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Faculty of Biosciences > Institute of Pharmacy and Molecular Biotechnology > IPMB, Department Biology 
Publikationen Prof. Dr. M. Wink 
Plant Secondary metabolism, cell cultures, biotechnology

Babaoglu, M., Davey, M. R., Power, J. B., Sporer, F., Wink, M. Transformed roots of Lupinus mutabilis: Induction, culture and isoflavone biosynthesis. Plant Cell Tissue and Organ culture 78, 29-36, 2004

Brown, A., Robins, D., Witte, L. & Wink, M. Stereochemistry of enzymic reactions involved in the formation of tetrahydroanabasine, ammodendrine, smipine and tripiperideine. Life Science Advances 10: 179-185, 1992

Flaig, R., Rosenkranz, V., Wink, M., Fricker, G. Ktenate nanoparticles (bdellosomes): A novel strategy for targetting drugs to parasites, tumours or tissues. Journal of Drug delivery Science and Technology 15, 59-63, 2005

Hanke, M., Wink, M. Direct DNA sequencing of PCR amplified vector inserts following enzymatic degradation of primer and dNTPs. BioTechniques 17, 858-860, 1994

Hartmann, T, Schoofs, G. & Wink, M. A chloroplast-localized lysine decarboxylase of Lupinus polyphyllus. The first enzyme in the biosynthetic pathway of quinolizidine alkaloids. FEBS letters 115, 35-38, 1980

Hauser, M.-T., Wink, M. Uptake of alkaloids by latex vesicles and isolated mesophyll vacuoles of Chelidonium majus (Papaveraceae). Z. Naturforschung; Journal of Bioscince 45c, 949-957, 1990

Lopez-Herraez, D., Schäfer, H., Mosner, J., Fries, R., Wink, M. Comparison of the exclusion power between microsatellite and single nucleotide polymorphism (SNP) markers in individual identification and parental analysis in a Galloway cattle population. Z. Naturforschung; Journal of Bioscience. 60c, 637-643, 2005

Maercker, D., R. Perrey, M. Schneider & Wink, M.: Genexpression in Lupinenzellkulturen. In: "Lupinen 1991- Forschung, Anbau und Verwertung", (M. Wink, ed.), 166-174, 1992

Margl, L., Tei, A. , Gyurjan, I., Wink, M.: GLC and GLC-MS Analysis of Thiophene Derivatives in Plants and in in vitro Cultures of Tagetes patula L. (Asteraceae). Z. Naturforschung; Journal of Bioscience 57, 63-71, 2002

Mende, P. & Wink, M. Uptake of the quinolizidine alkaloid lupanine by protoplasts and isolated vacuoles of suspension-cultured Lupinus polyphyllus Cells. Diffusion or carrier-mediated transport? Journal Plant Physiology 129, 229-242, 1987

Perrey, R. M. Schneider, Wink, M. Tissue-specific expression of a cDNA clone from cell suspension cultures of Lupinus polyphyllus. Plant Molecular Biology 14,1055-1056, 1990

Perrey, R., Wink, M. Constitutive expression and molecular characterization of a cDNA clone encoding a partial HSP70 gene in cell suspension cultures of Lupinus polyphyllus. Journal Plant Physiology 137, 744-748, 1991

Perrey, R., Hauser, M.-T., Wink, M.: Cellular and subcellular localization of peroxidase isoenzymes in plants and cell suspension cultures from Lupinus polyphyllus Z. Naturforschung; Journal of Bioscince 44 c, 931-936,1989

Perrey, R., Warskulat, , U., Wink, M. Molecular cloning of a cDNA for the ubiquitin gene of Lupinus polyphyllus. Nucleic Acids Research 18, 6428, 1990

Perrey, R., Warskulat, U., Wink, M. Molecular cloning of a lupin-specific gene from a cDNA library of suspension-cultured cells of Lupinus polyphyllus. Plant Molecular Biology 15, 175-176,1990

Perrey, R., Warskulat, U., Wink, M. Molecular cloning of a Lupinus polyphyllus cDNA Encoding a basic peroxidase isoenzyme of cell suspension cultures. Journal Plant Physiology 137, 537-540, 1991

Perrey, R., Wink, M. On the role of piperideine and tripiperideine in the biosynthesis of quinolizidine alkaloids. Z.Naturforschung; Journal of Bioscince 43c, 363-369, 1988

Reichling, J., Sauerwein, M., Wink, M. Naphthochinonproduktion in invitro Kulturen von Drosera communis St.Hil. Drogenreport 8, 26-27, 1995

Roberts, M. F. & Wink, M. (eds)., Alkaloids: Biochemistry, ecology and medicinal applications; Plenum, New York, 486 pp, 1998

