Glycosphingolipids in the central nervous system – key players in obesity, type-2 diabetes and Alzheimer’s disease
Department of Cellular and Molecular Pathology (G130)
Deutsches Krebsforschungszentrum (DKFZ) Heidelberg
Im Neuenheimer Feld 280
We investigate the role of membrane lipids in the etiology and progression of obesity, type-2 diabetes, and neurodegenerative diseases such as Alzheimer's disease. We are specifically interested in gangliosides, a subclass of glycosphingolipids that are particularly highly expressed in cells of the nervous system.
We have detected that gangliosides regulate neuronal leptin and insulin receptor function in the hypothalamus. Currently, we are studying how gangliosides in neurons, astrocytes, and microglia affect neuroinflammation, which is observed in severe cases of obesity and which often precedes the onset of sporadic Alzheimer's disease.
Moreover, we investigate connections between brain insulin resistance and neurodegeneration. We have recently shown that gangliosides facilitate insulin receptor removal from the neuronal surface in models of Alzheimer's disease.
In summary, we aim to clarify if obesity, diabetes, and Alzheimer’s disease may be regarded, prevented, and treated as “diseases of central nervous membrane lipids”.
Structure of the Group
|Group Leader:||Viola Nordström|
|PhD Student:||Vanessa Dieterle|
|Undergraduate Student:||Klara Rehder|