Publications

Peer-reviewed publications

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2000

Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., and Schibler, U. (2000). Glucocorticoid hormones can reset circadian time in peripheral tissues but not in the suprachiasmatic nucleus. Science 289, 2344-2347.

Beißbarth, T., Fellenberg, K., Brors, B., Arribas-Prat, R., Boer, J.M., Hauser, N.C., Scheideler, M., Hoheisel, J.D., Schütz, G., Poustka, A., and Vingron, M. (2000). Processing and quality control of DNA array hybridization data. Bioinformatics 16, 1014-1022.

Berger, S., Bleich, M., Schmid, W., Greger, R., and Schütz, G. (2000). Mineralocorticoid receptor knockout mice: lessons on Na+ metabolism. Kidney International 57, 1295-1298.

Berton, T. R., Wang, X.-J., Zhou, Z., Kellendonk, C., Schütz, G., Tsai, S., and Roop, D. R. (2000). Characterization of an inducible, epidermal-specific knockout system: differential expression of lacZ in different Cre reporter mouse strains. Genesis 26, 160-161.

Gass, P., Kretz, O., Wolfer, D.P., Berger, S., Tronche, F., Reichardt, H.M., Kellendonk, C., Lipp, H.-P., Schmid, W., and Schütz, G. (2000). Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice. EMBO reports 1, 447-451.

Karst, H., Karten, Y. J. G., Reichardt, H. M., de Kloet, E. R., Schütz, G., and Joels, M. (2000). Corticosteroid actions in hippocampus require DNA-binding of glucocorticoid receptors. Nat Neurosci 3, 977-978.

Kellendonk, C., Opherk, C., Anlag, K., Schütz, G., and Tronche, F. (2000). Hepatocyte-specific expression of Cre recombinase. Genesis 26, 151-153.

Mantamadiotis, T., Taraviras, S., Tronche, F., and Schütz, G. (2000). PCR-based strategy for genotyping mice and ES cells harboring loxP sites. Polymorphism Detection and Analysis (ed. J. Burczak and E. Mardis), Chapter 19, Eaton Publ.; 201-206.

Otto, C., Schütz, G., Niehrs, C., and Glinka, A. (2000). Dissecting GHRH- and PACAP-mediated signalling in Xenopus. Mech Dev 94, 111-116.

Rammes, G., Steckler, T., Kresse, A., Schütz, G., Zieglgänsberger, W., and Lutz, B. (2000). Synaptic plasticity in the basolateral amygdala and fear conditioning in transgenic mice expressing dominant-negative cAMP response element binding protein (CREB) in forebrain. Eur. J. Neuroscience 12, 2534-2546.

Reichardt, H. M., Tronche, F., Berger, S., Kellendonk, C., and Schütz, G. (2000). New insights into glucocorticoid and mineralocorticoid signalling - lessons from gene targeting. Hormones & Signalling, Advances in Pharmacology  47 (ed. B. O´Malley), Academic Press, San Diego.1-21.

Reichardt, H. M., Tuckermann, J. P., Bauer, A., and Schütz, G. (2000). Molecular genetic dissection of glucocorticoid receptor function in vivo. Z. Rheumatol. 59, Suppl. 2, II-1 - II-5.

Reichardt, H.M., Tronche, F., Bauer, A., and Schütz, G. (2000). Molecular genetic analysis of glucocorticoid signalling using the Cre/loxP-system. Biol. Chem. 381, 961-964.

Reichardt, H. M., Umland, T., Bauer, A., Kretz, O., and Schütz, G. (2000). Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock. Mol. Cell Biol. 20, 9009-9017.

Schuetz, E. G., Schmid, W., Schütz, G., Brimer, C., Yasuda, K., Kamataki, T., Bornheim, L., Myles, K., and Cole, T.J. (2000). The glucocorticoid receptor is essential for induction of cytochrome P-4502B by steroids but not for drug or steroid induction of CYP3A or P450 reductase in mouse liver. Drug Metab. Dispos. 28, 268-278.

Takei, N., Torres, E., Yuhara, A., Jongsma, H., Otto, C., Korhonen, L., Abiru, Y., Skoglösa, Y., Schütz, G., Hatanaka, H., Sofroniew, M.V., and Lindholm, D. (2000). Pituitary adenylate cyclase-activating polypeptide promotes the survival of basal forebrain cholinergic neurons in vitro and in vivo: comparison with effects of nerve growth factor. Eur. J. Neurosci. 12, 2273-2280.