Sauerwein, M., Schmidt, S., Reichling, J., Wink, M. Naphthoquinone production in invitro cultures of Drosera communis. St.Hil. Bioforum Extra, 26-27, 1994

Sauerwein, M., Shimomura, K. & Wink, M. Incorporation of 13C-acetate into tropane alkaloids by hairy root cultures of Hyoscyamus albus. Phytochemistry 32, 905-909, 1993

Sauerwein, M., Shimomura, K., Wink, M. Alkaloid formation in hairy roots of Hyoscyamus albus. Bioforum 17, 462-463, 1994

Sauerwein, M., Wink, M., Shimomura, K. Influence of light and phytohormones on alkaloid production in transformed root cultures of Hyoscyamus albus. Journal Plant Physiology 140, 147-152

Schabacker, J., Schwend, T., Wink, M. Reduction of acrylamide uptake by dietary proteins in a CaCo-2 gut model. J. Agricultural Food Chemistry 52, 4021-4025, 2004

Schoofs, G., Teichmann, S., Hartmann, T. & Wink, M. Distribution of lysine decarboxylase in higher plants and its integration in the pathway of quinolizidine alkaloid biosynthesis. Phytochemistry 22, 65-69, 1983

Schwend, T., Schabacker, J., Wetterauer, B., Wink, M. Active uptake of S-propionamide-cysteine by Caco-2 cells Z. Naturforschung (accepted)

Schwend, T. Redwanz, I., Ruppert, T., Szenthe, A., Wink, M. Analysis of proteins in the spent culture medium of Lupinus albus by electrospray ionisation tandem mass spectrometry. J. Chromatography A 1009, 105-110, 2003

Sesterhenn, K., Distl, M. Wink, M. Occurrence of iridoid glycosides in invitro cultures and intact plants of Scrophularia nodosa L. Plant Cell Reports 26, 365-371, 2007

Szenthe, A., Schäfer, H., Hauf, J., Schwend, T. & Wink, M. Characterisation and expression of monosaccharide transporters (LpSTP1 and LaSTP1) in lupins. Journal of Plant Research 120, 697-705, 2007

Warskulat, U., Perrey, R., Wink, M. Molecular cloning of a cDNA from Lupinus polyphyllus cell cultures encoding a ribosomal protein (rps 16). Plant Molecular Biology 16, 739-740,1991

Wildi, E. & Wink, M. (eds.). Trends in Medicinal Plant Research; Screening, biotechnology and rational phytotherapy, Romneya-Verlag, Dossenheim, 2001

Wildi, E., Wink, M. Biotechnology potential of hairy root culture. In "Series Recent Progress in Medicinal plants", Vol. 4.-Biotechnology and Genetic Engineering (Eds. J.N. Govil, P. Ananda Kumar & V.K. Singh). Sci Tech Pub., USA, pp 441-454, 2002

Wink, M. & Witte, L. Turnover and transport of quinolizidine alkaloids: Diurnal variation of lupanine in the phloem sap, leaves and fruits of Lupinus albus L. Planta 161, 519-524,1984

Wink, M. & Witte, L. Cell-free synthesis of the alkaloids ammodendrine and smipine. Z.Naturforschung; Journal of Bioscince 42c, 197-204,1987

Wink, M. & Hartmann, T. Activation of chloroplast-localized enzymes of quinolizidine alkaloid biosynthesis by reduced thioredoxin. Plant Cell Reports 1, 6-9, 1981

Wink, M. & Hartmann, T. Diurnal fluctuations of quinolizidine alkaloid accumulation in legumes and cell suspension cultures. Z. Naturforschung; Journal of Bioscince 37c, 369-375, 1982

Wink, M. & Hartmann, T. Enzymatic synthesis of alkaloid esters: A tigloyl-CoA: 13-hydroxylupanine O-tigloyl transferase from Lupinus albus. Planta 156, 560-565, 1982

Wink, M. & Hartmann, T. Localization of the enzymes of quinolizidine alkaloid biosynthesis in leaf chloroplasts of Lupinus polyphyllus. Plant Physiology 70, 74-77 ,1982

Wink, M. & Hartmann, T. Physiological and biochemical aspects of quinolizidine alkaloid formation in cell suspension cultures. Plant Tissue Culture 1982 (Ed. A. Fujiwara) p. 333-334, IAPTC, Tokyo, 1982

Wink, M. & Hartmann, T. Production of quinolizidine alkaloids by photomixotrophic cell suspension cultures: Biochemical and biogenetic aspects. Planta Medica 40, 149-155, 1980

