Publications
Peer-reviewed publications
Search for Niehrs, C. Publications on 
(since 2000)
1. Dosch, R. and Niehrs, C. (2000). Requirement of anti-dorsalizing morphogenetic protein in organizer patterning. Mech. Dev. 90, 195-203.
2. Pollet, N., Schmidt, H.A., Gawantka, V., Vingron, M. and Niehrs, C. (2000). Axeldb: A Xenopus laevis database focussing on gene expression. Nucleic Acids Res. 28,139-140.
3. Roessler, E., Du, Y., Glinka, A., Dutra, A., Niehrs, C., and Muenke, M. (2000). The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly. Cytogenet Cell Genet 89, 220-224.
3. Otto, C., Schütz, G., Niehrs, C. and Glinka, A. (2000). Dissecting GHRH- and PACAP-mediated signalling in Xenopus. Mech. Dev. 94, 111-116.
4. Kiecker, C., Müller, F., Wu, W., Glinka, A., Strähle, U. and Niehrs, C. (2000). Phenotypic effects in Xenopus and zebrafish suggest that one-eyed-pinhed functions as antagonist of BMP signalling. Mech. Dev. 94, 37-46.
5. Kazanskaya, O., Glinka, A., and Niehrs, C. (2000). The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning. Development 127, 4981-4992.
6. Wu, W., Glinka, A., Delius, H. and Niehrs, C. (2000). Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/b-catenin signalling. Curr. Biol. 10, 1611-1614.
7. Chen, Y., Pollet, N., Niehrs, C. and Pieler, T. (2001). Increased XRALDH2 activity has a posteriorizing effect on the central nervous system of Xenopus embryos Mech. Dev. 101, 91-103.
8. Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A. and Niehrs, C. (2001). LDL receptor related protein 6 is a receptor for Dickkopf proteins. Nature 411, 321-325.
9. Lamar, E., Deblandre, G., Wettstein, D., Gawantka, V., Pollet, N., Niehrs, C., and Kintner, C. (2001). Nrarp is a novel intracellular component of the Notch signaling pathway. Genes Dev 15, 1885-99.
10. Mukhopadhyay, M., Shtrom, S., Rodriguez-Esteban, C., Chen, L., Tsuku, T., Gomer, L., Dorward, D. W., Glinka, A., Grinberg, A., Huang, S.-P., Niehrs, C., Izpisúa Belmonte, J.-C., and Westphal, H. (2001). Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Developmental Cell 1, 423-434.
11. Duncan, P. I., Pollet, N., Niehrs, C., and Nigg, E. A., (2001). Cloning and Characterization of Plx2 and Plx3, Two Additional Polo-like Kinases from Xenopus laevis. Exp Cell Res 270, 78-87.
12. Kiecker, C. and Niehrs, C. (2001). A morphogen gradient of Wnt/beta-catenin signaling regulates anteroposterior neural patterning in Xenopus. Development 128, 4189-4201.
13. Mao, B., Wu, W., Davidson, G, Marhold, J., Li, M., Mechler, B.M, Delius, H., Hoppe, D., Stannek, P., Walter, C., Glinka, A. and Niehrs, C. (2002). Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 417, 664-667.
14. Davidson, G., Mao, B., Del Barco, I. and Niehrs, C. (2002). Kremen proteins interact with Dickkopf1 to regulate anterior-posterior CNS patterning. Development 129, 5587-5596.
15. Li, Y., Fenger, U., Niehrs, C. and Pollet, N. (2003). Cyclic expression of esr9 and esr10 genes in Xenopus presomitic mesoderm. Differentiation 71, 83-89.
16. Mao B, Niehrs C. (2003). Kremen2 modulates Dickkopf2 activity during Wnt/lRP6 signaling. Gene 302, 179-83.
17. del Barco Barrantes I., Davidson G., Gröne H.J., Westphal H., Niehrs C. (2003). Dkk1 and noggin cooperate in mammalian head induction. Genes Dev. 15, 2239-2244.
18. Pollet N, Delius H, Niehrs C. (2003). In situ analysis of gene expression in Xenopus embryos. C R Biol. 326(10-11), 1011-7.
19. Böttcher R., Pollet N., Delius H., Niehrs C. (2004). The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling. Nature Cell Biology 6(1), 38-44.
