Publications

Search for Niesler, B. publications on pubmedlogo

 

Selected publications:

ORIGINAL ARTICLES

Niesler B, Weiss B, Fischer C, Nöthen MM, ,Propping P, Bondy B Rietschel M, Maier W, Albus M, Franzek E, Rappold GA (2001).
Serotonin Receptor Gene HTR3A variants in schizophrenic and bipolar affective patients.
Pharmacogenetics 11: 21-27.

Niesler B, Flohr T, Nöthen MM, Fischer C, Rietschel M, Franzek E, Albus M, Propping P, Rappold GA (2001).
Association between the 5’UTR variant C178T of the Serotonin Receptor Gene HTR3A and bipolar affective disorder.
Pharmacogenetics 11: 471-5.

Niesler B, Frank B, Kapeller J, Rappold GA (2003).
Cloning, Physical Mapping and Expression Analysis of the human Serotonin Receptor-like Genes HTR3C, HTR3D and HTR3E.
Gene 310:101-111.

Frank B, Niesler B, Nöthen MM, Rietschel M, Franzek E, Albus M, Propping P, Rappold GA (2004).
Serotonin Receptor Gene HTR3B variants in schizophrenic and bipolar affective patients.
Am J Med Genet Neuropsychiatric Genetics 131B(1):1-5.

Niesler B, Walstab J, Combrink S, Moeller D, Kapeller J, Rietdorf J, Göthert M, Bönisch H, Rappold G,  Brüss M.
Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D and 5-HT3E (2007).
Mol Pharmacol 72(1):8-17. (IF 4,6)

Walstab J, Hammer C, Bönisch H, Rappold G, Niesler B (2008).
Natural variants in the HTR3B gene significantly alter properties of the human heteromeric 5-HT3AB receptor,
Pharmacogenet Genomics, Sep; 18(9):793-802.

Kapeller J, Houghton LA, Mönnikes H, Walstab J, Möller D, Bönisch H, Burwinkel B, Autschbach F, Funke B, Lasitschka F, Gassler N, Fischer C, Whorwell PJ, Atkinson W, Fell C,Büchner KJ, Schmidtmann M, van der Voort I, Wisser AS, Berg T, Rappold G, Niesler B (2008).
First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor type 3E gene with diarrhea predominant irritable bowel syndrome,
Hum Mol Genet, Oct 1;17(19):2967-77. Epub 2008 Jul 9.

Hammer C, Kapeller J, Endele M, Fischer C, Hebebrand J, Hinney A, Friedel S, Gratacòs M, Estivill X, Fichter M, Fernández-Aranda F, Ehrlich S, Rappold G, Niesler B (2009).
Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders,
Pharmacogenet Genomics, Sep 8. [Epub ahead of print], Oct;19(10):790-9.

Walstab J, Hammer C, Lasitschka F, Connolly CN, Rappold G, Brüss M, Bönisch H, Niesler B (2010).
RIC-3 Exclusively Enhances the Surface Expression of Human Homomeric 5-Hydroxytryptamine Type 3A (5-HT(3)A) Receptors Despite Direct Interactions with 5-HT3A, -C, -D, and -E Subunits,
Journal of Biological Chemistry, 2010 Aug 27;285(35):26956-65. Epub 2010 Jun 3.

Kapeller J, Moeller D, Liu MT, Lasitschka F, Autschbach F, Hovius R, Rappold G, Brüss M, Gershon MD, Niesler B (2011).
5-HT receptor diversity in the human colon: expression of novel 5-HT3 receptor subunits 5-HT3C, 5-HT3D and 5-HT3E.
Journal of Comparative Neurology, 2011 Feb 15;519(3):420-32.

Kilpatrick L, Labus JS, Coveleskie K, Hammer C, Rappold G, Tillisch K, Bueller JA, Suyenobu B, Jarcho M, McRoberts JA, Niesler B*& Mayer EA* (2011).
The HTR3A Polymorphism c. -42C>T Is Associated With Amygdala Responsiveness in Patients With Irritable Bowel Syndrome,
Gastroenterology, 2011 Mar 17. [Epub ahead of print]. 140(7): p. 1943-51 *joined senior authorship

Beyer T, Danilchik M, Thumberger T, Vick P, Bogusch S, Andre P, Ulmer B, Walentek P, Niesler B, Blum M, Schweickert A (2012).
Serotonin signaling is required for Wnt-dependent GRP specification and leftward flow in Xenopus,
Current Biology, Jan 10;22(1):33-9. Epub 2011 Dec 15.