Wink, M. & Hartmann, T. Sites of enzymatic synthesis of quinolizidine alkaloids and their accumulation in Lupinus polyphyllus. Journal of Plant Physiology 102, 337-344, 1981

Wink, M. & Hartmann, T. Cadaverine-pyruvate transamination: the pricipal step of enzymatic quinolizidine alkaloid biosynthesis in Lupinus polyphyllus cell suspension cultures. FEBS letters 101, 343-346, 1979

Wink, M. Production of quinolizidine alkaloids in in vitro cultures of legumes. Biotechnology in Agriculture and Forestry, (edited by Toshiyuki Nagata & Y.Ebizuka ) Springer-Verlag, Vol. 51, 118-136, 2002

Wink, M., Heinen, H. J., Vogt, H. & Schiebe, H. M. I. Cellular localization of quinolizidine alkaloids by laser desorption mass spectrometry. Plant Cell Reports 3, 230-233 ,1984

Wink, M., Hartmann, T., Witte, L. & Schiebel, H. M. The alkaloid pattern of cell suspension cultures and differentiated plants of Baptisia australis and their biogenetic implications. Journal of Natural Products 44, 14-20, 1981

Wink, M., Hartmann, T. & Schiebel, H. M. A model mechanism for the enzymatic synthesis of lupin alkaloids. Z. Naturforschung; Journal of Bioscince 34c, 704-708, 1979

Wink, M., Hartmann, T. & Witte, L. Enzymatic synthesis of quinolizidine alkaloids in lupin alkaloids. Z. Naturforschung; Journal of Bioscince 35c, 93-97, 1980

Wink, M. Biochemistry and chemical ecology of lupin alkaloids. Proc. 3rd Int. Lupin Cong. p 324-343, 1984

Wink, M. Chemical defense of Leguminosae: Are quinolizidine alkaloids part of the antimicrobial defense system of lupins? Z.Naturforschung; c

Wink, M. Chemical defense of lupins: Mollusc-repellent properties of quinolizidine alkaloids. Z. Naturforschung; Journal of Bioscince 39c, 553-558, 1984

Wink, M. Chemische Verteidigung der Lupinen: Zur biologischen Bedeutung der Chinolizidinalkaloide. Plant Syst. Evolution 150, 65-81, 1985

Wink, M. Inhibition of seed germination by quinolizidine alkaloids. Aspects of allopathy in Lupinus albus L. Planta 158, 365-368,1983

Wink, M. Quinolizidine alkaloids:Biochemistry, metabolism, and function in plants and cell suspension cultures. Planta Medica 53, 509-514, 1987

Wink, M. Site of lupanine and sparteine biosynthesis in intact plants and in vitro organ cultures. Z.Naturforschung; Journal of Bioscince 42c, 868-872,1987

Wink, M. The Role of quinolizidine alkaloids in plant insect interactions. In Insect- plant interactions (E. A. Bernays, eds), Vol. IV, 133-169, CRC-Press, Boca Raton, 1992

Wink, M. Wounding-induced increase of quinolizidine alkaloid accumulation in lupin leaves. Z.Naturforschung; Journal of Bioscince 38c, 905-909, 1983

Wink, M. Importance of the polymerase chain reaction (PCR) for plant science. Bioforum Extra, 5-11, 1994

Wink, M. & Witte, L. Alkaloids in stem roots of Nicotiana tabacum and Spartium junceum transformed by Agrobacterium rhizogenes. Z. Naturforschung; Journal of Bioscince 42c, 69-72, 1987

Wink, Hartmann, M. & T. Enzymology of quinolizidine alkaloid biosynthesis.In: Natural products chemistry 1984 (Eds: R. I. Zalewski & J.J. Skolik), Elsevier, Amsterdam, pp 511-520, 1985

Wink, M. & Waterman, P. Chemotaxonomy in relation to molecular phylogeny of plants. In "Biochemistry of plant secondary metabolism" M. Wink, ed., Sheffield Academic Press and CRC Press , Annual Plant Reviews Vol. 2, pp 300-341, 1999

Wink, M. A short history of alkaloids. In "Alkaloids: Biochemistry, ecology and medicinal applications; Roberts, M.F. & Wink, M. eds, pp 11-44, Plenum, New York,1998

Wink, M. (Hrgb): Biochemistry of plant secondary metabolism, Sheffield Academic Press and CRC Press, Annual Plant Reviews Vol. 2, 358 pp, 1999

Wink, M. (Hrgb.): Function of plant secondary metabolites and their exploitation in biotechnology. Sheffield Academic Press and CRC Press, Annual Plant Reviews, Vol. 3, 362 pp, 1999

