WJ, Porrino LJ, Suzuki T, Rodd-Henricks ZA (2001) Alcohol reinforcement and voluntary ethanol consumption. Alcohol Clin Exp Res, 25:117–26

Boening JA, Lesch OM, Spanagel R, Wolffgramm J, Narita M, Sinclair D, Mason BJ, Wiesbeck GA (2001) Pharmacological relapse prevention in alcohol dependence: from animal models clinical trials. Alcohol Clin Exp Res, 25:127–31

Sillaber I, Rammes G, Zimmermann S, Mahal B, Zieglgänsberger W, Wurst W, Holsboer F, Spanagel R (2002) Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science, 296:931-33

Henniger MS, Spanagel R, Wigger S, Landgraf R, Hölter SM (2002) Alcohol self-administration in two Wistar rat lines selectively bred for extremes in anxiety-related behaviour. Neuropsychopharmacology, 26:729-36

Kirschke C, Schadrack J, Zieglgänsberger W, Spanagel R (2002) Effects of morphine withdrawal on µ-opioid receptor stimulated [35S]GTP gamma-S autoradiography in rat brain. Eur J Pharmacol, 446:43-51

Abarca C, Albrecht U, Spanagel R (2002) Cocaine sensitization and reward are influenced by circadian genes and rhythm. Proc Natl Acad Sci USA, 99:9026-30

Spanagel R, Sigmund S, Cowen M, Schroff KC, Schumann G, Fiserova M, Sillaber I, Wellek S, Singer MV, Putzke J (2002) The neuronal nitric oxide synthase (nNOS) gene is critically involved in neurobehavioral effects of alcohol. J Neurosci, 22:8676-83

Abarca C, Albrecht U, Spanagel R (2002) Cocaine sensitization and reward are influenced by circadian genes and rhythm. Proc Natl Acad Sci USA, 99:9026-30

Spanagel R, Sigmund S, Cowen M, Schroff KC, Schumann G, Fiserova M, Sillaber I, Wellek S, Singer MV, Putzke J (2002) The neuronal nitric oxide synthase (nNOS) gene is critically involved in neurobehavioral effects of alcohol. J Neurosci, 22:8676-83

Schumann G, Rujescu D, Singer P, Szegedi A, Wiemann S, Wellek S, Heinz A, Spanagel R, Mann K, Henn FA, Dahmen N (2003) No association of alcohol dependence with a NMDA-receptor 2 B gene variant. Mol Psychiatry, 8:11-12

Schumann G, Spanagel R, Mann K (2003) Candidate genes for alcohol dependence: new approaches, new genes. Alcohol Clin Exp Res, 27:1-9

Deroche-Gamonet V, Sillaber I, Aouizerate B, Izawa R, Jaber M, Ghozland S, Kellendonk C, Spanagel R, Le Moal M, Schütz G, Tronche F, Piazza PV. (2003) The Glucocorticoid receptor as potential target to reduce cocaine abuse. J Neurosci, 23:10-16

Spanagel R (2003) Alcohol addiction research: From animal models to clinics. Best Pract Res Cl GA, 17: 507-18

Kratzer U, Spanagel R, Schmidt WJ (2003) The effect of acamprosate on the development of morphine-induced behavioural sensitization. Behav Pharmacol, 14:351-356

Vengeliene V, Siegmund S, Singer MV, Sinclair JD, Li T-K, Spanagel R (2003) A comparative study on alcohol-preferring rat lines: Effects of deprivation and stress phases on voluntary alcohol intake. Alcohol Clin Exp Res, 27:1048-54

Cowen MS, Schroff KC, Sprengel R, Spanagel R (2003) Neurobehavioral effects of alcohol in AMPA receptor subunit (GluR1) deficient mice. Neuropharmacology, 45:325-33

Cowen M, Schumann G, Yagi, Spanagel R (2003) Role of Fyn tyrosine kinase in ethanol consumption by mice. Alcohol Clin Exp Res, 27:1213-219

Gass P, Andersen P, Hvalby O, Jensen V, Kvello A, Layer L, Spanagel R, Sprengel R, Strekalova T, Wagner E, Zacher C, Fleischmann A (2003) Brain-specific c-fos disruption causes deficits of long-term memory and synaptic plasticity by partial loss of NMDA receptor mediated signaling pathways. J Neurosci, 23:9116-122

Spanagel R, Sanchis-Segura C (2003) The use of transgenic mice to study additive behavior. Clin Neurosci Res, 3: 325-31

Schumann G, Kissling C, Preuss UW, Rujescu D, Dahmen N, Giegling I, Wieman S, Müller A, Wellek S, Lascorz J, Soyka M, Bondy B, Anghelescu I, Cowen MS, Poustka A, Spanagel R, Mann K, Henn FA, Szegedi A (2003) Analysis of genetic variations of Protein Tyrosine Kinase “fyn” and their association with alcohol dependence in two independent populations. Biol Psychiatry, 54:1422-26

