Publications

Peer-reviewed publications

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(since 2003)

O'Sullivan, N.C., Jahn, T.R., Reid, E., and O'Kane, C.J. (2012). Reticulon-like-1, the Drosophila orthologue of the Hereditary Spastic Paraplegia gene reticulon 2, is required for organization of endoplasmic reticulum and of distal motor axons. Hum Mol Genet. 21, 3356-65.

Speretta, E., Jahn, T.R., Tartaglia, G.G., Favrin, G., Barros, T.P., Imarisio, S., Lomas, D.A., Luheshi, L.M., Crowther, D.C., and Dobson, C.M. (2012). Expression in Drosophila of Tandem Amyloid-beta Peptides Provides Insights into Links between Aggregation and Neurotoxicity. J Biol Chem 287, 20748-20754.

Thackray, A.M., Muhammad, F., Zhang, C., Di, Y., Jahn, T.R., Landgraf, M., Crowther, D.C., Evers, J.F., and Bujdoso, R. (2012). Ovine PrP transgenic Drosophila show reduced locomotor activity and decreased survival. Biochem J 444, 487-495.

Jahn, T.R., Kohlhoff, K.J., Scott, M., Tartaglia, G.G., Lomas, D.A., Dobson, C.M., Vendruscolo, M., and Crowther, D.C. (2011). Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease. J Neurosci Methods 197, 186-189.

Kohlhoff, K.J., Jahn, T.R., Lomas, D.A., Dobson, C.M., Crowther, D.C., and Vendruscolo, M. (2011). The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster. Integr Biol (Camb) 3, 755-760.

Jahn, T.R., Makin, O.S., Morris, K.L., Marshall, K.E., Tian, P., Sikorski, P., and Serpell, L.C. (2010). The common architecture of cross-beta amyloid. J Mol Biol 395, 717-727.

Hodkinson, J.P., Jahn, T.R., Radford, S.E., and Ashcroft, A.E. (2009). HDX-ESI-MS reveals enhanced conformational dynamics of the amyloidogenic protein beta-2-microglobulin upon release from the MHC-1. J Am Soc Mass Spectrom 20, 278-286.

White, H.E., Hodgkinson, J.L., Jahn, T.R., Cohen-Krausz, S., Gosal, W.S., Muller, S., Orlova, E.V., Radford, S.E., and Saibil, H.R. (2009). Globular tetramers of beta-2-microglobulin assemble into elaborate amyloid fibrils. J Mol Biol 389, 48-57.

Jahn, T.R., Tennent, G.A., and Radford, S.E. (2008). A common beta-sheet architecture underlies in vitro and in vivo beta-2-microglobulin amyloid fibrils. J Biol Chem 283, 17279-17286.

Jahn, T.R., Parker, M.J., Homans, S.W., and Radford, S.E. (2006). Amyloid formation under physiological conditions proceeds via a native-like folding intermediate. Nature Struct Mol Biol 13, 195-201.

Smith, A.M., Jahn, T.R., Ashcroft, A.E., and Radford, S.E. (2006). Direct observation of oligomeric species formed in the early stages of amyloid fibril formation using electrospray ionisation mass spectrometry. J Mol Biol 364, 9-19.

Myers, S.L., Jones, S., Jahn, T.R., Morten, I.J., Tennent, G.A., Hewitt, E.W., and Radford, S.E. (2006). A systematic study of the effect of physiological factors on beta-2-microglobulin amyloid formation at neutral pH. Biochemistry 45, 2311-2321.

Reviews

Jahn, T.R., Malzer, E., Roote, J., Vishnivetskaya, A., Imarisio, S., Giannakou, M., Panser, K., Marciniak, S., and Crowther, D.C. (2011). Modeling serpin conformational diseases in Drosophila melanogaster. Methods Enzymol 499, 227-258.

Jahn, T.R., and Radford, S.E. (2008). Folding versus aggregation: polypeptide conformations on competing pathways. Arch Biochem Biophys 469, 100-117.

Jahn, T.R., and Radford, S.E. (2005). The Yin and Yang of protein folding. FEBS J 272, 5962-5970.