Wink, M. Allelochemical properties and the raison d'etre of alkaloids. In "The Alkaloids, G. Cordell, ed.), Academic press, Vol. 43, 1-118,1993

Wink, M. An Introduction to Molecular Biotechnology.-Molecular fundamentals, methods and applications in modern biotechnology. Wiley-VCH, 768 Seiten, 2006

Wink, M. and Roberts, M.Compartmentation of alkaloid synthesis, transport and storage. In "Alkaloids: Biochemistry, ecology and medicinal applications; M.F. Roberts, & M. Wink, eds, pp. 239-262, Plenum, New York, 1998

Wink, M. Bioprospecting: The search for bioactive lead structures from Nature. In O.Kayser & W. Quax; Medical Plant Biotechnology. From basic research to industrial applications. Wiley-VCH. Vol. 1 Pp 97-116, 2007

Wink, M. Compartmentation of secondary metabolites and xenobiotics in plant vacuoles. Adv. Bot. Res. 25, 141-169, 1997

Wink, M. Evolution of plant secondary metabolism. Encyclopedia of Life Sciences (in press)

Wink, M. Importance of plant secondary metabolites for protection against insects and microbial infections. In Naturally occurring bioactive compounds: A new and safe alternative for control of pests and diseases, C. Carpinella, M. Rai (eds), 251-268, 2007

Wink, M. Molekulare Biotechnologie.-Konzepte und Methoden. Wiley-VCH, 834 Seiten; 2004

Wink, M. PCR in der Evolutionsforschung In: (M. Wink, H. Wehrle, Hrgb), PCR im medizinischen und biologischen Labor. GIT-Verlag, Darmstadt pp 166-184, 1994

Wink, M. Plant Secondary Metabolism: Diversity, Function and its Evolution. Natural Products Communications (in press)

Wink, M. The cell culture medium- A functional extracellular compartment of suspension cultured cells. Plant Cell and Organ Culture 38, 307-319,1994

Wink, M. The plant vacuole: A multifunctional compartment. J. Exp. Botany vol 44, Supplement 231-246, 1993

Wink, M. Trypanosoma theileri: In vitro cultivation in tsetse fly and vertebrate cell culture systems.International Journal Parasitology 9, 585-589,1979

Wink, M. & Witte, L. Quinolizidine alkaloids as nitrogen source for lupin seedlings and cell suspension cultures.Z. Naturforschung; Journal of Bioscince 40c, 767-775,1985

Wink, M., Alfermann, A.W., Franke, R., Wetterauer, B., Distl, M., Windhövel, J., Krohn, O., Fuss, E., Garden, H., Mohagheghzadeh, A., Wildi, E. & Ripplinger, P. Sustainable bioproduction of phytochemicals by plant in vitro cultures: anticancer agents. In Plant Genetic Resources 3: 90-100, 2005

Wink, M., Lehmann, P. Wounding- and elicitor induced formation of coloured chalcones and flavans as phytoalexins in Hippeastrum x hortorum. Botanica Acta 109, 412-421, 1996

Wink, M., Mende, P. Uptake of lupanine by alkaloid-storing epidermal cells of Lupinus polyphyllus. Planta Medica 53, 465-469,1987

Wink, M., Perrey, R., Schneider, M.,Warskulat, U. von Borstel, K.,Mende, P. : Alkaloid metabolism and gene expression in cell suspension cultures of Lupinus polyphyllus and L. hartwegii. In "Plant tissue culture and gene manipulation for breeding and formation of phytochemicals" (K.Oono et al. eds.) pp 101-119 ,1992

Wink, M. Alkaloids: Properties and Determination In Trugo, L. & Finglas, P.M.,eds.; Encyclopedia of food science and nutrition. Academic Press, 2003

Wink, M. Alkaloids: Toxicology. In Trugo, L. & Finglas, P.M.,eds.; Encyclopedia of food science and nutrition. Academic Press, 2003

Wink, M. Composition of the spent culture medium. I. Time-course of ethanol formation and the excretion of hydrolytic enzymes into the culture medium of suspension-cultured cells of Lupinus polyphyllus. J. Plant Physiol. 121, 287-293, 1985

Wink, M. Evidence for an extracellular lytic compartment of plant cell suspension cultures. The cell culture medium. Naturwissenschaften 71, 635, 1984

Wink, M. Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective. Phytochemistry 64, 3-19, 2003

Wink, M. Genes of secondary metabolism: Differential expression in plants and in vitro cultures and functional expression in genetically transformed microorganisms In: Primary and Secondary Metabolism of Plant Cell Cultures, ed. by W.G.W. Kurz, Springer-Verlag Berlin, 239-251, 1989

