Search for Bading, H. publications on pubmedlogo


Selection of peer-reviewed publications

Bading, H. and Greenberg, M.E. (1991).
Stimulation of protein tyrosine phosphorylation by NMDA receptor activation.
Science 253, 912-914.

Bading, H., Ginty, D.D., Greenberg, M.E. (1993).
Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways.
Science 260, 181-186.

Ginty, D.D. Kornhauser, J.M., Thompson, M.A., Bading, H., Mayo, K.E., Takahashi, J.S., and Greenberg, M.E. (1993).
Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock.
Science 260, 238-241.

Hardingham, G.E., Chawla, S., Johnson, C.M., Bading, H. (1997).
Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression.
Nature 385, 260-265.

Chawla, S., Hardingham, G.E, Quinn, D.R., Bading, H. (1998).
CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV.
Science 281, 1505-1509.

Cruzalegui, F.H., Hardingham, G.E., and Bading, H. (1999).
c-Jun functions as a calcium-regulated transcriptional activator in the absence of JNK/SAPK1 activation.
EMBO J. 18, 1335-1344.

Hardingham, G.E, Chawla, S., Cruzalegui, F.H., and Bading, H. (1999).
Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels.
Neuron 22, 789-798.

Hardingham, G.E, Arnold, F.J.L., Bading, H. (2001)
Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity.
Nat Neurosci 4, 261-267.

Hardingham, G.E, Arnold, F.J.L., and Bading, H. (2001)
A calcium microdomain near NMDA receptors: on-switch for ERK-dependent synapse-to-nucleus communication.
Nature Neuroscience 4, 565-566.

Hardingham, G.E, Fukunaga, Y., Bading, H. (2002)
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and death pathways.
Nat Neurosci 5, 405-415.

Chawla, S., Vanhoutte, P., Arnold, F.J.L., Huang, C.L.-H., and Bading, H. (2003)
Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5.
J. Neurochem. 85, 151-159.

Zhang, S.-J., Steijaert, M.N., Lau, D., Schütz, G., Delucinge-Vivier, C., Descombes, P., and Bading, H. (2007)
Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death.
Neuron 53, 549-562.

Zhang, S.J., Zou, M., Lu, L., Lau, D., Ditzel, D.A., Delucinge-Vivier, C., Aso, Y., Descombes, P., Bading, H. (2009)
Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity.
PLOS Genet 5: e1000604.

Lau, D., Bading, H. (2009)
Synaptic activity-mediated suppression of p53 and induction of nuclear calcium-regulated neuroprotective genes promote survival through inhibition of mitochondrial permeability transition.
J. Neurosci. 29, 4420-4429.

Wittmann, M., Queisser, G., Eder, A., Wiegert, J.S., Bengtson, C.P., Hellwig, A., Wittum, G., Bading, H. (2009)
Synaptic activity induces dramatic changes in the geometry of the cell nucleus: interplay between nuclear structure, histone H3 phosphorylation and nuclear calcium signaling.
J. Neurosci. 29, 14687-14700.

Bengtson, C.P., Freitag, H.E., Weislogel, J.-M., Bading, H. (2010)
Nuclear calcium sensors reveal that repetition of trains of synaptic stimuli boosts nuclear calcium signaling in CA1 pyramidal neurons.
Biophys. J. 99, 4066-4077.

Zhang, S.J., Buchthal, B., Lau, D., Hayer, S., Dick, O., Schwaninger, M., Veltkamp, R., Zou, M., Weiss, U., Bading, H. (2011)
A signaling cascade of nuclear calcium–CREB-ATF3 activated by synaptic NMDA receptors defines a gene repression module that protects against extrasynaptic NMDA receptor-induced neuronal cell death and ischemic brain damage.
J. Neurosci. 31, 4978-4990.

Mauceri, D., Freitag, H.E., Oliveira, A.M., Bengtson, C.P., Bading, H. (2011)
Nuclear calcium-VEGFD signaling controls maintenance of dendrite arborization necessary for memory formation.
Neuron 71, 117-130.

Oliveira, A.M., Hemstedt, T.J., Bading, H. (2012)
Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities.
Nat Neurosci 15, 1111-1113.

Weislogel, J.-M., Bengtson, C.P., Müller, M.K., Hörtzsch, J.N., Bujard, M., Schuster, C.M., Bading, H. (2013)
Requirement of nuclear calcium signaling in Drosophila long-term memory.
Science Signaling 6, 274, ra33.

Lau, D., Bengtson, C.P., Buchthal, B., Bading, H. (2015)
BDNF reduces toxic extrasynaptic NMDA receptor signaling via synaptic NMDA receptors and nuclear calcium-induced transcription of inhba/Activin A.
Cell Reports 12, 1353-1366.

Oliveira, A.M., Hemstedt, T.J., Freitag, H.E., Bading, H. (2016)
Dnmt3a2: a hub for enhancing cognitive functions.
Molecular Psychiatry 21, 1130-1136.

Monaco, S., Jahraus, B., Samstag, Y., Bading, H. (2016)
Nuclear calcium is required for human T cell activation.
J. Cell Biol. 215, 231-243.

Yu, Y., Oberlaender, K., Bengtson, C.P., Bading, H. (2017)
One nuclear calcium transient induced by a single burst of action potentials represents the minimum signal strength in activity-dependent transcription in hippocampal neurons.
Cell Calcium 65, 14-21.

Hemstedt, T.J., Bengtson, C.P., Ramirez, O., Oliveira, A.M., Bading, H. (2017)
Reciprocal interaction of dendrite geometry and nuclear calcium-VEGFD signaling gates memory consolidation and extinction.
J. Neurosci. 37, 6946-6955.

Pruunsild, P., Bengtson, C.P., Bading, H. (2017)
Networks of cultured iPSC-derived neurons reveal the human synaptic activity-regulated adaptive gene program.
Cell Rep 18, 122-135.

Depp C, Bas-Orth C, Schroeder L, Hellwig A, Bading H. (2018)
Synaptic Activity Protects Neurons Against Calcium-Mediated Oxidation and Contraction of Mitochondria During Excitotoxicity.
Antioxid Redox Signal in press


Selected reviews

Bading, H. (2000)
Transcription-dependent neuronal plasticity: the nuclear calcium hypothesis.
Eur. J. Biochem. 267, 5280-5283.

Hardingham, G.E., Bading, H. (2010)
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders.
Nat Rev Neurosci 11, 682-696.

Bading, H. (2013)
Nuclear Calcium Signaling in the Regulation of Brain Function.
Nat Rev Neurosci 14, 593-608.

Bading, H. (2017)
Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations.
J Exp Med 214, 569-578.

Hardingham, G.E., Pruunsild, P., Greenberg, M.E., Bading, H. (2018)
Lineage divergence of activity-driven transcription and evolution of cognitive ability.
Nat Rev Neurosci 19, 9-15.

Editor: A. Summerfield
Latest Revision: 2018-02-05
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