Publications
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Peer-reviewed publications
Lagrèze WA, Küchlin S, Ihorst G, Grotejohann B, Beisse F, Volkmann M, Heinrich SP, Albrecht P, Ungewiss J, Wörner M, Hug MJ, Wolf S, Diem R; TONE study group (2021)
Safety and efficacy of erythropoietin for the treatment of patients with optic neuritis (TONE): a randomised, double-blind, multicentre, placebo-controlled study.
Lancet Neurol 12:991-1000
Richter F, Williams SK, John K, Huber C, Vaslin C, Zanker H, Fairless R, Pichi K, Marhenke S, Vogel A, Dhaen MA, Herrmann S, Herrmann A, Pfizenmaier K, Bantel H, Diem R, Kontermann RE, Fischer R (2021)
The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation.
Front Immunol 12:705485
Fairless R, Williams SK, Katiyar R, Maxeiner S, Schmitz F, Diem R (2020)
ERG Responses in Mice with Deletion of the Synaptic Ribbon Component RIBEYE
Invest Ophthalmol Vis Sci 61:37
Schlüter A, Aksan B, Diem R, Fairless R, Mauceri D (2020)
VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury.
Mol Ther Methods Clin Dev 17:281-299
Bojcevski J, Stojic A, Hoffmann DB, Williams SK, Müller A, Diem R, Fairless R (2020)
Influence of retinal NMDA receptor activity during autoimmune optic neuritis.
J Neurochem 153:693-709
Brugnara G, Isensee F, Neuberger U, Bonekamp D, Petersen J, Diem R, Wildemann B, Heiland S, Wick W, Bendszus M, Maier-Hein K, Kickingereder P (2020)
Automated volumetric assessment with artificial neural networks might enable a more accurate assessment of disease burden in patients with multiple sclerosis.
Eur Radiol 30:2356-2364
Fischer R, Padutsch T, Bracchi-Ricard V, Murphy KL, Martinez GF, Delguercio N, Elmer N, Sendetski M, Diem R, Eisel ULM, Smeyne RJ, Kontermann RE, Pfizenmaier K, Bethea JR. (2019)
Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis.
Brain Behav Immun 81:247-259
Stojic A, Bojcevski J, Williams SK, Bas-Orth C, Nessler S, Linington C, Diem R, Fairless R (2019)
Preclinical stress originates in the rat optic nerve head during development of autoimmune optic neuritis.
Glia 67:512-524
Ungerer MN, Diem R, Wrede A, Huang K, Hähnel S, Wick W, Winkler F (2018)
Steroid-Responsive Relapsing-Remitting Neutrophilic Encephalitis: A Case Report.
J Neuropathol Exp Neurol 77:993-996
Dembla M, Kesharwani A, Natarajan S, Fecher-Trost C, Fairless R, Williams SK, Flockerzi V, Diem R, Schwarz K, Schmitz F (2018)
Early auto-immune targeting of photoreceptor ribbon synapses in mouse models of multiple sclerosis.
EMBO Mol Med 10:pii:e8926
Williams SK, Fairless R, Maier O, Liermann PC, Pichi K, Fischer R, Eisel ULM, Kontermann R, Herrmann A, Weksler B, Romero N, Couraud PO, Pfizenmaier K, Diem R (2018)
Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis.
Sci Rep 8:13628
Mayer C, Bruehl C, Salt EL, Diem R, Draguhn A, Fairless R (2018)
Selective Vulnerability of αOFF Retinal Ganglion Cells during Onset of Autoimmune Optic Neuritis.
Neuroscience 393:258-272
Karimian-Jazi K, Wildemann B, Diem R, Schwarz D, Hielscher T, Wick W, Bendszus M, Breckwoldt MO (2018)
Gd contrast administration is dispensable in patients with MS without new T2 lesions on follow-up MRI.
Neurol Neuroimmunol Neuroinflamm 5:e480
Stojic A, Bojcevski J, Williams SK, Diem R, Fairless R.
Early Nodal and Paranodal Disruption in Autoimmune Optic Neuritis.
J Neuropathol Exp Neurol 77:361-373
Jende JME, Hauck GH, Diem R, Weiler M, Heiland S, Wildemann B, Korporal-Kuhnke M, Wick W, Hayes JM, Pfaff J, Pham M, Bendszus M, Kollmer J (2017)
Peripheral nerve involvement in multiple sclerosis: Demonstration by magnetic resonance neurography.
Ann Neurol 82:676-685
Wildemann B, Jarius S, Schwarz A, Diem R, Viehöver A, Hähnel S, Reindl M, Korporal-Kuhnke M (2017)
Failure of alemtuzumab therapy to control MOG encephalomyelitis.
Neurology 89:207-209
Lanz TV, Williams SK, Stojic A, Iwantscheff S, Sonner JK, Grabitz C, Becker S, Böhler LI, Mohapatra SR, Sahm F, Küblbeck G, Nakamura T, Funakoshi H, Opitz CA, Wick W, Diem R, Platten M (2017)
Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis.
Sci Rep 7:41271
Stojic A, Fairless R, Beck SC, Sothilingam V, Weissgerber P, Wissenbach U, Gimmy V, Seeliger MW, Flockerzi V, Diem R, Williams SK (2017)
Murine Autoimmune Optic Neuritis Is Not Phenotypically Altered by the Retinal Degeneration 8 Mutation.