Taraviras, S., Mantamadiotis, T., Dong-Si, T., Mincheva, A., Lichter, P., Drewes, T., Ryffel, G. U., Monaghan, A. P., and Schütz, G. (2000). Primary structure, chromosomal mapping, expression and transcriptional activity of the murine Hepatocyte Nuclear Factor 4gamma (mHNF4gamma) gene. Biochim. et Biophys. Acta: Gene Structure and Expression 1490, 21-32.

Wagner, B.L., Bauer, A., Schütz, G., and Montminy, M. (2000). Stimulus-specific interaction between activator-coactivator cognates revealed with a novel complex-specific anteriserum. J. Biol. Chem. 275, 8263-8266.

2001

Casanova, E., Fehsenfeld, S., Mantamadiotis, T., Lemberger, T., Greiner, E., Stewart, A.F., and Schütz, G. (2001). A CamKIIa iCre BAC allows brain-specific gene inactivation. Genesis 31, 37-42.

Herzig, S., Long, F., Jhala, U., Hedrick, S., Quinn, R., Bauer, A., Schütz, G., Yoon, C., Puisgever, P., Spiegelman, B., and Montminy, M. (2001). CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413, 179-183.

Le Minh, N., Damiola, F., Tronche, F., Schütz, G., and Schibler, U. (2001). Glucocorticoid signaling inhibits food-induced phase-shifting of peripheral circadian oscillators. EMBO J. 20, 7128-7136.

Otto, C., Kovalchuk, Y., Wolfer, D. P., Gass, P., Martin, M., Zuschratter, W., Gröne, H.-J., Kellendonk, C., Tronche, F., Maldonado, R., Lipp, H.-P., Konnerth, A., and Schütz, G. (2001). Impairment of mossy fiber long-term potentiation and associative learning in pituitary adenylate cyclase activating polypeptide type I receptor-deficient mice.
J. Neurosci. 21, 5520-5527.

Otto, C., Martin, M., Wolfer, D.P., Lipp, H.-P., Maldonado, R., and Schütz, G. (2001).
Altered emotional behavior in PACAP-type-I-receptor deficient mice. Mol. Brain Res. 92, 78-84.

Reichardt, H. M., Tuckermann, J. P., Göttlicher, M., Vujic, M., Weih, F., Angel, P., Herrlich, P., and Schütz, G. (2001). Repression of inflammatory responses in the absence of DNA-binding by the glucocorticoid receptor. EMBO J. 20, 7168-7173.

Reichardt, H.M., Horsch, K., Gröne, H.-J., Kolbus, A., Beug, H., Hynes, N., and Schütz, G. (2001). Mammary gland development and lactation are controlled by different glucocorticoid rceptor activities. Eur. J. Endocrinol. 145, 519-527.

Schulz-Baldes, A., Berger, S., Grahammer, F., Warth, R., Goldschmidt, I., Peters, J., Schütz, G., Greger, R., and Bleich, M. (2001). Induction of the epithelial NA+ channel via glucocorticoids in mineralocorticoid receptor knockout mice. Pflügers Arch. Eur. J. Physiol. 443, 297-305.

2002

Behrens, A., Sibilia, M., David, J.-P., Schütz, G., and Wagner, E.F. (2002). Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J. 21, 1782-1790.

Bleckmann, S., Blendy, J.A., Rudolph, D., Monaghan, A.P., Schmid, W., and Schütz, G. (2002).ATF-1 and CREB are important for cell survival during early mouse development. Mol. Cell. Biol. 22, 1919-1925.

Casanova, E., Lemberger, T., Fehsenfeld, S., Greiner, E., and Schütz, G. (2002). Rapid localisation of a gene within BACs and PACs. BioTechniques 32, 240-242.

Casanova, C., Fehsenfeld, S., Greiner, E., Stewart, A.F., and Schütz, G. (2002). Construction of a conditional allele of RSK-B/MSK2 in the mouse. Genesis 32, 158-160.

