14.06.2023 13.00

IZN Seminar

 

Morphological and mitochondrial changes in murine choroid plexus epithelial cells during healthy aging

Valentina Scarpetta (AG Patrizi)

 

SR25, INF328

Hybrid ZOOM meeting ID 880 7727 5856 Passcode 444344

 
28.06.2023 13.00

IZN Seminar

 

Path integration in grid cell networks during a homing task

Jingjie Peng (AG Allen)

 

SR25, INF328

Hybrid ZOOM meeting ID 880 7727 5856 Passcode 444344

 
05.07.2023 13.00

IZN Concepts Talk

 

Prof. Claudio Joazeiro

Center for Molecular Biology (ZMBH)
Universität Heidelberg

 

SR25, INF328

Hybrid ZOOM meeting ID 880 7727 5856 Passcode 444344

 
19.07.2023 13.00

Neurobiology Lecture

 

Dr. Simona Lodato

HUNIMED,

Milan, Italy

 

SR25, INF328

Hybrid ZOOM meeting ID 880 7727 5856 Passcode 444344

 
26.07.2023 13.00

IZN Seminar

 

APPsa rescues CDK5 and GSK3b dysregulation and restores normal spine density in Tau transgenic mice

Danny Baltissen (AG Müller)

 

SR25, INF328

Hybrid ZOOM meeting ID 880 7727 5856 Passcode 444344

 

 

Welcome to the IZN Home Page

Selected cells
 
Kuner T Fig1
 
Pauen Fig1
 
Poggi Figure2
 
Rappold Fig1
 
Holstein Fig1

News...

2023 IZN Competition and Awards:

IZN Art Competition

IZN/Chica and Heinz Schaller Young Investigator Neuroscience Award

Foundation BrainAid IZN Master’s Award

Foundation BrainAid IZN Dissertation Award

 

Full details here Externer Inhalt


Dietmar Hopp Stiftung fördert Erforschung eines neuen Therapiekonzepts bei wiederkehrenden Hirntumoren mit 1,8 Millionen Euro

Neurochirurgische Universitätsklinik Heidelberg startet Projekt zu Kombinationstherapie bei nachgewachsenem Glioblastom: Können die zielgenaue Erhitzung über eine Lasersonde und Medikamententests an Minitumoren dazu beitragen, weiteres Tumorwachstum zu verlangsamen?

Glioblastome sind höchst aggressiHerold Mendeve Hirntumoren, die trotz intensiver Therapie nach wenigen Monaten nachwachsen. Um die Überlebenszeit von Patienten mit einem solchen Rezidiv zu verlängern, prüfen Medizinerinnen, Mediziner und Forschende der Neurochirurgischen Klinik am Universitätsklinikum Heidelberg (UKHD) nun im Rahmen einer klinischen Studie ein neuartiges Therapiekonzept: Der Erhitzung des Tumors mittels einer minimal-invasiv eingebrachten Lasersonde folgen personalisierte Medikamententests an Miniversionen des Patiententumors. An diesen sogenannten Tumororganoiden können mehrere Medikamente gleichzeitig getestet und die wirksamsten identifiziert werden. Das Team um die Projektleiter Privatdozent Dr. Martin Jakobs und Professorin Dr. Christel Herold-Mende entwickelte dazu eigens ein Verfahren, um die Minitumoren aus den geringen Gewebemengen, die im Rahmen der Laserbehandlung entnommen werden, herzustellen. Die Dietmar Hopp Stiftung fördert die nun gestartete Behandlungsstudie, in die bis zu 30 Patientinnen und Patienten eingeschlossen werden sollen, sowie die Medikamententests an den patientenindividuellen Tumororganoiden vier Jahre lang mit insgesamt 1,8 Millionen Euro. Mehr... Externer Inhalt


Spotlight: Using light and sound to see into the brain

Researchers in the Prevedel Group use this spectroscopy setup to test and optimise photoacoustic probes before their usage in mouse neuroscience.

