We study the nuclear pore complex and the mechanism of nuclear export of RNA. This work has also involved investigation of other cell machines, especially those that assemble and export mRNAs and ribosomal subunits.

These investigations have led to the genetic and biochemical dissection of the yeast nuclear pore complex, the identification and characterization of the primary nuclear mRNA export receptor and defining how it is coupled to transcription and chromatin modifying machineries, and the dissection of the complicated biogenesis and export pathway of ribosomal subunits.

Overall this work has given insight into the structure and function of macromolecular machines that are composed of a large number of subunits and transiently interacting factors.We recently sequenced the genome of a thermophilic eukaryote, which will enable us to solve the structure of difficult proteins and complexes.