27.03.2019     13:00

Neurobiology / SFB1134 Lecture

 

Fabian C. Roth
Institute of Basic Medical Sciences, University of Oslo, Norway

Fast action potential signaling in parvalbumin-expressing interneuron axons

 

Parvalbumin-expressing basket cells (PV+-BCs) organize neuronal network dynamics with their ability to generate barrages of fast feedforward and feedback inhibition. Previous studies have revealed a consortium of subcellular signaling mechanisms that convert a single action potential (AP) in the PV+-BC axon initial segment to an inhibitory output from presynaptic terminals with high speed and temporal precision, but how this tight temporal coupling is maintained during high-frequency firing remains unknown.

To address this question, we performed direct patch-clamp recordings from hippocampal PV+-BC dendrites and axons to show that PV+-BCs express HCN channels exclusively in the axon. HCN channels in PV+-BC axons facilitate the initiation and accelerate the propagation of high-frequency APs by opposing the AP-dependent hyperpolarization produced by Na+-K+ ATPases. Furthermore, HCN channels preserve the precise temporal structure of the AP train during its propagation along PV+-BC axons. As axonal AP initiation and propagation is a crucial determinant of the timing of synaptic transmission, the cell type-specific subcellular distribution of HCN channels provides PV+-BCs with a mechanism to operate with high speed and precision.

Related publications:
Hu, H., Roth, F. C., Vandael, D., & Jonas, P. (2018). Neuron, 98(1), 156–165.e6.
Hu, H., & Jonas, P. (2014). Nat Neurosci, 17(5), 686–693.
Hu, H., Gan, J., & Jonas, P. (2014). Science, 345(6196), 1255263–1255263.

 

HS2
Im Neuenheimer Feld 306
Heidelberg

 

03.04.2019     13:00

IZN Seminar

 

Neural dynamics in rat medial prefrontal cortex during extinction learning

Georg Köhr (AG Köhr)

 

Investigating human auditory cortex responses to voice pitch information with near-infrared light

Kurt Steinmetzger (AG Rupp)

 

HS2
Im Neuenheimer Feld 306
Heidelberg

 

10.04.2019     13:00

Neurobiology Lecture

 

New therapeutic approaches to rescue cognitive impairment in Down syndrome

Laura Cancedda
Italian Institute of Technology, Genoa, Italy

 

HS2
Im Neuenheimer Feld 306
Heidelberg

 

14 & 15 July, 2019

IZN Retreat
 
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IZN/Chica and Heinz Schaller Young Investigator Neuroscience Award

Call for Nominations for the 2019 Award

The IZN/Chica and Heinz Schaller Young Investigator Neuroscience Award is an annual prize offered by the Chica and Heinz Schaller Foundation and is given in recognition of an outstanding first-author research publication in any aspect of neuroscience. Candidates must be current members of IZN research groups or have been members while the relevant work was performed. IZN group leaders are excluded unless the work was clearly done during their post-doctoral or PhD period at IZN. Self-nomination of candidates is encouraged.

Deadline for nominations is May 31, 2019 and the award winner will be notified mid-June 2019. The prize money of 1,000€ is to be used at the winner’s or winners’ discretion and may be divided between equally contributing first authors. The prize will be presented at an award ceremony during the annual IZN Retreat, July 14-15, 2019, at Kloster Schöntal, where the successful candidate will make a 10‑minute presentation of his/her work.

Applications should include:

  • CV
  • Scientific justification (one page, single spaced, Arial 11)
  • Summary of the significance of the work in lay terms (half a page, single spaced, Arial 11)
  • Original paper published or accepted for publication in 2018 or before May 31, 2019

Please send your application by email to Prof.Dr. Ricarda Diem (ricarda.diem@med.uni-heidelberg.de) on behalf of the IZN Award Selection Committee.

 


 

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Foundation BrainAid IZN Master’s Award

For the best Master’s Thesis in the Interdisciplinary Center for Neurosciences at Heidelberg University

Call for Nominations for the 2019 Award

The Foundation BrainAid IZN Master’s Award is an annual prize given in recognition of an outstanding Master’s Thesis in the Neurosciences. Candidates must be current members of IZN research groups or have been members while the relevant work was performed. Self-nomination of candidates is encouraged.
Deadline for self-nominations is May 31, 2019. The prize will be awarded during the annual IZN retreat, July 14/15, 2019, at Kloster Schöntal.
Applications should include:

  • CV
  • Scientific justification (one page, single spaced, Arial 11)
  • Summary of the significance of the work in lay terms (half a page, single spaced, Arial 11)
  • PDF file of the Master Thesis completed in 2018 or before May 31, 2019

Please send your application by Email to the Chair of the selection committee, Prof.Dr. Christoph Schuster (Schuster@nbio.uni-heidelberg.de).