Hammer C, Cichon S, Mühleisen TW, Haenisch B, Degenhardt F, Breuer R, Witt S, Strohmaier J, Oruc L, Rivas F, Babadjanova G, Grigoroiu-Serbanescu M, Hauser J, Röth R, Rappold G, Rietschel M,  Nöthen MN, Niesler B (2012).
Replication of functional serotonin receptor type 3A and B variants in bipolar affective disorder: a European multicenter study,
Transl Psychiatry 2: e103; doi:10.1038/tp.2012.30.

Walstab J, Krüger D, Stark T, Hofmann T, Demir IE, Ceyhan GO, Feistel B, Schemann M, Niesler B (2013).
Ginger and its pungent constituents non-competitively antagonise human recombinant and native 5-HT3 receptors of enteric neurons,
Neurogastroenterol Motil. 2013 Mar 12. doi: 10.1111/nmo.12107. [Epub ahead of print] >> Research Highlight Nature Gastroenterology and Hepatology March 2013,  doi:10.1038/nrgastro.2013.54.

Hammer C, Degenhardt F, Priebe L, Stütz A, Heilmann S, Waszak S, Schlattl A, Mangold E, Hoffmann P, MooDS Consortium, Nöthen MM, Rietschel M, Rappold G, Korbel J, Cichon S, Niesler B (2014).
A common microdeletion affecting a hippocampus- and amygdala-specific isoform of tryptophan hydroxylase 2 is not associated with affective disorders,
Bipolar Disorders 2014 Apr 23. doi: 10.1111/bdi.12207. [Epub ahead of print]

The Concise Guide to PHARMACOLOGY 2013/14: overview.
Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg

Walstab J, Wohlfarth C, Hovius R, Schmitteckert S, Röth R, Lasitschka F, Wink M, Bönisch H, Niesler B.
Natural compounds boldine and menthol are antagonists of human 5-HT3 receptors: implications for treating gastrointestinal disorders.
Neurogastroenterology and Motility. 2014 Jun;26(6):810-820. doi: 10.1111/nmo.12334. Epub 2014 Apr 8.

Almouzni G, Altucci L, Amati B, Ashley N, Baulcombe D, Beaujean N, Bock C, Bongcam-Rudloff E, Bousquet J, Braun S, de Paillerets BB, Bussemakers M, Clarke L, Conesa A, Estivill X, Fazeli A, Grgurevi NA, Gut I, Heijmans BT, Hermouet S, Houwing Duistermaat J, Iacobucci I, Ila J, Kandimalla R, Krauss-Etschmann S, Lasko P, Lehmann S, Lindroth A, Majdi G, Marcotte E, Martinelli G, Martinet N, Meyer E, Miceli C, Mills K, Moreno-Villanueva M, Morvan G, Nickel D, Niesler B, Nowacki M, Nowak J, Ossowski S, Pelizzola M, Pochet R, Poto Nik U, Radwanska M, Raes J, Rattray M, Robinson MD, Roelen B, Sauer S, Schinzer D, Slagboom E, Spector T, Stunnenberg HG, Tiligada E, Torres-Padilla ME, Tsonaka R, Van Soom A, Vidakovi M, Widschwendter M. (2014)
Relationship between genome and epigenome - challenges and requirements for future research.
BMC Genomics. 2014 Jun 18;15(1):487. [Epub ahead of print]

Ek WE, Ripke S, Rivera NV, Zucchelli M, Niesler B, Schmidt PT, Pedersen NL,Magnusson P, Talley NJ, Holliday L, Houghton LA, Gazouli M, Karamanolis G, Rappold G, Burwinkel B, Surowy H, Rafter J, Assadi G, Li L, Papadaki E, Gambaccini D, Marchi S, Colucci R Barbaro R, Karling P, Walter S, Ohlsson B, Tornblom H, Bresso F, Andreasson A, Dlugosz A, Simren M, Agreus L, Lindberg G, Boeckxstaens G, Bellini M, Stanghellini V, Barbara G, Daly MJ, Camilleri M, Wouters MM, D'Amato M (2014).
Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multi-national case-control cohorts.
Gut. 2015 Nov;64(11):1774-82. doi: 10.1136/gutjnl-2014-307997. Epub 2014 Sep 23.