20. Konig R, Baldessari D, Pollet N, Niehrs C, Eils R. (2004). Reliability of gene expression ratios for cDNA microarrays in multiconditional experiments with a reference design. Nucleic Acids Res. 32(3):e29.
21. Karaulanov E, Knochel W, Niehrs C. (2004). Transcriptional regulation of BMP4 synexpression in transgenic Xenopus. EMBO J. 23(4), 844-56.
22. Hansis, C., Barreto, G., Maltry, N., Niehrs, C. (2004). Nuclear reprogramming of human somatic cells by xenopus egg extract requires BRG1. Curr Biol. 14(16), 1475-80.
23. Kazanskaya O., Glinka A., Del Barco Barrantes I., Stannek P., Niehrs C., Wu W. (2004). R-Spondin2 Is a Secreted Activator of Wnt/beta-Catenin Signaling and Is Required for Xenopus Myogenesis. Dev Cell. 7(4), 525-34
24. Baldessari D, Shin Y, Krebs O, Konig R, Koide T, Vinayagam A, Fenger U, Mochii M, Terasaka C, Kitayama A, Peiffer D, Ueno N, Eils R, Cho KW, Niehrs C. (2005). Global gene expression profiling and cluster analysis in Xenopus laevis. Mech Dev. 122(3), 441-75.
25. Pollet N, Muncke N, Verbeek B, Li Y, Fenger U, Delius H, Niehrs C. (2005). An atlas of differential gene expression during early Xenopus embryogenesis. Mech Dev. 122(3), 365-439.
26. Davidson, G., Wu, W., Shen, J., Bilic, J., Fenger, U., Stannek, P., Glinka, A., Niehrs, C. (2005). Casein kinase 1 couples Wnt receptor activation to the cytoplasmic signal transduction. Nature 438(7069), 867-72.
27. Karaulanov, E., Böttcher, R.T. and Niehrs, C. (2006). A role for FLRT cell surface proteins in homotypic cell adhesion. EMBO Rep. 7(3), 283-90.
28. Guder, C., Nacak, T., Pinho, S., Hobmayer, E., Niehrs, C. Holstein, T. (2006). An Ancient Wnt-Dickkopf Antagonism in Hydra. Development 133(5), 901-11.
29. del Barco Barrantes, I. et al. (23 coauthors) and Niehrs, C. (2006). Generation and characterization of dickkopf3 mutant mice. Mol Cell Biol. 26(6), 2317-26.
30. Cruciat CM, Hassler C., Niehrs C. (2006). The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition. J Biol Chem. 281(18), 12986-93.
31. Mukhopadhyay, M., Gorivodsky, M., Shtrom, S., Grinberg, A., Niehrs, C., Morasso, M.I., Westphal, H. (2006). Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium. Development 133(11), 2149-54.
32. Morvan F., Boulukos K., Clement-Lacroix P., Roman Roman S., Suc-Royer I., Vayssiere B., Ammann P., Martin P., Pinho S., Pognonec P., Mollat P., Niehrs C., Baron R., Rawadi G. (2006). Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res. 21(6), 934-45.
33. Barreto G., Schafer A., Marhold J., Stach D., Swaminathan S.K., Handa V., Doderlein G., Maltry N., Wu W., Lyko F., Niehrs C. (2007). Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 445(7128), 671-5.
34. Caneparo L, Huang YL, Staudt N, Tada M, Ahrendt R, Kazanskaya O, Niehrs C, Houart C. (2007). Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/beta catenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek. Genes Dev. 21(4), 465-80.
35. Pinho S, Niehrs C. (2007). Dkk3 is required for TGF-beta signaling during Xenopus mesoderm induction. Differentiation. 2007 May 9; [Epub ahead of print]
36. Bilic J, Huang YL, Davidson G, Zimmermann T, Cruciat CM, Bienz M, Niehrs C. (2007). Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science 316(5831), 1619-22.
37. Ogata S, Morokuma J, Hayata T, Kolle G, Niehrs C, Ueno N, Cho KW. (2007). TGF-beta signaling-mediated morphogenesis: modulation of cell adhesion via cadherin endocytosis. Genes Dev. 21(14), 1817-31.
