Cross talk between excitatory and inhibitory synapses and ion channel & signaling function of NMDA receptors

Koehr Georg Köhr

Dept. Neurophysiology
Mannheim Center for Translational Neuroscience (MCTN)
Medical Faculty Mannheim, Heidelberg University
Ludolf-Krehl-Str. 13-17
68167 Mannheim

Phone:  +49 - 621 - 383 71408
Fax:  +49 - 621 - 383 71401

Research Summary

Sensory experience affects neuronal activity, which modifies the strength or efficacy of synaptic transmission at excitatory and/or inhibitory synapses. Synaptic transmission can be enhanced or depressed lasting from milliseconds to hours or days. Our group studies short-term synaptic plasticity between GABAergic interneurons in the cerebellum involving spillover of transmitter, and long-term synaptic plasticity at two hippocampal synapses involving NMDA receptors. In addition, we are investigating ion channel function and signaling pathways of distinct NMDA receptor subtypes.

Structure of the Group

Group Leader:  Georg Köhr
Postdoctoral fellows:  Simone Astori, Marie Pollard
PhD-Students:  Sven Berberich, Claudia Rauner
MD-Students:  Marina Fendel


Editor: A. Summerfield
Latest Revision: 2020-09-28
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