Casanova, E., Fehsenfeld, S., Greiner, E., Stewart, A.F., and Schütz, G. (2002). Conditional mutagenesis of CamKIV. Genesis 32, 161-164.

Coffinier, C., Gresh, L., Fiette, L., Tronche, F., Schütz, G., Babinet, C., Pontoglio, M., Yaniv, M., and Barra, J. (2002). Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1b. Development 129, 1829-1838.

Gau, D., Lemberger, T., von Gall, C., Kretz, O., Le Minh, N., Gass, P., Schmid, W., Schibler, U., Korf, H.W., and Schütz, G. (2002). Phosphorylation of CREB Ser-142 regulates light-induced phase shifts of the circadian clock . Neuron 34, 245-253.

Kellendonk, C., Gass, P., Kretz, O., Schütz, G., and Tronche, F. (2002). Corticosteroid receptors in the brain: gene targeting studies. Brain Res. Bulletin 57, 73-83.

Kellendonk, C., Eiden, S., Kretz, O., Schütz, G., Schmidt, I., Tronche, F., and Simon, E. (2002). Inactivation of the glucocorticoid receptor in the nervous system affects energy accumulation. Endocrinology 143, 2333-2340.

Kellendonk, C., Tronche, F., Reichard, H.M., Bauer, A., Greiner, E., Schmid, W., and Schütz, G. (2002). Analysis of glucocorticoid receptor function in the mouse by gene targeting, in Recent Advances in Glucocorticoid Receptor Action (eds. A.C.B. Cato, H. Schäcke, K. Asadullah). Proceedings of the Ernst Schering Research Foundation Workshop Series 40, 305-318.

Kingsley-Kallesen, M., Mukhopadhyay, S.S., Wyszomierski, S.L., Schanler, S., Schütz, G., and Rosen, J.M. (2002). The mineralocorticoid receptor compensates for the loss of the
glucocorticoid receptor at specific stages of mammary gland development. Mol. Endocrinol. 16, 2008-2018.

Limbourg, F.P., Huang, Z., Plumier, J.-C., Simoncini, T., Fujioka, M., Tuckermann, J., Schütz, G., Moskowitz, M.A., and Liao, J.K. (2002). Enhancement of cerebral blood flow and stroke protection mediated by non-nuclear actions of the glucocorticoid receptor. J. Clin. Invest. 110, 1729-1738.

Mantamadiotis, T., Lemberger, T., Bleckmann, S., Kern, H., Kretz, O., Martin-Villalba, A., Tronche, F., Kellendonk, C., Gau, D., Kapfhammer, J., Otto, C., Schmid, W., and Schütz, G. (2002). Disruption of CREB function in brain leads to neurodegeneration. Nat. Genet. 31, 47-54.

Wintermantel, T.M., Mayer, A.K., Schütz, G., and Greiner, E.F. (2002). Targeting mammary epithelial cells using a bacterial artificial chromosome. Genesis 33, 125-130.

2003

Balschun, D., Wolfer, D.P., Gass, P., Mantamadiotis, T., Welzl, H., Schütz, G., Frey, J.U., nd Lipp, H.-P. (2003). Does CREB have a pivotal role in hippocampal synaptic plsticity and hippocampus-dependent memory? J. Neurosci. 23, 6304-6314.

Beißbarth, T., Borisevich, I., Hörlein, A., Kenzelmann, M., Klewe-Nebenius, A., Klären, R., Korn, B., Schmid, W., Vingron, M., and Schütz, G. (2003). Analysis of CREM-dependent gene expression during mouse spermatogenesis. Mol. Cell. Endocrinol. 212, 29-39.

Casanova, E., Lemberger, T., Fehsenfeld, S., Mantamadiotis, T., and Schütz, G. (2003). Alpha complementation in the Cre recombinase enzyme. Genesis 37, 25-29.

Deroche-Gamonet, V., Sillaber, I., Aouizerate, B., Izawa, R., Jaber, M., Ghozlan, S., Kellendonk, C., Le Moal, M., Spanagel, R., Schütz, G., Tronche, F., and Piazza, P.V. (2003). Glucocorticoid receptors as a potential target to reduce cocaine abuse. J. Neurosci. 23, 4785-4790.

