07.12.2022 13:00


Norepinephrine induces activity-dependant Ca2+ transients in oligodendrocyte progenitor cells and regulates their fate

Frédéric Fiore (AG Agarwal)


Investigating the development and role of Unipolar Brush Cells during mouse cerebellar development

Lisa Spänig (AG Kutscher)


SR 14, INF306

ZOOM Meeting ID 880 7727 5856 Passcode 444344

Merry Christmas!



IZN Concepts Talk

1.2.2023 13:00



Prof.Dr. Claudio Joazeiro

Center for Molecular Biology (ZMBH)
Universität Heidelberg



SR 13, INF306

ZOOM Meeting ID 880 7727 5856 Passcode 444344


Welcome to the IZN Home Page

Selected cells
Kuner T Fig1
Pauen Fig1
Poggi Figure2
Rappold Fig1
Holstein Fig1


How does our brain integrate space geometry and territory?

Neural basis to process space geometry

A team of researchers aims to understand the neural basis of people's ability to process space geometry along the sense ofGrinevich Valery space ownership, utilities and social hierarchies, leading to the perception of territoriality. The team coordinated by Prof. Dr. Valery Grinevich (Central Institute of Mental Health/Germany) is composed by his group and the labs led by Angela Sirigu (Centre National de la Recherche Scientifique CNRS/France), Dori Derdikman (Technion – Israel Institute of Technology/Israel), and David Omer (The Hebrew University of Jerusalem/Israel). Their common research project has now received major grants from the European Research Council (ERC), namely synergy ERC grant (10 Mio Euros for 6 years), to address this challenging multidisciplinary research problem.

ZI press release Externer Inhalt

ERC press release Externer Inhalt

Second Stem Cell Type Discovered in Mouse Brain

Heidelberg neurobiologists gain new insights into formation of nerve cells

ciccolini.jpgIn the brain of adult mammals neural stem cells ensure that new nerve cells, i.e. neurons, are constantly formed. This process, known as adult neurogenesis, helps mice maintain their sense of smell. A research team led by Dr Francesca Ciccolini at the Interdisciplinary Center for Neurosciences (IZN) of Heidelberg University recently discovered a second stem cell population in the mouse brain. This new type of stem cell, and not the one previously known, is primarily involved in the production of new neurons in the olfactory bulb of adult mice.

“Our discovery that another stem cell type exists in the mouse brain of adult animals throws new light on the processes of neuron formation” emphasises Dr Ciccolini. The human brain has similar stem cells that are involved in the formation of brain tumours. The Heidelberg researchers hope that their work will also shed new light on the development and possible treatment of such tumours. Press release Externer Inhalt

Heidelberg researchers identify molecular mechanisms that influence pain processing and sensitivity

One epigenetic factor as well as one organic aniMauceripicon transporter (OAT1), whose function in the nervous system was hitherto unknown, contribute to the development of chronic pain. The underlying molecular mechanism was identified by a team of researchers led by Dr Daniela Mauceri at the Interdisciplinary Center for Neurosciences (IZN) of Heidelberg University. Using mouse models, the researchers demonstrated that the epigenetic factor, known as HDAC4, influences the expression of genes in neuronal cells involved in the processing of pain. The Heidelberg experiments also revealed that the transporter OAT1 regulates pain sensitivity in the spinal cord. The team hopes their findings will pave the way to new approaches for the treatment of chronic pain.

The research work was conducted under the auspices of Heidelberg University’s Collaborative Research Centre 1158, 'From nociception to chronic pain: Structure-function properties of neural pathways and their reorganization', whose spokesperson is Prof. Kuner. The results of the study were published in the journal 'Nature Communications'. More....Externer Inhalt


Open positions at the IZN

  • Prof. Jan Siemens' lab is looking for a motivated Doctoral Student with an interest in studying neuronal pathways and cell-molecular mechanisms of pain sensation. Experimental work will include using the mouse as a model system combined with multidisciplinary ex-vivo and in vivo approaches, such as metabolic analysis / metabolic flux measurements, genetic mouse models, behavior experiments and testing of experimental analgesic drug candidates targeting a metabolic signaling pathway. Adobe
    Posted 11.2022

  • The Department of Neurobiology is offering a doctoral student scholarship. Topic: Primary cilia in neural stem cells Adobe
    Posted 11.2022

  • The Department of Neurobiology is seeking to hire a laboratory technician (50%). The ideal candidate will have some cell culture experience and be familiar with the procedures for preparation of primary hippocampal and cortical cultures. Adobe
    Posted 11.2022

  • A postdoc position is currently available in the research group of Dr. Ana Oliveira (Neurobiology, Heidelberg and CIMH, Mannheim). The ideal candidate will be investigating the molecular mechanisms of memory persistence using state-of-the-art methodology (engram tagging tools, chemogenetics, omics approaches and behavioral testing). Adobe
    Posted 07.2022

  • A postdoc / scientific assistant position is offered in the Kann Group at the Institute of Physiology and Pathophysiology. The group deals with neuronal activity patterns, such as gamma oscillations, which are related to perception, attention and memory. There is special interest in the two research focuses (i) neuronal energy metabolism and (ii) neuroinflammation. The group is interdisciplinary and offers an intensive scientific atmosphere with a broad spectrum of established methods (electrophysiology, fluorescence imaging, oxymetry, ELISA, brain slice preparations etc.). Adobe
    Posted 06.2022




IZN Managing Director:
Prof. Dr. Hilmar Bading
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16500
Fax:  +49 - 6221 - 54 16524


IZN Administration & Information:
Antje König
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16501
Fax:  +49 - 6221 - 54 16524


IZN Coordinator:
Dr. Anna Hertle
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16502
Fax:  +49 - 6221 - 54 16524


IZN PhD Programme Coordinators:
Irmela Meng, Prof. Christoph Schuster
IZN Graduate School, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16503
Fax:  +49 - 6221 - 54 16524


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Latest Revision: 2022-11-30
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