Czogalla B, Schmitteckert S, Houghton LA, Sayuk GS, Olivo-Diaz A, Camilleri M, Spiller R, Wouters MM, Boeckxstaens G, Lorenzo Bermejo J, Niesler B (2015).
A meta-analysis of immunogenetic case-control association studies in Irritable Bowel Syndrome.
Neurogastroenterology and Motility 2015 Mar 30. doi: 10.1111/nmo.12548. [Epub ahead of print].

Orand A, Gupta A, Shih W, Presson AP, Hammer C, Niesler B, Heendeniya N, Mayer EA, Chang L (2015).
Catecholaminergic Gene Polymorphisms are Associated with GI Symptoms and Morphological Brain Changes in Irritable Bowel Syndrome.
PLoS One. 2015 Aug 19;10(8):e0135910. doi: 10.1371/journal.pone.0135910. eCollection 2015

Rosenbaum C, Schick MA, Wollborn J, Heider A, Scholz CJ, Cecil A, Niesler B, Hirrlinger J, Walles H, Metzger M. (2016)
Activation of enteric glia during acute systemic inflammation in vitro and in vivo.
PLoS One. 2016 Mar 10;11(3):e0151335. doi: 10.1371/journal.pone.0151335. eCollection 2016.

Boeckxstaens GE, Drug V, Dumitrascu D, Farmer A, Hammer J, Hausken T, Niesler B, Pohl D, Pojskic L, Polster A, Simren M, Stengel M, Van Oudenhove L, Vassallo M, Wensaas K-A, Aziz Q & Houghton LA and COST Action BM1106 GENIEUR members (www.GENIEUR.eu) (2016).
Phenotyping of subjects for large scale studies on patients with IBS.
Neurogastroenterology and Motility, 2016 Aug;28(8):1134-47. doi: 10.1111/nmo.12886. Epub 2016 Jun 19.

Celli J, Rappold GA, Niesler B. (2017).
The first Human Serotonin Type 3 Receptor Gene (HTR3A-E) Allelic Variant Database Human Mutation, 2017 Feb;38(2):137-147. doi: 10.1002/humu.23136. Epub 2016 Nov 9. (IF 5,144)

Martínez C, Rodiño-Janeiro BK, Lobo B, Stanifer ML, Klaus B, Granzow M, González-Castro AM, Salvo-Romero E, Alonso-Cotoner C, Pigrau M, Frias C, Roeth R, Rappold G, Huber W, Gonzalez- Silos R, Lorenzo J, de Torres I, Azpiroz F, Boulant S, Vicario M*, Niesler B*& Santos J*(2017)
miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in irritable bowel syndrome with diarrhoea.
Gut, 2017 Jan 12. pii: gutjnl-2016-311477. doi: 10.1136/gutjnl-2016-311477. [Epub ahead of print],*joint senior authorship, >>> highlighted as Commentary in Gut 2017 (IF 16,658)

Berens S, Kraus F, Gauss A, Tesarz J, Herzog W, Niesler B, Stroe-Kunold E, Schaefert R. (2017).
A specialty clinic for functional gastrointestinal disorders in tertiary care: Concept and patient population.
Clinical Gastroenterology and Hepatology 2017 Mar 11. pii: S1542-3565(17)30284-7. doi: 10.1016/j.cgh.2017.02.039. [Epub ahead of print] (IF 7,680)