Greiner, E., Wintermantel, T., and Schütz, G. (2003). Steroid Receptors. Vol. 159: "Transgenic Models in Pharmacology", Handbook of Experimental Pharmacology (ed. S. Offermanns and L. Hein), Springer-Verlag Heidelberg, 575-606.

Greiner, E. Berger, S., and Schütz, G. (2003). Genetic dissection of gluco- and mineralocorticoid receptor function in mice. SCOPE/IUPAC International Symposium on Endocrine Active Substances, Nov. 17-21, 2002. Pure Appl. Chem. 75, Nos. 11-12, pp. 1699-1707.

Marsicano, G., Goodenough, S., Monory, K., Hermann, H., Eder, M., Cannich, A., Azad, S.C., Cascio, M.G., Ortega Gutiérrez, S., van der Stelt, M., López-Rodriguez, M.L., Casanova, E., Schütz, G., Zieglgänsberger, W., Di Marzo, V., Behl, C., and Lutz, B. (2003). CB1 receptors mediate on-demand defense against excitotoxicity. Science 302, 84-88.

Martin, M., Otto, C., Santamarta, M.T., Torrecilla, M., Pineda, J., Schütz, G., and Maldonado, R. (2003). Morphine withdrawal is modified in pituitary adenylate cyclase-activating polypeptide-type-I-receptor-deficient mice. Brain Res. 110, 109-118.

Müller, F.U., Lewin, G., Mátus, M., Neumann, J., Riemann, B., Wistuba, J., Schütz, G., and Schmitz, W. (2003). Impaired cardiac contraction and relaxation and decreased expression of sarcoplasmic Ca2+-ATPase in mice lacking the CREM gene. The FASEB J. 17, 103-105.

Streetz, K.,  Wüstefeld, T., Leifeld, L., Tacke, F., Tronche, F., Graw, A., Kamino, K., Kreipe, H., Schütz, G., Manns, M.P., Müller, W., and Trautwein, C. (2003). Lack of GP130 expression promotes hepatic injury. Gastroenterology 125, 532-542.

2004

Baumann, S., Kyewski, B., Bleckmann, S.C., Greiner, E., Rudolph, D., Schmid, W., Ramsay, R.G., Krammer, P., Schütz, G., and Mantamadiotis, T. (2004). CREB function is required for normal thymic cellularity and post-irradiation recovery. Eur. J. Immunol.34, 1961-1971.

Florin, L., Alter, H., Gröne, H.-J., Szabowski, A., Schütz, G., and Angel, P. (2004). CRE recombinase mediated gene targeting of mesenchymal cells. Genesis 38, 139-144.

Kenzelmann, M., Klären, R., Hergenhahn, M., Ernst, T., Gröne, H.-J., Schmid, W., and Schütz, G. (2004). High accuracy amplification of nanogram total RNA amounts for gene profiling. Genomics 83, 550-558.

Opherk, C.,Tronche, F., Kellendonk, C., Kohlmüller, D., Schulze, A., Schmid, W., and Schütz, G. (2004) Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus. Mol. Endocrinol. 18, 1346-1353.

Otto, C., Hein, L., Brede, M., Jahns, R., Engelhardt, S., Gröne, H.-J., and Schütz, G. (2004). Pulmonary hypertension and right heart failure in PACAP-type I-receptor-deficient mice. Circulation 110, 3245-3251.

Parrish, M., Ott, T., Lance-Jones, C., Schütz, G., Schwäger-Nickolenko, A., and Monaghan, A.P. (2004). Loss of the sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethality. Mol. Cell. Biol. 24, 7102-7112.

Roy, K., Kuznicki, K., Wu, Q., Sun, Z., Bock, D., Schütz, G., Vranich, N., and Monaghan, A.P. (2004). The tlx gene regulates the timing of neurogenesis in the cortex. J. Neurosci. 24, 8333-8345

Tronche, F., Opherk, C., Kellendonk, C., Reichardt, H.M., Stangl, K., Gau, D., Schwake, L., Hoeflich, A., Schmid, W. Beug, H., Moriggl, R., and Schütz, G. (2004). Glucocorticoid receptor function in hepatocytes is essential to promote post-natal body growth. Genes Dev. 18, 492-497.

