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Faculty of Biosciences > Institute of Pharmacy and Molecular Biotechnology > IPMB, Department Biology 
Publikationen Prof. Dr. M. Wink 
Pharmacology, Phytomedicine

Chrubasik, S. & Wink, M. (Hrgb) Rheumatherapie mit Phytopharmaka. Hippokrates-Verlag, 1997

Chrubasik, S., Sporer, F., Dillmann-Marschner, R., Friedmann, A., Wink, M. Physicochemical properties of harpagoside and its in vitro release from Harpagophytum procumbens extract tablets. Phytomedicine 6, 469-473, 2000

Chrubasik, S., Wink, M., Traditional herbal therapy for the treatment of rheumatic pain: preparations from Devil's Claw and stinging nettle. Pain Digest 8, 94-101, 1998

Chrubasik, S., Wink, M. (Hrgb): Phytopharmaka bei Störungen und Erkrankungen des Nervensystems, 1998

Chrubasik, S., Wink, M. Treatment of osteoarthritic pain with herbal drugs. In "Management of Pain. A world perspective III., J.A. de Vera, W. Parris & S. Erdine eds.Monduzzi, Bologna, pp. 507-514, 1998

Chrubasik, S.& Wink, M.: Zur pharmakologischen Wirkung der Teufelskralle (Harpagophytum procumbens) Forsch. Komplementärmed. 2, 323-325, 1995

Efferth, T., Yu-jie Fu, Yuangang Zu, Schwarz, G., Newman, D., Wink, M. Molecular Target-guided Tumor Therapy with Natural Products Derived from Traditional Chinese Medicine. Current Medicinal Chemistry, 14, 2024-2032, 2007

Efferth, T., Wink, M. DNA polymorphisms affecting chemosensitivity towards drugs. B Bonavida, El-Domiaty, M. M., M. Wink, M. M Abdel Aal, M. M. Abou-Hashem, R. H. Abd-Alla Antihepatotoxic Activity and Chemical Constituents of Buddleia asiatica Lour

Friedrich, O., von Wegner, F., Wink, M., Fink, R. H. A. Na+- and K+-channels as molecular targets of the alkaloid ajmaline in enzymatically isolated amphibian skeletal muscle fibres. British Journal of Pharmacology 151, 63-74, 2007

Pakalapati, G. and Wink, M. Study of apolipoprotein A-I expression in ovariectomized female rats by proteomics Pakalapatia, G., Wink, M., Lib, L., Gretzb, N., Koch, E. Influence of Red Clover (Trifolium pratense) Isoflavones on Gene and Protein Expression Profiles in Liver of Ovariectomized Rats. Phytomedicine (submitted)

Makkar, HPS, Becker, K., Sporer, F. and Wink, M. Studies on nutritive potential and toxic constituents of different provenances of Jatropha curcas. J. Agric Food Chem. 45, 3152-3157, 1997

Ibieta, P. & Wink, M. Binding of flavonoids from Sophora flavescens to rat uterine estrogen receptor. Planta Medica 71, 1065-1068, 2005

Ibieta, P. A., Zu, Y., Fu, Y.-J., Wink, M. Binding of phytoestrogens to estrogen receptor and human sex hormone-binding globulin. Z. f. Naturforschung; Journal of Bioscience 60c, 649-656, 2005

Körper, S., Wink, M., & Fink, R. A. Differential effects of alkaloids on sodium currents of isolated single skeletal muscle fibres. FEBS Lett. 436, 251-255, 1998

Liu, S.Y., Sporer, F., Wink, M., Jourdane, J., Hennig, R., Li, Y.L. and A. Ruppel: Anthraquinones in Rheum palmatum and Rumex dentatus (Polygonaceae) and phorbolesters from Jatropha curcas (Euphorbiaceae) with molluscicidal activity against schistosomias vector snails Oncomelania, Biomphalaria and Bulinus. Tropical Medicine and International Health 2, 179-188, 1997

Ma Y. and Wink, M. The Beta-Carboline Alkaloid Harmine inhibits BCRP and Can Reverse Resistance to the Anticancer Drugs Mitoxanthrone and Camptothecin (submitted)