Wink, M. Induction of alkaloid formation in plant cell cultures.In: Highlights of modern biochemistry (ed. A. Kotyk, J. Skoda, V. Paces, V. Kostka) pp. 1183-1192, 1989

Wink, M. Introduction: biochemistry, role and biotechnology of secondary metabolites. In: "Biochemistry of plant secondary metabolism" M. Wink, ed., Sheffield Academic Press and CRC Press , Annual Plant Reviews Vol. 2, pp 1-16, 1999

Wink, M. Introduction: biochemistry, role and biotechnology of secondary metabolites. In: In "Function of Plant secondary metabolites and their exploitation in biotechnology" M. Wink, ed., Sheffield Academic Press and CRC Press, Annual Plant Reviews, Vol. 3, pp. 1-16, 1999

Wink, M. Metabolism of quinolizidine alkaloids in plants and cell suspension cultures: Induction and degradation. In: Primary and secondary metabolism of plants and cell cultures (Eds.: K.H. Neumann, W. Barz & E. Reinhard), Springer, Berlin, pp 107-116, 1985

Wink, M. N-Methylation of quinolizidine alkaloids: An S-adenosyl-L-methionine: cytisine N-methyltransferase from Laburnum anagyroides plants and cell cultures of L. alpinum and Cytisus canariensis. Planta 161, 339-344, 1984

Wink, M. Physiology of secondary product formation in plants. In: Secondary products from plant tissue culture (Edt. B.V. Charlwood, M.J.C. Rhodes) Clarendon Press, Oxford, 23-41, 1990

Wink, M. Physiology of the Accumulation of Secondary Metabolites with Special Reference to Alkaloids.In: Cell culture and somatic cell genetics of plants.Vol. 4: Cell culture in Phytochemistry (F.Constabel, I, Vasil, eds), Academic press, pp. 17-41, 1987

Wink, M. Phytochemical Diversity of Secondary Metabolites. Enzyclopedia of Plant & Crop Science 2004

Wink, M. Plant breeding: Importance of plant secondary metabolites for protection against pathogens and herbivores.Theoretical Applied Genetics 75, 225-233, 1988

Wink, M. Production and application of phytochemicals from an agricultural perspective. In "Phytochemistry and agriculture, T. A. van Beek, H. Breteler, eds.) Proc. Phytochem. Soc. Europe Vol 34, pp 171-213, Oxford University Press, 1993

Wink, M. Special nitrogen metabolism, In "Plant Biochemistry" (P.M. Dey & J.B. Harborne, eds.), Academic Press, San Diego, London, 439-486, 1997

Wink, M. Storage of quinolizidine alkaloids in epidermal tissues. Z. Naturforschung; Journal of Bioscince 41c, 375-380, 1986

Wink, M.: The endosymbionts of Glossina morsitans and G.palpalis: Cultivation experiments and some physiological properties. Acta Tropica 36, 215-222, 1979

Wink, M. Why do lupin cell cultures fail to produce alkaloids in large quantities? Plant Cell, Tiss. Org. Cult. 8,103-111, 1987

Wink, M., Wehrle, H. PCR im medizinischen und biologischen Labor. GIT-Verlag, Darmstadt, 295 pp, 1994

Wink, M. Hormonal growth stimulation and inhibition of pupal cells of the tsetse fly, Glossina morsitans in vitro. Naturwissenschaften 64, 226, 1977

Wink, M. Production of plant secondary metabolites by plant cell cultures in relation to the site and mechanism of their accumulation.in: Plant vacuoles. Their importance in solute compartmentation in cells and their application in plant biotechnology. (B.Marin, ed.). NATO Asi Ser. 134, 477-484, 1987

Zayed R., Wink, M. El-Shamy, H.In vitro Organogenesis and Alkaloid accumulation in Datura innoxia. Z. Naturforschung; J. Biosciences; 61c, 560-564, 2006

Zayed, R., Wink, M. Induction of tropane alkaloid formation hairy root cultures of Brugmansia suaveolens. Z. Naturforschung; Journal of Bioscince. 59c, 863-867, 2004

Zayed, R., Wink, M. ß-Carboline and quinoline alkaloids in root cultures and intact plants of Peganum harmala. Z. Naturforschung; Journal of Bioscience 60c, 451-458, 2005

Zayed, R.; Abbas, F.; Wink, M. Study of alkaloid metabolism during seedling development in Hyoscyamus muticus L. and Hyoscyamus Niger L. and elicitation of tropane alkaloid formation in root cultures of Hyoscyamus niger. Egyptian Journal of Pharmaceutical Sciences,44, 293-306, 2003

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