Valverde, O., Mantamadiotis, T., Torrecilla, M., Ugedo, L., Pineda, J., Bleckmann, S., Gass, P., Kretz, O., Mitchell, J.M., Maldonado, R., and Schütz, G. (2004). Dissociation between morphine physical dependence and motivational responses and increased anxiety-like behaviour in CREB deficient mice. Neuropsychopharmacology 29, 1122-1133.

Wettschureck, N., Moers, A., Hamalainen, T., Lemberger, T., Schütz, G., and Offermanns, S. (2004). Heterotrimeric G proteins of the Gq/11 family are crucial for the induction of maternal behavior in mice. Mol. Cel. Biol. 24, 8048-8054.

Wintermantel, T., Berger, S., Greiner, E.F., and Schütz, G. (2004). Genetic dissection of corticosteroid receptor function in mice. Hormone and Metabolic Res. 36, 387-391.

Zhang, Z., Hofmann, C., Casanova, E., Schütz, G., and Lutz, B. (2004). Generation of a conditional allele of the CBP gene in mouse. Genesis 40, 82-89.

Zink, M., Otto, C., Zörner, B., Zacher, C., Schütz, G., Henn, F.A., and Gass, P. (2004). Reduced expression of brain-derived neurotrophic factor in mice deficient for pituitary adenylate cyclase activating polypeptide type-I-receptor. Neuroscience Letters 360, 106-108.

2005

Alberti, S., Krause, S.M., Kretz, O., Philippar, U., Lemberger, T., Casanova, E., Wiebel, F., Schwarz, H., Frotscher, M., Schütz, G., and Nordheim, A. (2005). Neuronal migration in the murine rostral migratory stream requires SRF. PNAS 102, 6148-6153.

Baumann, S., Dostert, A., Novac, N., Bauer, A., Schmid, W., Fas, S.C., Krueger, A., Heinzel, T., Kirchhoff, S., Schütz, G., and Krammer, P.H. (2005). Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95-ligand gene by a glucocorticoid receptor dimer. Blood 106, 617-625. 

Giachino, C., De Marchis, S., Giampietro, C., Parlato, R., Perroteau, I., Schütz, G., Fasolo, A., and Peretto, P. (2005). cAMP response element-binding protein (CREB) regulates differentiation and survival of newborn neurons in the olfactory bulb. J. Neurosci. 25, 10105-10118.

Karst, H., Berger. S.. Turiault, M., Tronche, F., Schütz, G., and Joels, M. (2005). Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone. Proc. Natl. Acad. Sci. USA 102, 19204-19207.

Li, N., Zhang, Y., Naylor, M.J., Schatzmann, F., Maurer, F., Wintermantel, T., Schütz, G., Müller, U., Streuli, C.H., and Hynes, N. (2005). b1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. EMBO J. 24, 1942-1953.

Naylor, M.J., Li, N., Cheung, J., Lowe, E.T., Lambert, E., Marlow, R., Wang, P., Schatzmann, F., Wintermantel, T., Schütz, G., Clarke, A.R., Mueller, U., Hynes, N.E., and Streuli, C.H. (2005). Ablation of b1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation. J. Cell. Biol. 171, 717-728..

Ramanan, N., Shen, Y., Sarsfield, S.L., Lemberger, T., Schütz, G., Linden, D.J., and Ginty, D.D. (2005). SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. Nat. Neurosci. 8, 759-767.

Ridder, S., Chourbaji, S., Hellweg, R., Urani, A., Zacher, C., Schmid, W., Zink, M. Hörtnagl, H., Flor, H., Henn, F.A., Schütz, G., and Gass, P. (2005). Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. J. Neurosci. 25, 6243-6250.

Unsicker, K., Huber, K., Schütz, G., and Kalchheim, C. (2005). The chromaffin cell and its development. Neurochemical Research 30, 921-925.

Wintermantel, T. Berger, S., Greiner, E.F., and Schütz, G. (2005). Evaluation of steroid receptor function by gene targeting in mice. J. Steroid Biochem. and Mol. Biol. 93, 107-112.

Wintermantel, T.M., Bock, D., Fleig, V., Greiner, E.F., and Schütz, G. (2005). The epithelial glucocorticoid receptor is required for the normal timing of cell proliferation during mammary lobuloalveolar development but is dispensible for milk production. Mol. Endocrinol. 19, 340-349.