Ma, Y., Wink, M.: Lobeline, a piperidine alkaloid from Lobelia can reverse P-gp dependant multidrug resistance in tumor cells. Phytomedicine (published online, 2008)

Merschjohann, K., Sporer, F., Steverding, D., Wink, M., In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense. Planta Medica 67, 623-627, 2001

Minas, S., Wink, M. Wirkung und Wirkmechanismen von Phyto-Psychopharmaka. In Phytopharmaka bei Störungen und Erkrankungen des Nervensystems. (S. Chrubasik & M. Wink, eds) pp. 51-64, 1998

Möller, M., J. Weiss & M. Wink: Reduction of cytotoxicity of the alkaloid emetine through P-glycoprotein in human Caco-2 cells and leukemia cell lines. Planta Medica 72, 1121-1126, 2006

Möller, M., Suschke, U., Nolkemper, S., Schneele, J. Sporer, F., Reichling, J., Wink, M. Antibacterial, antiviral, antiproliferative and apoptosis inducing properties of Brackenridgea zanguebarica (Ochnaceae). Journal of Pharmacy and Pharmacology 58, 1131-1138, 2006

Möller, M., Herzer, K., Wenger, T., I. Herr & M. Wink The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukaemia cells.Oncology Reports, 14, 737-744, 2007

Möller, M., Wink, M. Characteristics of apoptosis induction by the alkaloid emetine in human tumor cell lines. Planta medica 73, 1-8, 2007

Nkemgu-Njinkeng, J., Rosenkranz, V., Wink, M., Steverding, D. Antitrypanosomal activity of proteasome inhibitors. Antimicrobial agents & Chemotherapy 46, 2038-2040, 2002

Rosenkranz, V., Wink, M. Alkaloids can induce apoptosis in trypanosomes (Trypanosoma b. brucei). Molecules (submitted)

Rosenkranz, V., Wink, M. Induction of apoptosis by alkaloids in human promyelotic HL-60 cells. Z. Naturforschung- J. Bioscience 62c, 458-466, 2007

Rug, M., Sporer, F., Wink, M., Liu, S.Y., Henning, R., & Ruppel, A. Molluscicidal properties of J. curcas against vector snails of the human parasites Schistosoma mansoni and S. japonicum. In: Biofuel and Industrial Products from Jatropha curcas. (G.M. Gübitz, M. Mittelbach & M. Trabi, eds.) pp 227-232, Dbv-Verlag Univ. Graz, 1997

Abbas, S., Wink, M., Epigallocatechin Gallate (EGCG) from Green Tea (Camellia sinensis) Increases Lifespan and Stress Resistance in Caenorhabditis elegans.Planta Medica, submitted

Schmeller, T. & Wink, M. Utilization of alkaloids in modern medicine: In "Alkaloids: Biochemistry, ecology and medicinal applications; M.F. Roberts, & M. Wink, eds, pp. 435-459, Plenum, New York, 1998

Schmeller, T. , Sporer, F. Sauerwein, M., Wink, M. Binding of tropane alkaloids to nicotinic and muscarinic receptors. Pharmazie 50, 493-495, 1995

Schmeller, T., Latz-Brüning, B. & Wink, M. Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores. Phytochemistry 44, 257-266, 1997

Schmeller, T., Sauerwein, M., Sporer, F., Müller, W.E., & Wink, M: Binding of quinolizidine alkaloids to nicotinic and muscarinic receptors. J. Natural Products 57, 1316-1319, 1994

Toth, J. & Wink, M.Isoflavone in Lupinen: Mögliche gesundheitliche Konsequenzen. In "Lupinen in Forschung und Praxis" (Wink, M. ed.), pp. 53-63, Heidelberg, 1998

van Wyk, B.-E., C. Wink, M. Wink (2004) Handbuch der Arzneipflanzen. Wissenschaftliche Verlagsgesellschaft; 480 Seiten; 2. Aufl. 2005

van Wyk, B.-E.; Wink, M. Medicinal plants of the World. Briza; Pretoria, 480 Seiten; 2004