Wohlfarth C#, Schmitteckert S#,  Härtle JD, Houghton LA, Dweep H, Fortea M, Assadi G, Braun A, Mederer T, Pöhner S, Becker PB, Fischer C, Granzow M, Mönnikes H, Mayer EA, Sayuk G, Boeckxstaens G, Wouters MM,  Simrén M,  Lindberg G, Ohlsson B, Schmidt PT, Dlugosz A , Agreus L,   Andreasson A,  D’Amato M, Burwinkel B, Lorenzo J, Röth R, Lasitschka F, Vicario M, Metzger M,, Santos J, Rappold G, *Martinez C¸ *Niesler B
miRNA-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome.
SciRep, in revision, #joint first authorship, *joint senior authorship (IF 5,228)

Thomann AK, Reindl W, Wüstenberg T, Kmuche D, Ebert MP, Szabo K, Wolf RC, Hirjak D, Niesler B, Griebe M, Thomann PA (2019). Aberrant brain structural large-scale connectome in Crohn’s disease, Neurogastroenterology and Motility, 2019 Jun;31(6):e13593. doi: 10.1111/nmo.13593. Epub 2019 Apr 14. (IF 3,803)

Gunn D, Garsed K, Lam C, Singh G, Lingaya M, Wahl V, Niesler B, Henry A, Hall I, Whorwell P, Spiller R (2019). Abnormalities of mucosal serotonin metabolism in IBS with diarrhoea predict responsiveness to Ondansetron, a 5-HT3 receptor antagonist, Alimentary Pharmacology and Therapeutics, 019 Sep;50(5):538-546. doi: 10.1111/apt.15420. Epub 2019 Jul 24. (IF 7,357)

Schmitteckert S, Mederer T, Roeth R, Guenther P, Holland-Cunz S, Metzger M, Samstag Y, Schröder-Braunstein J, Wabnitz G, Kurzhals S, Scheuerer J, Beretta CA, Lasitschka F, Rappold GA, Romero P, Niesler B (2019). Postnatal human enteric neurospheres show a remarkable molecular complexity, Neurogastroenterology and Motility, 2019 Oct;31(10):e13674. doi: 10.1111/nmo.13674. Epub 2019 Jul 18. (IF 3,803)

Fröhlich H, Kollmeyer ML, Linz V, Stuhlinger M, Groneberg D, Reigl A, Zizer E, Friebe A, Niesler B*, Rappold, GA*(2019). Gastrointestinal dysfunction in autism: altered motility and achalasia in Foxp1+/- mice, Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22237-22245. doi: 10.1073/pnas.1911429116. Epub 2019 Oct 14. *equal contribution (IF 9,58)

Sonner JK, Keil M, Falk-Paulsen M, Mishra N, Rehman A, Kramer M, Deumelandt K, Röwe J, Sanghvi K, Wolf L, von Landenberg A, Wolff H, Bharti R, Oezen I, Lanz TV, Wanke F, Tang Y, Brandao I, Mohapatra SR, Epping L, Grill A, Röth R, Niesler B, Meuth SG, Opitz CA, Okun JG, Reinhardt C, Kurschus FC, Wick W, Bode HB, Rosenstiel P, Platten M. (2019). Dietary tryptophan links encephalogenicity of autoreactive T cells with gut 1 microbial ecology, Nature Communications, 2019 Oct 25;10(1):4877. doi: 10.1038/s41467-019-12776-4. (IF 11,88)

Martinez C*, Lasitschka F*, Thöni C, Wohlfarth C, Granzow M, Röth R, Rappold GA, Dizdar V, Hausken T, Langeland N, Hanevik K, Niesler B (2020). Comparative expression profiling in the intestine of patients with Giardia-induced post-infectious functional gastrointestinal disorders, *equal contribution, Neurogastroenterology and Motility, 2020;00: e13868. https://doi.org/10.1111/nmo.13868 (IF 3,803)

Mederer T*, Schmitteckert S*, Volz J, Martinez C, Roeth R, Thumberger T, Eckstein V, Scheuerer J, Thöni C, Lasitschka F, Carstensen L, Günther P, Holland-Cunz S, Hofstra R, Brosens E., Rosenfeld J.A., Schaaf C.P., Schriemer D., Ceccherini I., Rusmini M., Tilghman J., Luzón-Toro B, Torroglosa A, Borrego S, Szeman Tang C, Garcia-Barcelo M, Tam P, Paramasivam N, Bewerunge-Hudler M, de la Torre C, Gretz N, Rappold GA, Romero P#, Niesler B# (2020). A complementary study approach unravels novel players in the pathoetiology of Hirschsprung disease, PLOS Genetics 2020 Nov 5;16(11):e1009106. doi: 10.1371/journal.pgen.1009106. eCollection 2020 Nov.PLoS Genet. 2020. PMID: 33151932 (*,# equal contribution)  (IF 5,03)