Yuan, X., Zhou, Y., Casanova, E., Kenzelmann, M., Kiss, E., Gretz, N., Gröne, H.-J., Schütz, G., and Grummt, I. (2005). Nucleolar disruption by inactivation of the RNA polymerase I transcription factor TIF-IA leads to cell cycle arrest and p53-mediated apoptosis. Mol. Cell 19, 77-87.

2006

Berger, S., Wolfer, D.P., Selbach, O., Alter, H., Reichardt, H.M., Erdmann, G., Chepkova, A.N., Welzl, H., Haas, H.L., Lipp, H.-P., and Schütz, G. (2006). Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity. Proc. Natl. Acad. Sci. USA 103, 195-200.

Knöll, B., Kretz, O., Fiedler, C., Alberti, S., Schütz, G., Frotscher, M., and Nordheim, A. (2006). Serum Response Factor controls neuronal circuit assembly in the hippocampus. Nat. Neurosci. 9, 195-204.

Mantamadiotis, T., Kretz, Ol, Ridder, S., Bleckmann, S.C., Bock, D., Gröne, H.-J., Malaterre, J., Dworkin, S., Ramsay, R.G., and Schütz, G. (2006). Hypothalamic 3´, 5´-cyclic adenosine monophosphate response element-binding protein loss causes anterior pituitary hypoplasia and dwarfism in mice. Mol. Endocrinol. 20, 204-211.

Parlato, R., Rieker, C., Turiault, M., Tronche, F., and Schütz, G. (2006). Survival of DA neurons is independent of CREM upregulation in absence of CREB. Genesis 44, 454-464.

Stanke, M., Duong, C.V., Pape, M., Geissen, M., Burbach, G., Deller, T., Gascan, H., Otto, C., Parlato, R., Schütz, G., and Rohrer, H. (2006). Target-dependent specification of the neurotransmitter phenotype: Cholinergic differentiation of sympathetic neurons is mediated in vivo by gp130 signaling. Development 133, 141-150.

Sutherland, KD., Alexander, W.S., Vaillant, F., Wintermantel, T.M., Schütz, G., Watson, C.J., Chodosh, L.A., Lindeman, G.J., and Visvader, J.E. (2006). C-myc is a central mediator of accelerated apoptosis and involution in mammary glands lacking suppressor of cytokine signalling-3. EMBO J. 25, 5805-5815. Epub 2006 Nov 30.

Wettschureck, N., van der Stelt, M., Tsubokawa, H., Krestel, H., Moers, A., Petrosino, S., Schütz, G., di Marzo, V., and Offermanns, S. (2006). Forebrain-specific inactivation of Gq/G11family G-proteins results in age-dependent epilepsy and impaired endocannabinoid formation. Mol. Cell. Biol. 26, 5888-5894.

Wintermantel, T.M., Campbell, R.E., Porteous, R., Bock, D., Gröne, H.-J., Todman, M.G., Korach, K.S., Greiner, E., Pérez, C.A., Schütz, G., and Herbison, A.E. (2006). Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone (GnRH) neurons and fertility. Neuron 52, 271-280.

Yaar, M., Wu, C., Park, H.-Y., Panova, I., Schütz, G., and Gilchrest, B.A. (2006). Bone morphogenetic protein-4: a novel modulator of melanogenesis. J. Biol. Chem. 281, 25307-25314.

2007

Bayo, P., Sanchis, A., Bravo, A., Buder, K., Tuckermann, J., Schütz, G. and Pérez, P. (2007). Glucocorticoid receptor is required for skin barrier competence. (Submitted).

Belz,  T., Liu, H.-K., Bock, D., Takacs, A., Vogt, M., Wintermantel, T., Brandwein, C., Gass, P., Geriner, E., and Schütz, G. (2007). Inactivation of the gene for the nuclear receptor tailless in brain preserving its function in the eye. European J. Neurosci. 26, 2222-2227.

Cali, G., Zannini, M., Rubini, P., Tacchetti, C., D´Andrea, B., Affuso, A., Wintermantel, T.,     Boussadia, O., Terracciano,D., Silberschmidt, D., Amendola, E., De Felice, M., Schütz, G., Kemler, R., Di Lauro, R., and Nitsch, L. (2007). Conditional inactivation of the E-cadherin gene in thyroid follicular cells affects gland development but does not impair junction formation. Endocrinology (in press).