Invest Ophthalmol Vis Sci 58:318-328
Breckwoldt MO, Gradl J, Hähnel S, Hielscher T, Wildemann B, Diem R, Platten M, Wick W, Heiland S, Bendszus M (2017)
Increasing the sensitivity of MRI for the detection of multiple sclerosis lesions by long axial coverage of the spinal cord: a prospective study in 119 patients.
J Neurol 264:341-349
Sühs KW, Papanagiotou P, Hein K, Pul R, Scholz K, Heesen C, Diem R (2016)
Disease Activity and Conversion into Multiple Sclerosis after Optic Neuritis Is Treated with Erythropoietin.
Int J Mol Sci 17:pii: E1666.
Obert D, Helms G, Sättler MB, Jung K, Kretzschmar B, Bähr M, Dechent P, Diem R, Hein K (2016)
Brain Metabolite Changes in Patients with Relapsing-Remitting and Secondary Progressive Multiple Sclerosis: A Two-Year Follow-Up Study.
PLoS One 11:e0162583
Biller A, Pflugmann I, Badde S, Diem R, Wildemann B, Nagel AM, Jordan J, Benkhedah N, Kleesiek J (2016)
Sodium MRI in Multiple Sclerosis is Compatible with Intracellular Sodium Accumulation and Inflammation-Induced Hyper-Cellularity of Acute Brain Lesions.
Sci Rep 6:31269
Diem R, Molnar F, Beisse F, Gross N, Drüschler K, Heinrich SP, Joachimsen L, Rauer S, Pielen A, Sühs KW, Linker RA, Huchzermeyer C, Albrecht P, Hassenstein A, Aktas O, Guthoff T, Tonagel F, Kernstock C, Hartmann K, Kümpfel T, Hein K, van Oterendorp C, Grotejohann B, Ihorst G, Maurer J, Müller M, Volkmann M, Wildemann B, Platten M, Wick W, Heesen C, Schiefer U, Wolf S, Lagrèze WA (2016)
Treatment of optic neuritis with erythropoietin (TONE): a randomised, double-blind, placebo-controlled trial-study protocol.
BMJ Open 6:e010956
Sühs KW, Fairless R, Williams SK, Heine K, Cavalie A, Diem R (2014)
N-methyl-D-aspartate receptor blockade is neuroprotective in experimental autoimmune optic neuritis.
J Neuropathol Exp Neurol 73:507-18.
Davies AL, Desai RA, Bloomfield PS, McIntosh PR, Chapple KJ, Linington C, Fairless R, Diem R, Kasti M, Murphy MP, Smith KJ (2013)
Neurological deficits caused by tissue hypoxia in neuroinflammatory disease.
Ann Neurol 74:815–825
Fairless R, Williams SK, Hoffmann D, Stojic A, Hochmeister S, Schmitz F, Storch MK, Diem R (2012)
Preclinical retinal neurodegeneration in a model of multiple sclerosis.
J Neurosci 32:5585-97
Sühs KW, Hein K, Sättler MB, Görlitz A, Ciupka C, Scholz K, Käsmann-Kellner B, Papanagiotou P, Schäffler N, Restemeyer C, Bittersohl D, Hassenstein A, Seitz B, Reith W, Fassbender K, Hilgers R, Heesen C, Bähr M, Diem R (2012)
A randomized, double-blind, phase 2 study of erythropoietin in optic neuritis.
Ann Neurol 72:199-210
Williams SK, Fairless R, Weise J, Kalinke U, Schulz-Schaeffer W, Diem R (2011)
Neuroprotective effects of the cellular prion protein in autoimmune optic neuritis.
Am J Pathol 178:2823
Gadjanski I, Boretius S, Williams SK, Lingor P, Knöferle J, Sättler MB, Fairless R, Hochmeister S, Sühs KW, Michaelis T, Frahm J, Storch MK, Bähr M, Diem R (2009)
Role of N-type voltage-dependent calcium channels in autoimmune optic neuritis.
Ann Neurol 66:81-93
Diem R, Sättler MB, Merkler D, Demmer I, Maier K, Stadelmann C, Ehrenreich H, Bähr M (2005)
Combined therapy with methylprednisolone and erythropoietin in a model of multiple sclerosis. Brain 128:375-385
Sättler MB, Merkler D, Maier K, Stadelmann C, Ehrenreich H, Bähr M, Diem R (2004)
Neuroprotective effects and intracellular signaling pathways of erythropoietin in a rat model of multiple sclerosis.
Cell Death Differ 11 Suppl 2: S181-92
Diem R, Hobom M, Maier K, Weissert R, Storch MK, Meyer R, Bähr M (2003)
Methylprednisolone increases neuronal apoptosis during autoimmune CNS inflammation by inhibition of an endogenous neuroprotective pathway.
J Neurosci 23:6993-7000
Diem R, Meyer, Weishaupt JH, Bähr M (2001)
Reduction of potassium currents and phospatidylinositol 3-kinase-dependent AKT phosporylation by tumor necrosis factor-alpha rescues axotomized retinal ganglion cells from retrograde cell death in vivo.
J Neurosci 21:2058-66