Molecular anatomy of the developing neuromuscular junction
Department of Cellphysiology
MPI for Medical Research
The formation of the neuromuscular junction involves reciprocal interactions between the presynaptic nerve terminal and the postsynaptic muscle fiber. We generate genetically manipulated mouse models to modulate synaptic activity by changing the functional properties of the postsynaptic signaltransducers, the acetylcholine receptors (AChR) or by inactivating conditionally other synaptic regulators. These studies lead to the analysis of disorders that are caused by defective neuromuscular junctions.
Structure of the Group
|Group Leader:||Veit Witzemann|
|Postdoctoral fellows:||Frédéric Chevessier, Pessah Yamapolsky|
|Undergraduates:||Ulrike Mersdorf, Susi Zobeley|