 


 

Human blood cells can be directly reprogrammed into neural stem cells

Foto © M.C. Thier/DKFZ

Scientists from the German Cancer Research Center (DKFZ) and the stem cell institute HI-STEM* in Heidelberg have succeeded for the first time in directly reprogramming human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur during the early embryonic development of the central nervous system. They can be modified and multiplied indefinitely in the culture dish and can represent an important basis for the development of regenerative therapies.

Together with stem cell researcher Frank Edenhofer from the University of Innsbruck and neuroscientist Hannah Monyer from DKFZ and the Heidelberg University Hospital, Andreas Trumpp (German Cancer Research Center (DKFZ) and Director of HI-STEM in Heidelberg) and his team have succeeded in reprogramming different human cells: connective tissue cells of the skin or pancreas as well as peripheral blood cells. "The origin of the cells had no influence on the properties of the stem cells," said Marc Christian Thier, first author of the study. In particular, the possibility of extracting neural stem cells from the blood of patients without invasive intervention is a decisive advantage for future therapeutic approaches. More...


Erfolgreiche Forschung zu Multipler Sklerose: 2,7 Millionen Euro für die nächste Förderperiode

DiemBei Multipler Sklerose (MS) greift das Immunsystem körpereigenes Nervengewebe an, Nervenzellen sterben ab. Könnte ein gestörter Kalzium-Haushalt der beteiligten Zellen Ursache und Antrieb der chronischen Erkrankung sein? Dieser zentralen Frage geht die Forschungsgruppe 2289 der Deutschen Forschungsgemeinschaft (DFG) unter Federführung von Professor Dr. Ricarda Diem, Neurologische Universitätsklinik Heidelberg, und Professor Dr. Veit Flockerzi, Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, nach. Beteiligt sind Wissenschaftlerteams aus Heidelberg, Homburg und Hamburg-Eppendorf. Die DFG unterstützt die Forschungsgruppe "Kalzium-Homöostase bei Neuroinflammation und -degeneration" für weitere drei Jahre mit insgesamt 2,7 Millionen Euro. Mehr...


Highly Cited Researchers 2018

Highlycitedresearchers2018


Four IZN Investigators included in the list of world-class researchers selected for their exceptional research performance, demonstrated by production of multiple highly cited papers that rank in the top 1% by citations for field and year in Web of Science.


EMBL researchers discover that four organs in a marine worm’s head can sense different chemicals

Internal anatomy of a marine worm’s head. In blue is seen the individual cell nuclei and all nervous fibres are seen in green. IMAGE: Thomas Chartier and Wiebke Dürichen /EMBL

We sense the world around us using primarily our eyes, ears and nose. Marine worms, on the other hand, have long been thought to understand the world very differently – primarily by detecting chemicals in the ocean water that surrounds them – although this has not been investigated in detail. Now, researchers in the Arendt group have recorded nerve cell activity in the head of marine worms. The worm’s small size and transparency, means that all of the nerves and neurons within the head can be imaged at once. They found that these cells located in four particular areas of the head reacted when the worms were exposed to different chemicals. Alcohols, sugars, amino acids and an ester that smells like pears were tested. Reporting in Open Biology, the group identified these four areas of the head as the worm’s chemosensory organs, capable of detecting different chemicals in the surrounding environment. The worm’s antennae could detect each chemical equally well, whereas three other organs responded to each chemical differently. These chemosensory organs could help the worm go about its daily business of eating, escaping from prey or reproducing. More...


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Open positions at the IZN

  • The group of Prof. Andreas Draguhn is looking for an outstanding PhD student for a pathophysiological study in cellular neurophysiology to study changes in retinal function following experimental autoimmune optic neuritis, with particular emphasis on alterations in synaptic transmission and glutamate homeostasis. Methods include cellular electrophysiology, microscopy, viral transduction and histological/morphological techniques. Adobe
    Posted 02.2019


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Contact

Managing Director:
Prof. Dr. Hilmar Bading
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16500
Fax:  +49 - 6221 - 54 16524
email:  Bading@nbio.uni-heidelberg.de

 

Coordinator:
Dr. Otto Bräunling
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16502, 56 39007
Fax:  +49 - 6221 - 54 16524
email:  Braeunling@nbio.uni-heidelberg.de

 

Administration & Information:
Irmela Meng
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16501
Fax:  +49 - 6221 - 54 16524
email:  Sekretariat@nbio.uni-heidelberg.de
Webmaster contact: WebmasterIZN@uni-heidelberg.de
Latest Revision: 2019-03-22
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