Molecular genetics of signal-dependent gene expression

Schuetz Günther Schütz

Department of Molecular Biology of the Cell I
German Cancer Research Center (DKFZ)
INF 280
69120 Heidelberg

Phone:  +49-6221-423411
Fax:  +49-6221-423470

Research Summary

To understand the role of nuclear receptors, mutations in the mouse including cell-specific and inducible mutations have been generated. This approach allowed to define e.g. a role of the glucocorticoid receptor in control of body weight (Figure 1), of the mineralocorticoid receptor in behavioural plasticity, and established the mechanism of positive feedback of the estradiol receptor in the brain. The orphan receptor tailless is crucial for neurogenesis in the adult and is involved in brain tumor formation (Figure 2).

Structure of the Group

Group Leader:  Günther Schütz
Postdoctoral fellows:  Stefan Berger, Andrii Domanskyi, Gitta Erdmann, Milen Kirilov, Witold Konopka, Grzegorz Kreiner, Hai-Kun Liu, Rosanna Parlato, Jan Rodriguez Parkitna, Caroline Ronzaud, Ying Wang
PhD-Students:  Daniel Habermehl, Claus Rieker
Undergraduates Martin Novak
Technicians:  Tabea Arnsperger, Dagmar Bock, Sebastian Hofelzer, Stefanie Stotz, Andrea Takacs, Magdalena Westphal


Editor: Email
Latest Revision: 2013-03-06
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