Siegmund S, Spanagel R, M.V. Singer. (2003) Role of the brain-gut axis in alcohol-related gastrointestinal diseases – What can we learn from new animal models? J Physiol Pharmacol 54, 191-207

Bachteler D, Bäckström S, Koch S, Hyytiä P, Spanagel R (2004) The mGluR5 antagonist MPEP prevents alcohol seeking and relapse behavior. Neuropsychopharmacology 29, 921-928

Vollmayr B, Bachteler D, Vengeliene V, Gass P, Spanagel R, Henn FA (2004) Anhedonia and general behavioral measures in rats with congenital learned helplessness. Behav Brain Res 150, 217-221

Sanchis-Segura C, Cline BH, Marsicano G, Lutz B, Spanagel R (2004) Reduced sensitivity to reward and sucrose consumption in CB1 knockout mice. Psychopharmacology 176, 223-232

Littleton J, de Witte P, Litten R, Gessa GL, Spanagel R, Kranzler H, Lehert P, Johnson B, Saunders J, Berglund M, Harris A, Anton R, Mann K (2004) Challenges to medications development in alcoholism: an international perspective. Alcohol and Alcoholism 39, 271-275

Schroff KC, Cowen MS, Koch S, Spanagel R (2004) Strain specific responses of inbred mice to ethanol following food shortage. Addict Biol 9, 265-271

Strekalova T, Spanagel R, Bartsch D, Henn FA, Gass P (2004) Stress-induced anhedonia in mice is associated with deficits in copying and exploration. Neuropsychopharmacology 29, 2007-2017

Zink M, Schmitt A, Henn FA, Spanagel R (2004) Ethanol induces expression of glutamate transporters EAAT1 and EAAT2 in organotypic cortical slice cultures. Alcohol Clin Exp Res 28, 1752-1757

Werner C, Raivich G, Cowen M, Strekalova T, Sillaber I, Spanagel R, Hofmann F (2004) Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for mediating emotionality and neurobehavioral effects of alcohol. Eur J Neurosci 20, 3498-3506

Spanagel R, Pendyala G, Abarca C, Zghoul T, Sanchis-Segura, Magnone MC,Lascorz J, Depner M, Holzberg D, Soyka M, Schreiber S, Matsuda F, Lathrop M, Schumann G, Albrecht U (2005) The circadian clock gene Period2 alters the glutamatergic system and thereby modulates alcohol consumption. Nat Med 11, 35-42

Leonardi-Essmann F, Emig M, Kitamura Y, Spanagel R, Gebicke-Haerter PJ (2005) Fractalkine-upregulated milk-fat globule EGF factor-8 (MFG-E8) protein in cultured rat microglia. J Neuroimmunol 160, 92-101

Vengeliene V, Vollmayer B, Henn FA, Spanagel R (2005) Alcohol self-administration in two rat lines selectively bred for helplessness and non-helplessness behavior. Psychopharmacology 178,125-132

Zink M, Spanagel R (2005) Ethanol induces glutamic acid decarboxylase (GAD67) and the vesicular -amino-butyric acid transporter (VAGT) in organotypic cortical slice cultures. Neuroreport 16, 377-380 (1.995)

Bachteler D, Economidou D, Danysz W, Ciccocioppo R, Spanagel R. The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behaviour (2005) Neuropsychopharmacology, 30, 1104-1111

Vengeliene V, Bachteler D, Wojciech D, Spanagel R (2005) The role of the NMDA receptor complex in alcohol relapse: A pharmacological mapping study using the alcohol deprivation effect. Neuropharmacology 48, 822-829

Strekalova T, Spanagel R, Dolgov O, Bartsch D (2005) Stress-induced hyperlocomotion as a confounding factor in anxiety and depression models in mice. Behav Pharmacol 16,171-180

Siegmund S, Vengeliene V, Schroff K, Singer MV, Spanagel R (2005) Influence of age of drinking onset on long-term alcohol self-administration with deprivation and stress phases. Alcohol Clin Exp Res 29,1139-1145

Zueger M, Urani A, Chourbaji S, Abarca C, Zacher C, Strekalova T, Lipp HP, Albrecht U, Spanagel R, Wolfer DP, Gass P (2005) mPer1 and mPer2 mutant mice show regular spatial and contextual learning. J Neural Transm 15, 234-39

Sanchis-Segura C, R. Spanagel, Henn FA, Vollmayr (2005) Reduced sensitivity to sucrose in rats bred for helplessness: a study using the matching law. Behav Pharmacol 16, 267-270

Chourbaji S, Zacher C, Sanchis-Segura C, Spanagel R, Gass P. Social and environmental housing conditions influence the development of a depressive-like phenotype in the learned helplessness paradigm in mice. Behav Brain Res 14;164, 100-106

Spanagel R, Rosenwasser AM, Schumann G, Sarkar DK. Alcohol consumption and the body´s biological clock. Alcohol Clin Exp Res 29, 1550-1557