Diaz-Ruiz, C., Parlato, R., Aguado, F., Martinez, A., Carmona, M.A., Bleckmann, S., Urena, J.M., Burgaya, F., Del Rio, J.A., Schütz, G., and Soriano, E. (2007). Regulation of neural migration and spontaneous neural activity by the CREB/CREM transcription factors. (Submitted).

Engblom, D., Kornfeld, J.-W., Schwake, L., Tronche, F., Reimann, A., Beug, H., Hennighausen, L., Moriggl, R., and Schütz, G. (2007). Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression. Genes Dev.21, 1157-1162.

Erdmann, G., Schütz, G., and Berger, S. (2007). Inducible gene inactivation in neurons of the adult mouse forebrain. BMC Neuroscience 8, 63.

Erdmann, G., Schütz, G., and Berger, S. (2007). Genetic disrsuption of the pituitary feedback loop of the HPA axis in mice causes lethality in the early postnatal period. (Submitted).

Gantois, I., Fang, K., Jiang, L. Babovic, D., Lawrence, A.J., Ferreri,V., Teper, Y., Jupp, B., Ziebell, J., Morganti-Kossmann, C.M., O´Brien, T.J., Nally, R., Schütz, G., Waddington, J., Egan, G., and Drago, J. (2007). Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior. Proc. Natl. Acad. Sci. USA 104, 4182-4187.

Grosse-Wilde, A., Bailey, S.L., Voloshanenko, O., Longton, G.M., Schaefer, U., Schütz, G., Greiner, E.F., Kemp, C.J., and Walczak, H. (2007). Identification of the apoptosis-inducing TRAIL receptor as a metastasis suppressor. (Submitted).

Hautmann, M., Friis, U., Desch, M., Todorov, V., Castrop, H., Segerer, F., Otto, C., Schütz, G., and Schweda, F.(2007). Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors. J. Am. Soc. Nephrol. 18, 1150-1156.

Kallifatidis, G., Beckermann, B.M., Groth, A., Schubert, M., Apel, A., Khamidjanov, A., Ryschich, E., Wenger, T., Wagner, W., Diehlmann, A., Saffrich, R., Eckstein, V., Krause, U., Mattern, J., Chai, M., Schütz, G., Ho, A.D., Gebhard, M.M., Büchler, M.W., Friess, H., Büchler, P., and Herr, I. (2007).  Improved lentiviral transduction of human mesenchymal stem cells for therapeutic intervention in pancreatic cancer. Cancer Gene Therapy (in press).

Kenzelmann, M., Maertens, S., Hergenhahn, M., Kueffer, S., Hotz-Wagenblatt, A., Li, L., Wang, S., Ittrich, C., Lemberger, T., Arribas-Prat, R., Jonnakuty, S., Hollstein, M., Schmid, W., Gretz, N., Gröne, H.-J., and Schütz, G. (2007). Microarray analysis of newly synthesized RNA in cells and animals. Proc. Natl. Acad. Sci. USA 104, 6164-6169.

Kero, J., Ahmed, K., Wettschureck, N., Tunaru, S., Wintermantel, T., Greiner, E., Schütz, G., and Offermanns, S. (2007). Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and goiter development. J. Clin. Invest. 117, 2399-2407.

Kirilov, M., Chai,  M., van der Hoeven, F., Kloz, U., Schmid, W., and Schütz, G. (2007). Germ line transmission and expression of an RNAi cassette in mice generated by a lentiviral vector system. Tansgenic Res. 2007 Aug 8; [Epub ahead of print].

Krysko, O., Hulshagen, L., Janssen, A., Schütz, G., Klein, R., De Bruycker, M., Espeel, M., Gressens, P., and Baes, M. (2007). Neocortical and cerebellar developmental abnormalities in conditions of selective elimination of peroxisomes from brain or from liver. J. of Neurosci. Res. 85, 58-72.

Lemberger, T., Rodriguez Parkitna, J., Engblom, D., and Schütz, G. (2007). CREB regulates activity-regulated transcription in a context-dependent manner and maintains normal neuronal cholesterol homeostasis. (Submitted).

