Mechanisms of neuronal polarity

Schultz Christian Schultz

Medizinische Fakultät Mannheim der Universität Heidelberg
Center for Biomedicine and Medical Technology Mannheim (CBTM)
TRIDOMUS C, Zimmer 621
Ludolf-Krehl-Str. 13 - 17
D-68167 Mannheim

Phone:  +49 621 383 9942
Fax:  +49 621 383 9949

Research Summary

Neurons of the vertebrate brain are highly polarized of all cells which develop and maintain two distinct types of processes: a single long axon and multiple short dendrites. Axons and dendrites differ fundamentally in their complement of membrane proteins and in their composition of cytoskeletal components.

Neuronal polarity is severely perturbed in certain neurodegenerative diseases, such as Alzheimer’s disease (AD). For example, aberrant sorting of the axonal tau protein into dendrites is a hallmark of early Alzheimer-related pathology. It is thus important to obtain a deeper understanding of the molecular control of neuronal polarity thus providing novel approaches for preventing neuronal degeneration.

In this context, our current research focuses on the role of the ankyrin membrane adapter proteins in the central and peripheral nervous system. Our findings strongly suggest that members of this protein family act as key players for development and maintenance of neuronal polarity.

Structure of the Group

Group Leader:  Christian Schultz
Postdoctoral fellow:  Maren Engelhardt
PhD student:  Jürgen. M. Sobotzik
Undergraduates:  Annika Gutzmann, Alois Gromann
Technicians:  Rebecca Hollender, Silke Vorwald, Anja Uhl
Office Manager:  Käthe Neumann


Editor: Email
Latest Revision: 2013-03-06
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