Photoacoustic spectroscopy provides information about the photoacoustic efficiency of probes, which is a measure of how strongly they generate a photoacoustic signal in the presence of calcium. The custom setup built by the Prevedel Lab measures the photoacoustic signal of specially developed calcium-sensitive molecules in order to steer their development, which is performed by the Deo group at EMBL. These molecules can be used to visualise brain activity with photoacoustic imaging, which allows the scientists to go much deeper into a brain region than other light-based neuroimaging methods. More... Externer Inhalt


Drug alleviates autism-associated behavior in mice

The behavioral disorders observed in autism are associated with a multitude of genetic alterations. Scientists from the Hector Institute for Translational Brain Research (HITBR)* have now found another molecular cause for this condition. The transcription factor MYT1L normally protects the molecular identity of nerve cells. If it is genetically switched off in human nerve cells or in mice, the functional changes and symptoms typical of autism occur. A drug that blocks sodium channels in the cell membrane can reverse the consequences of MYT1L failure and alleviate the functional and behavioral abnormalities in mice.

Moritz Mall from the Hector Institute for Translational Brain Research (HITBR) has long been researching the role of the protein MYT1L in various neuronal diseases. The protein is a so-called transcription factor that decides which genes are active in the cell and which are not. Almost all nerve cells in the body produce MYT1L throughout their entire life span.

Mall had already shown a few years ago that MYT1L protects the identity of nerve cells by suppressing other developmental pathways that programme a cell towards muscle or connective tissue, for example. Mutations in MYT1L have been found in several neurological diseases, such as schizophrenia and epilepsy, but also in brain malformations. In their current work, which is funded by the European Research Council ERC, Mall and his team examined the exact role of the "guardian of neuronal identity" in the development of an ASD. To do this, they genetically switched off MYT1L - both in mice and in human nerve cells that had been derived from reprogrammed stem cells in the laboratory. More... Externer Inhalt


News archive Externer Inhalt


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Open positions at the IZN

  • The Department for Molecular and Cellular Cognition Research (Dr. Ana Oliveira) at the Central Institute of Mental Health (Mannheim, Germany) offers a PhD student position in molecular mechanisms of learning and memory. Adobe
    Posted 02.2023

  • The Department for Molecular and Cellular Cognition Research (Dr. Ana Oliveira) at the Central Institute of Mental Health (Mannheim, Germany) offers a Postdoctoral position in molecular mechanisms of learning and memory. Adobe
    Posted 02.2023

  • Prof. Jan Siemens' lab is looking for a motivated Doctoral Student with an interest in studying neuronal pathways and cell-molecular mechanisms of pain sensation. Experimental work will include using the mouse as a model system combined with multidisciplinary ex-vivo and in vivo approaches, such as metabolic analysis / metabolic flux measurements, genetic mouse models, behavior experiments and testing of experimental analgesic drug candidates targeting a metabolic signaling pathway. Adobe
    Posted 11.2022


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Contact

 

IZN Managing Director:
Prof. Dr. Hilmar Bading
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16500
Fax:  +49 - 6221 - 54 16524
email:  Bading@nbio.uni-heidelberg.de

 

IZN Administration & Information:
Antje König
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16501
Fax:  +49 - 6221 - 54 16524
email:  Sekretariat@nbio.uni-heidelberg.de

 

IZN Coordinator:
Dr. Anna Hertle
IZN-Neurobiology, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Phone:  +49 - 6221 - 54 16502
Fax:  +49 - 6221 - 54 16524
email:  IZN.Coordinator@uni-heidelberg.de

 

IZN PhD Programme Coordinator:
Prof. Christoph Schuster
IZN Graduate School, University of Heidelberg
Im Neuenheimer Feld 366, 1.OG
D-69120 Heidelberg, Germany

Office hours: Tuesday, 11:00–16:00

Phone:  +49 - 6221 - 54 16503
Fax:  +49 - 6221 - 54 16524
email:  IZN-GradSchool@uni-heidelberg.de

 

 

Webmaster contact: WebmasterIZN@uni-heidelberg.de
Latest Revision: 2023-05-31
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