Identification of cis-regulatory grammar controlling embryonic development in vertebrates

ettwiller.jpgLaurence Ettwiller

Department of Developmental Biology
COS
INF 230
69120 Heidelberg
Germany

Phone:  +49-6221-54-6495
Fax:  +49-6221-54-5639
Email:  Laurence.Ettwiller@cos.uni-heidelberg.de
Website:  http://www.cos.uni-heidelberg.de/index.php/l.ettwiller?l=_e

 

Research Summary:

Our understanding of vertebrate brain development is limited by our ability to identify the precise mechanisms that lead a progenitor cell to commit to specific cell fates. The players are complex networks of trans-acting factors that act on cis-regulatory sequences to activate or repress given sets of genes.

The main interest of the research carried on in the lab revolves around deciphering the logic governing transcription regulation during vertebrate development. The general strategy employed consists of tightly combining computational methodologies and experimental validations in the model fish, Oryzias latipes (medaka).

The Medaka fish is an ideal system to study regulation of transcription in vertebrate. Its genome has been fully sequenced and the species lies in an ideal evolutionary distance from other sequenced fishes for the analysis of non-coding elements. Number of genetic tools have been developed in medaka including enhancer assays that we use in the lab.

Structure of the Group:

Group Leader Laurence Ettwiller
   
Postdoctoral fellows Dirk Dolle, Michael Eichenlaub, Xiaodong Ma
Undergraduates Thomas Auer, Franziska Gruhl

 

Editor: A. Summerfield
Latest Revision: 2013-03-05
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