38. Carmona-Fontaine C, Acuna G, Ellwanger K, Niehrs C, Mayor R. (2007). Neural crests are actively precluded from the anterior neural fold by a novel inhibitory mechanism dependent on Dickkopf1 secreted by the prechordal mesoderm. Dev Biol. 309(2), 208-21.
Reviews
1. Niehrs, C. and Pollet, N. (2000). Synexpression groups in eukaryotes. Nature 402, 483-487.
2. Pollet, N., Schmidt, H.A., Gawantka, V., Vingron, M. and Niehrs, C. (2000). Axeldb: A Xenopus laevis database focussing on gene expression. Nucleic Acids Res. 28,139-140.
3. Niehrs, C. (2000). Amphibian organizer activity. in: Developmental Biology Protocols, Vol III (eds. R. S. Tuan and C. W. Lo), Humana Press, Totowa. pp. 179-183.
4. de Souza, F. and Niehrs, C. (2000). Anterior endoderm and head induction in early vertebrate embryos. Cell Tissue Res. 300, 207-217.
5. Niehrs, C., Dosch, R. and Onichtchouk, D. (2000). Embryonic patterning of Xenopus mesoderm by BMP-4. Proceedings of the E. Schering Research Foundation (eds. C. Nüsslein-Volhard and J. Kräztschmer) 29, 165-190.
6. Pollet, N., Gawantka, V., Delius, H., and Niehrs, C. (2000). Large scale gene expression screening identifies molecular pathways and predicts gene function. In Genomics and Proteomics. S. Suhai, eds. (New York: Kluwer Academic/Plenum Publishers), pp. 27-36.
7. Pollet, N., Schmidt, H.A., Gawantka, V., Niehrs, C., and Vingron, M. (2000). In silico analysis of gene expression patterns during early development of Xenopus laevis. Pac Symp Biocomput 443-454.
8. Kiecker, C. and Niehrs, C. (2001). The role of prechordal mesendoderm in neural patterning. Curr Opin Neurobiol, 11, 27-33.
9. Niehrs, C. (2001) MEDAL REVIEW: The Spemann organizer and embryonic head induction. Embo J, 20, 631-637.
10. Pollet, N. and Niehrs, C. (2001). Expression profiling by systematic high-throughput in situ hybridization to whole-mount embryos. Methods Mol Biol 175, 309-21.
11. Niehrs, C. (2001). Dickkopf-1, a secreted protein involved in head induction; Human Frontier Science Program Workshop X (Ang, S.-L et al. editors) p. 128-132.
12. Niehrs, C. (2001). Solving a sticky problem. Nature, 413, 787-788.
13. Niehrs, C., Meinhardt H. (2002). Modular feedback. Nature. 41,35-36.
14. Niehrs, C. (2003). Developmental biology: a tale of tails. Nature. 24, 375-376.
15. Niehrs, C. (2004). Norrin and frizzled; a new vein for the eye. Dev Cell. 6(4):453-4.
16. Niehrs, C. (2004). Regionally specific induction by the Spemann-Mangold organizer. Nat Rev Genet. 5(6):425-34. 57.
17. Böttcher R., Niehrs, C. (2005). Fibroblast Growth Factor Signalling during early vertebrate development. Endocr Rev. 26(1):63-77.
18. Niehrs, C. (2005). Axis formation: redundancy rules. Curr Biol. 2005 May 24;15(10):R391-3.
Articles in books
Article in a book: King, S.M. (2003). Dynein motors: Structure, mechanochemistry and regulation. In Molecular Motors, M. Schliwa, ed. (Weinheim, Germany: Wiley-VCH Verlag GmbH), pp. 45-78.
Niehrs, C. (2000). Amphibian organizer activity.In Developmental Biology Protocols, Vol III, eds. R.S. Tuan and C.W. Lo (Humana Press, Totowa) pp. 179-183.
Pollet, N., Gawantka, V., Delius, H., and Niehrs, C. (2000). Large scale gene expression screening identifies molecular pathways and predicts gene function. In Genomics and Proteomics. S. Suhai, eds.
(New York: Kluwer Academic/Plenum Publishers), pp. 27-36.
Niehrs, C. (2004). Synexpression groups: Genetic modules and Embryonic Development. In Modularity in Development and Evolution G. Schlosser and G.P. Wagner, eds.
(Chicago Press) pp 187-201.
