Mechanisms of neuronal polarity
Medizinische Fakultät Mannheim der Universität Heidelberg
Center for Biomedicine and Medical Technology Mannheim (CBTM)
TRIDOMUS C, Zimmer 621
Ludolf-Krehl-Str. 13 - 17
Neurons of the vertebrate brain are highly polarized of all cells which develop and maintain two distinct types of processes: a single long axon and multiple short dendrites. Axons and dendrites differ fundamentally in their complement of membrane proteins and in their composition of cytoskeletal components.
Neuronal polarity is severely perturbed in certain neurodegenerative diseases, such as Alzheimer’s disease (AD). For example, aberrant sorting of the axonal tau protein into dendrites is a hallmark of early Alzheimer-related pathology. It is thus important to obtain a deeper understanding of the molecular control of neuronal polarity thus providing novel approaches for preventing neuronal degeneration.
In this context, our current research focuses on the role of the ankyrin membrane adapter proteins in the central and peripheral nervous system. Our findings strongly suggest that members of this protein family act as key players for development and maintenance of neuronal polarity.
Structure of the Group
|Group Leader:||Christian Schultz|
|Postdoctoral fellow:||Maren Engelhardt|
|PhD student:||Jürgen. M. Sobotzik|
|Undergraduates:||Annika Gutzmann, Alois Gromann|
|Technicians:||Rebecca Hollender, Silke Vorwald, Anja Uhl|
|Office Manager:||Käthe Neumann|