Konturek TJ, Martinez C, Niesler B, van der Voort I, Mönnikes H, Stengel A, Goebel-Stengel (2021). The Role of Brain-derived Neurotrophic Factor in Irritable Bowel Syndrome, Frontiers in Psychiatry, section Psychosomatic Medicine, 2021 Jan 14;11:531385. doi: 10.3389/fpsyt.2020.531385. eCollection 2020 (IF 3,532)

Cossais F, Schaeffer E, Heinzel S, Zimmermann J, Niesler B, Röth R, Rappold G, Scharf A, Zorenkov D, Lange C, Barrensche M, Margraf NG, Ellrichmann M, Berg D, Böttner M, Wedel T.J (2021). Expression Profiling of Rectal Biopsies Suggests Altered Enteric Neuropathological Traits in Parkinson's Disease Patients, Parkinsons Dis. 2021;11(1):171-176. doi: 10.3233/JPD-202258.PMID: 33337386 (IF 5,178)

Gries M, Christmann A, Schulte S, Weyland M, Rommel S, Martin M, Baller M, Röth R, Schmitteckert S, Unger M, Grundmann D, Liu Y, Sommer F, Mühlhaus T, Schroda M, Timmermans JP, Pintelon I, Lashuel H, Rappold GA, Britschgi M, Laschke M, Niesler B, Schäfer KH (2021). Functional and molecular early enteric biomarkers for Parkinson’s disease in mice and men, Molecular Neurodegeneration, in press (IF 9,599)

REVIEWS

Walstab J, Rappold G, Niesler B (2010)
5-HT3 receptors: role in disease and target of drugs.
Pharmacology and Therapeutics, 2010 Oct;128(1):146-69. Epub 2010 Jul 16.2010 Jul 16. [Epub ahead of print].

Niesler B (2011)
5-HT3 Receptors: Potential of individual isoforms for personalised therapy.
Current Opinion in Pharmacology, 2011 Feb;11(1):81-6. Epub 2011 Feb 21.

Gazouli M, Wouters MM, Kapur-Pojskić L, Bengtson MB, Friedman E, Nikčević G, Demetriou C, Mulak A, Santos J, Niesler B (2016).
Lessons learned: Resolving the enigma of genetic factors in Irritable Bowel Syndrome.
Nature Reviews Gastroenterology & Hepatology 2016 Feb;13(2):77-87. doi: 10.1038/nrgastro.2015.206, Published online, 04 January 2016.

Enck P, Aziz Q, Barbara G, Farmer A, Fukudo S, Mayer E, Niesler B, Quigley E, Rajilic-Stojanovic M, Schemann M, Schwille-Kiuntke J, Simren M, Zipfel S, Spiller R (2016).
Irritable Bowel Syndrome.
Nature Reviews Disease Primers, Nature Reviews Disease Primers, 2, Article number: 16015 (2016) doi:10.1038/nrdp.2016.15.

Schmitteckert S, Mederer T, Niesler B (2016).
Genetik der Darm-Hirn-Achse am Beispiel des Reizdarmsyndroms.
NeuroLogisch Focus: Neurogastroenterologie, neuro 02|2016 08.07.2016.

Niesler B & Rappold GA (2020). Emerging evidence for gene mutations driving both brain and gut dysfunction in autism spectrum disorder, Molecular Psychiatry, 2020 May 27. doi: 10.1038/s41380-020-0778-5. Online ahead of print. (IF 11,973)

Niesler B, Kuerten S, Demir IE, Schäfer KH (2020). Disorders of the enteric nervous system - a holistic view, Nature Reviews Gastroenterology & Hepatology,  2021 Jan 29. doi: 10.1038/s41575-020-00385-2. Online ahead of print. (IF 23,570)

Editor: Email
Latest Revision: 2021-04-07
zum Seitenanfang/up