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News...

The 2022 Retreat Gallery is now available for you to upload your photos from the event


Dr. Otto Bräunling announced as Honorary Member of the IZN

 
Otto Bräunling
1987 Diploma Thesis, German Cancer Research Center
1987-1990 PhD Thesis, EMBL and DENAGEN, Heidelberg
1991-2002 Postdoctoral fellow, Neurobiology, University of Heidelberg
1998-2000 Freelancer, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
2000-2022 IZN Coordinator
2002 Akademischer Rat
2004-2022 Coordinator of the IZN PhD Programme
2006-2022 Akademischer Oberrat
2020 Award: Best Lab Manager, Proteintech

Heidelberg researchers identify molecular mechanisms that influence pain processing and sensitivity

One epigenetic factor as well as one organic aniMauceripicon transporter (OAT1), whose function in the nervous system was hitherto unknown, contribute to the development of chronic pain. The underlying molecular mechanism was identified by a team of researchers led by Dr Daniela Mauceri at the Interdisciplinary Center for Neurosciences (IZN) of Heidelberg University. Using mouse models, the researchers demonstrated that the epigenetic factor, known as HDAC4, influences the expression of genes in neuronal cells involved in the processing of pain. The Heidelberg experiments also revealed that the transporter OAT1 regulates pain sensitivity in the spinal cord. The team hopes their findings will pave the way to new approaches for the treatment of chronic pain.

The research work was conducted under the auspices of Heidelberg University’s Collaborative Research Centre 1158, 'From nociception to chronic pain: Structure-function properties of neural pathways and their reorganization', whose spokesperson is Prof. Kuner. The results of the study were published in the journal 'Nature Communications'. More....Externer Inhalt


Molecular Switch for Addiction Behaviour

Newly discovered mechanism determines how strongly mice respond to cocaine

A molecular switch influences addiction behaviour and determines how strong the response toBading2 addictive drugs is. A research team at Heidelberg University and the Sorbonne University in Paris (France) made the discovery in mice treated with cocaine. The researchers led by Prof. Dr. Hilmar Bading (Heidelberg) and Prof. Dr Peter Vanhoutte (Paris) demonstrated that the protein Npas4 regulates the structure and function of nerve cells that control addiction behaviour in mice. If the quantity of Npas4 was reduced in an experiment, the animals’ response to cocaine was much weaker. More... Externer Inhalt


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Open positions at the IZN

  • Two HiWi positions are available in the group of Prof. Hilmar Bading. The successful candidates will use techniques related but not limited to primary neuronal cell culture, human iPSC- derived neurons culture, calcium imaging, gene cloning, rAAV production, Western blotting, qRT-PCR, cryosectioning, IHC, and mouse behavior-related work. The applicants should hold Bachelors' or Masters' degrees in biosciences or a related field. Adobe
    Posted 07.2022

  • A postdoc position is currently available in the research group of Dr. Ana Oliveira (Neurobiology, Heidelberg and CIMH, Mannheim). The ideal candidate will be investigating the molecular mechanisms of memory persistence using state-of-the-art methodology (engram tagging tools, chemogenetics, omics approaches and behavioral testing). Adobe
    Posted 07.2022

  • The group of Dr. Daniela Mauceri (Neurobiology, IZN) is offering a HiWi position involving neuronal cell culture, rAAV production, Western blotting, immunocytochemistry, qRT-PCR, subcloning, fluorescent microscopy (confocal, widefield), cryosectioning. Adobe
    Posted 07.2022

  • A postdoc / scientific assistant position is offered in the Kann Group at the Institute of Physiology and Pathophysiology. The group deals with neuronal activity patterns, such as gamma oscillations, which are related to perception, attention and memory. There is special interest in the two research focuses (i) neuronal energy metabolism and (ii) neuroinflammation. The group is interdisciplinary and offers an intensive scientific atmosphere with a broad spectrum of established methods (electrophysiology, fluorescence imaging, oxymetry, ELISA, brain slice preparations etc.). Adobe
    Posted 06.2022

  • Das Institut für Anatomie und Zellbiologie (Abteilung Medizinische Zellbiologie - Prof. Joachim Kirsch) sucht einen Postdoc (m/w/d) zur Mitarbeit in einem europäischen Projekt zur Entwicklung eines innovativen Aus- und Weiterbildungskonzeptes für Humanmediziner. In diesem Pilotprojekt kommen multimediale Techniken zum Einsatz und kombinieren textuelle Inhalte mit anschaulichen Grafiken, Animationen und 3D-Druck. https://karriere.klinikum.uni-heidelberg.de/index.php?ac=jobad&id=15485
    Posted 05.2022

  • Are you interested in the human brain and associated disorders? Do you want to use state-of-the-art in vitro and bioinformatic tools to tackle human diseases? The Hector Institute for Translational Brain Research (HITBR) has 2 vacant positions: postdoctoral fellow and PhD student in translational stem cell research in psychiatry. Adobe
    Posted 05.2022

  • The Hector Institute for Translational Brain Research (HITBR) at the Central Institute of Mental Health (ZI) in Mannheim s looking for a highly motivated master student for an internship and/or master project.. The ideal candidate will have some cell culture experience and a great interest in neurodevelopment and the molecular understanding of pathological pathways underlying transformation of CNS cells into malignant tumor entities. Adobe
    Posted 04.2022

  • A PhD position is available at the Hector Institute for Translational Brain Research (HITBR) at the Central Institute of Mental Health (ZI) in Mannheim. The ideal candidate will have a strong interest in neurobiology, psychiatry, stem cell research, biotechnology and disease modeling. Adobe
    Posted 04.2022


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Contact

 

IZN Managing Director:
Prof. Dr. Hilmar Bading
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16500
Fax:  +49 - 6221 - 54 16524
email:  Bading@nbio.uni-heidelberg.de

 

IZN Administration & Information:
Antje König
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16501
Fax:  +49 - 6221 - 54 16524
email:  Sekretariat@nbio.uni-heidelberg.de

 

IZN Coordinator:
Dr. Anna Hertle
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16502
Fax:  +49 - 6221 - 54 16524
email:  IZN.Coordinator@uni-heidelberg.de

 

IZN PhD Programme Coordinators:
Irmela Meng, Prof. Christoph Schuster
IZN Graduate School, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16503
Fax:  +49 - 6221 - 54 16524
email:  IZN-GradSchool@uni-heidelberg.de

 

Webmaster contact: WebmasterIZN@uni-heidelberg.de
Latest Revision: 2022-07-29
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