WNT Signalling in Establishment of Neural Circuits and Embryonic Axis

Carl Matthias Carl

University of Heidelberg
Faculty of Medicine Mannheim
CBTM
Department of Cell and Molecular Biology
Ludolf-Krehl Strasse 13-17
D-68167 Mannheim

Phone:  +49 (0)621 383 9655
Fax:  +49 (0)621 383 9652
Email:  matthias.carl@medma.uni-heidelberg.de
Website:  http://www.zbio.org/research_carl_de.html

Research Summary

Every human can perform several tasks simultaneously. One reason for this multifunctionality is that the left and right brain hemispheres are used differentially. How and if these functional asymmetries correlate with morphological asymmetries found in the brain is still a fundamental question in neuroscience. To understand the neural wiring underlying multifunctionality we need to elucidate the genetic network important for their establishment. We use the zebrafish to elucidate the function of the Wnt/beta-catenin signalling in the establishment of neuroanatomical asymmetries in vivo.

A second aim of our research is the analysis of medakafish mutants that do not develop any trunk and tail structures. This unique phenotype is due to defective Wnt signalling in one of the mutants. Our analysis will help us understanding the conserved as well as species specific function of Wnt signalling during early events of patterning and morphogenesis important for posterior axis formation.

Structure of the group:

Group Leader:  Matthias Carl
   
PhD-Students:  Nesrin Mwafi, Alessio Paolini

 

Editor: A. Summerfield
Latest Revision: 2014-01-28
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