Lemberger, T., Parlato, R., Dassesse, D., Westphal,  M., Casanova, E., Turiault, M., Tronche, F., Schiffmann, S.N., and Schütz, G. (2007). Expression of Cre recombinase in dopaminoceptive neurons. BMC Neuroscience 2007, 8:4 doi:10.1186/1471-2202-8-4.

Lewin, G., Basu, A., Matus, M., Rohsbach, S., Safronenko, A., Buchwalow, I., Engelhardt, S., Schütz, G., Schmitz, W., and Müller, F.U. (2007). Inactivation of transcription factor cAMP response element modulator (CREM) protects from b1-adrenoceptor-mediated cardiomyocyte hypertrophy, cardiac fibrosis and left ventricular dysfunction. The FASEB J. (in press).

Liu, H.-K., Belz, T., Bock, D., Takacs, A., Wu, H., Lichter, P., Chai, M., and Schütz, G. (2007). The nuclear receptor tailless (Tlx) is expressed in type B cells of the adult subventricular zone and required for their generation. (Submitted).

Monory, K., Blaudzun, H., Massa, F., Kaiser, N., Lemberger, T., Schütz, G., Wotjak, C.T., Lutz, B., and Marsicano, G. (2007). Genetic dissection of behavioural and autonomic effects of D9-tetrahydrocannabinol in mice. PLOS Biology 5, e269 [Epub ahead of print].

Muller, O., Pradervand, S., Berger, S., Centeno, G., Milet, A., Nicod, P., Pedrazzini, T., Tronche, F., Schütz, G., Chien, K., Rossier, B.C., and Firsov, D. (2007). Identification of corticosteroid-regulated genes in cardiomyocytes by serial analysis of gene expression.
Genomics 89, 370-377.

Parlato, R., Otto, C., Begus, Y., Stotz, S., and Schütz, G. (2007). Specific ablation of the transcription factor CREB in sympathetic neurons surprisingly protects against developmentally regulated apoptosis. Development 134, 1663-1670.

Ridder, S., Skowronek, M.H., Lang, S., Lipinski, S., Wessa, M., Kroll, A., Deuschle, M., Christmann, C., Gass, P., Schütz, G., Rietschel, M., Schumann, G., and Flor, H. (2007). Brain activation during fear conditioning in humans depends on genetic variations related to functioning of the hypothalamic-pituitary-adrenal axis. (Submitted).

Rieker, C., Parlato, R., Engblom, D., Schober, A., Kreiner, G., Stotz, S., Yuan, Xuejun, Grummt, I., and Schütz, G. (2007). Targeted disruption of nucleolar function in dopaminergic neurons leads to progressive parkinsonism. (Submitted).

Ronzaud, C., Loffing, J., Bleich, M., Gretz, N., Gröne, H.-J., Schütz, G., and Berger, S. (2007). Impairment of sodium balance in mice deficient for renal principal-cell mineralocorticoid receptor. J. Am. Soc. Nephrol. 18, 1679-1687.

Rougier, J.-S., Muller, O., Berger, S., Centeno, G., Schütz, G., Firsov, D., and Abriel, H. (2007). Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of calcium currents in cardiac myocytes. (Submitted).

Tuckermann, J.P., Kleiman, A., Moriggl, R., Spanbroek, R., Neumann, A., Illing, A., Clausen, B.E., Stride, B., Förster, I., Habenicht, A.J.R., Reichardt, H.M., Tronche, F., Schmid, W., and Schütz, G. (2007). Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy. J. Clin. Invest. 117, 1381-1390.

Wintermantel, T.M., Elzer, J., Herbison, A.E., Fritzemeier, K.-H., and Schütz, G. (2007). Genetic dissection of estrogen receptor signalling in vivo, in: Tissue-Specific Estrogen Action – Novel Mechanisms, Novel Ligands, Novel Therapies. Korach, K.S. and Wintermantel, T. (eds.). Ernst Schering Foundation Symposium Proceedings. Springer-Verlag Berlin Heidelberg. Vol. 1, 25-44.

Zhang, S.-J., Steijaert, M.N., Lau, D., Schütz, G., Delucinge-Vivier, C., Descombes, P., and Bading, H. (2007). Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death. Neuron 53, 549-562.