Spanagel R, Heilig M. Addiction and its brain science. Addiction 100, 1813-1822

Zieker D, Fehrenbach E, Dietzsch J, Fliegner J, Waidmann M, Nieselt K, Gebicke-Haerter P, Spanagel R, Simon P, Niess AN, Northoff H. cDNA-microarray analysis reveals novel candidate genes expressed in human peripheral blood following exhaustive exercise. Physiol Genomics 23, 287-94

Sanchis-Segura C, Borchardt T, Vengeliene V, Zghoul T, Bachteler D, Gass P, Sprengel R, Spanagel R. Involvement of AMPA receptor GluR-C subunit in alcohol-seeking and relapse. J Neurosci 26, 1231-1238 (7.506)

Treutlein J, Kissling C, Frank J, Wiemann S, Depner M, Saam C, Lascorz J, Wellek S, Soyka M, Spanagel R, Heinz A, Laucht M, Mann K, Schumann G (2006) Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. Mol Psychiatry 11, 594-602

Spanagel R (2006) Science meets public. Addict Biol 11, 1-2

Sanchis-Segura C, Spanagel R (2006) Behavioral assessment of drug-reinforcement and addictive features in rodents: an overview. Addict Biol 11, 2-36

Kiefer F, Spanagel R (2006) Measuring alcohol consumption in man – It´s time for a change. Addiction 101, 1214-15

Vengeliene V, Leonardi-Essmann F, Perreau-Lenz S, Gebicke-Haerter P, Drescher K, Gross G, Spanagel R (2006) The D3 receptor plays an essential role in alcohol craving and relapse but not in alcohol reinforcement processes. FASEB J 20:2223-2233

Sanchis-Segura C, Borchardt T, Vengeliene V, Zghoul T, Bachteler D, Gass P, Sprengel R, Spanagel R (2006) Involvement of AMPA receptor GluR-C subunit in alcohol-seeking and relapse. J Neurosci 26, 1231-1238

Zghoul T, Abarca C, Sanchis-Segura C, Albrecht U, Schumann G, Spanagel R (2007) Ethanol self-administration and reinstatement of ethanol-seeking behaviour in mPer1 mutant mice. Psychopharmacology 190, 13-9

Zieker J, Zieker D, Jatzko A, Dietzsch J, Nieslet K, Schmitt A, Bertsch T, Fassbender K, Spanagel R, Henn FA, Northoff H, Gebicke-Haerter P (2007) Differential gene expression in peripheral blood of patients suffering from posttraumatic stress disorder. Mol Psychiatry 12, 116-119

Spanagel R (2007) Neurobiology of addiction. Addiction 102, 492-495

Füllgrabe M, Vengeliene V, Spanagel R (2007) Influence of age at drinking onset on the alcohol deprivation effect and stress-induced drinking in female rats. Pharmacol Biochem Behav 86, 320-327

Sanchis-Segura C, Cline B, Jurd R, Rudolph U, Spanagel R (2007) Etomidate and propofol-insensitive mice carrying the ß3(N265M) mutation show little change in acute alcohol sensitivity but enhanced tolerance and withdrawal. Neurosci. Lett. 416, 275-278

Perreau-Lenz S, Zghoul T, Spanagel R (2007) Clock genes are ticking crazy: Implications for drug addiction and depression. EMBO Rep. 8, 20-24

Vengeliene V, Frank ST, Heidbreder CA, Spanagel R. The effect of lamotrigine on alcohol seeking and relapse. Neuropharmacology in press

Frank ST, Krumm B, Spanagel R. Cocaine-induced dopamine release into the nucleus accumbens measured by in vivo microdialysis: a meta-analysis. Synapse in press

Spanagel R, Kiefer F (2008) Drugs for Relapse Prevention of Alcoholism – 10 Years of Progress. Trends Pharmacol Sci 29,109-115

Hampp G, Ripperger JA, Houben T, Schmutz I, Blex C, Brunk I, Perreau-Lenz S, Spanagel R, Ahnert-Hilger G, Meijer J, Albrecht U (2008) Regulation of the murine monoamine oxidase A gene by circadian clock components implies clock influence on mood. Curr Biol 18, 678-683

Wiens F, Zitzmann A, Lachance MA, Yegeles M, Pragst F, Wurst FM, von Holst D, Guan SL, Spanagel R (2008) The missing drink: the bertam palm of West-Malaysis gets wild mammals to chronically consume alcohol. Proc Natl Acad Sci USA 105, 10426-31

Engblom D, Sanchis-Segura C, Bilbao-Leis A, Dahan L, Perreau-Lenz S, Balland B, Mameli M, Rodriguez Parkitna J, Parlato R, Sprengel R, Lüscher C, Schütz G, Spanagel R (2008) Glutamate receptors on dopaminergic neurons control the persistence of drug-seeking. Neuron 59, 497-508

Bilbao A, Rodriguez Parkitna J. Engblom D, Sanchis-Segura C, Perrau-Lenz S, Schneider M, Konopka W, Westphal M, Breen G, Desrivieres S, Klugmann M, Rodriguez de Fonseca F, Vallada H, Schumann G, Schütz G, Spanagel R (2008) Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Proc Natl Acad Sci USA [Epub ahead of print]

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