Wahrendorf, M.-S., Sporer, F, Wink, M. Anti-inflammtions assays. J. Fleurentin, J.-M. Pelt, G. Mazars ; Des sources du savoir aux médicaments du futur. IRD. Editions, pp 399-401, 2002

Wahrendorf, M.-S., Wink, M. Pharmacologically active natural products in the defence secretion of Palembus ocularis (Tenebrionidae, Coleoptera). J. Ethnopharmacology 106, 51-56, 2006

Wink , M., & Twardowski,T.: Allelochemical properties of alkaloids. Effects on plants, bacteria and protein biosynthesis. In: Allelopathy: Basic and applied aspects. (S.J.H. Rizvi and V. Rizvi, eds), Chapman & Hall, London, 129-150, 1992

Wink, M. & Schimmer, O. Modes of action of defensive secondary metabolites. In "Function of Plant secondary metabolites and their exploitation in biotechnology" M. Wink, ed., Sheffield Academic Press and CRC Press, Annual Plant Reviews, Vol. 3, pp.17-133, 1999

Wink, M. & Van Wyk, B.-E. Mind-altering and poisonous plants of the world. BRIZA and Timber Press 2008

Wink, M. Modes of action of alkaloids: In "Alkaloids: Biochemistry, ecology and medicinal applications; M.F. Roberts, & Wink, M. eds, pp. 301-326, Plenum, New York, 1998

Wink, M. Die Verwendung pflanzlicher Vielstoffgemische in der Phytotherapie: Eine evolutionäre Sichtweise. Phytotherapie 5, 33-39, 2005

Wink, M. History of penicillin. Pharmacy International-Trends in Pharmacy & Pharmaceutical Sciences 1, (9) 8, 1980

Wink, M. Interference of alkaloids with neuroreceptors and ion channels. In Bioactive natural products. Atta-Ur-Rahman (Ed.), Elsevier pp. 3-129, Vol 11, 2000

Wink, M. Molecular modes of action of cytotoxic alkaloids- From DNA intercalation, spindle poisoning, topoisomerase inhibition to apoptosis and multiple drug resistance. In "The Alkaloids, (G. Cordell, ed.), Elsevier, Vol. 64, 1-48, 2007

Wink, M. Phytopharmaka versus Synthetika. In Rheumatherapie mit Phytopharmaka (Chrubasik, S. & Wink, M., eds):pp. 38-55; Hippokrates Verlag 1997

Wink, M. Phytopharmaka: Evolutionäre Grundlagen und rationale Anwendungen. Drogenreport 11, 22-28, 1998

Wink, M. Sind Nahrungsergänzungsmittel sinnvoll? Umwelt Direkt 18, 6-7, 2006

Wink, M. Wie funktionieren Phytopharmaka? Wirkmechanismen der Vielstoffgemische. Zeitschrift für Phytotherapie 26, 271-274, 2005

Wink, M., Latz-Brüning, B., & Schmeller, T., Biochemical effects of allelopathic alkaloids. In "Principles and Practices in Plant Ecology" (Inderjit, K.M.M. Dakshini & C.L. Foy, eds.) CRC Press, Boca Raton, USA pp. 411-438, 1999

Wink, M., Latz-Brüning, B.: Allelopathic properties of alkaloids and other natural products: Possible modes of action. In Allelopathy: Organisms, processes and applications" Inderjit, K.M.M. Dakshini, F.A. Einhellig, eds; ACS Symp. Ser.582, 117-126, Amer. Chem. Soc. Washington, DC, 1995

Wink, M., Schmeller, T., & Latz-Brüning, B. Modes of action of allelochemical alkaloids: Interaction with neuroreceptors, DNA and other molecular targets. J. Chemical Ecology 24, 1881-1937, 1998

Wink, M., Wink, C., van Wyk, B.-E. Handbuch giftiger und psychoaktiver Pflanzen, WVG 2008

Wink, M. Wirkung und Kulturgeschichte psychotroper Pflanzen und Drogen. In "Rausch" Heidelberger Jahrbücher Vol. 43, pp 27-90, 1999

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last update: 17.07.2008