Pictures from the lab

Der Todesstern grosse Aufzuch in INF-364 is kapott.

(Klick auf's Bild öffnet große Ansicht in neuem Fenster)

Der-aufzuch-is-kapott

 


L.v.O. uses (and apparently likes) our new robotic pipetting system.

lvo pipetting fun


Dengue virus serotype 2 (strain 16681) causes visible plaques in Vero cells.

dengue plaques


Hochstapelei im Biolabor.

hochstapelei


March 2015: PhD Prize for Dr. Nitsche.

Dr. Christoph Nitsche received the PhD Prize of the section Medicinal Chemistry of the German Chemical Society (GDCh). Since 2010, Dr. Nitsche has worked in the group of Prof. Dr. Christian Klein on the development of dengue virus protease inhibitors. He identified inhibitors that reduce the replication of dengue viruses in cell culture.

 

preis 2

 

 


 

Synthese von Orangenlimonade. Man beachte den Nebel im Erlenmeyerkolben.

Zitat Dr. Nitsche: "Das ist noch richtige Chemie."

 

Nitro-orangenlimonade

 


A large molecule:

Molekuel in gross

 

Chemical biology:

chemical biology


​(Pictures drawn by Mrs. K. Klein)

 


Papa Smurf catalyzes a color change:

smurf0

smurf1
 

Reference:


​Erich Wünsch, Gert Fries, Anton Zwick
Darstellung und peptidsynthetische Verwendung von O-Benzyl-L-tyrosin

Aus dem Max-Planck-Institut fur Eiweiß- und Lederforschung, München

Zitat:
"Aus verd. Essigsäure ließ sich der Benzyläther in prächtigen Kristallen gewinnen."

Chem. Ber. 91, 542–547, 1958

 


Synthesis of a nasty but famous molecule. The tertiary alcohol is reported to smell horrible. The elimination product must not be assayed by organoleptic procedures.

mptp

 


 

Hot News: Niels Bohr visits Max Planck to discuss recent developments in quantum theory.
 
planck-bohr
 

(c) C. Klein


Mr. Joest purified a larger amount of MetAP from E. coli in complex with cobalt ions. The complex has a red-violet color, visible on the size exclusion column and in the protein concentrator.

ecmetap-on-column 
Ec-metap-in-concentrator
 
(c) C. Joest

Neue Malerei im Besprechungsraum.

granulozyten-bakterien-klein
 
Inspiriert von http://www.youtube.com/watch?v=OWUmXx5V_wE und gezeichnet von J. Klein.
 

A new project has started! TRP channel openers, obtained by really very green biotechnology. Picture from August 3rd:

trp-channel-1
 
 
Pictures from Oct. 4th - apparently there will be blossoms soon:
capsicum
 
 
Dec. 15th: Seems like some miniature chilies can be harvested before christmas.  Not bad for December.
ripening-chili
 

 

Copyright of the TRP channel project pictures: C. Klein 2013. Christian Joest kindly provided the genetic material necessary for this study.


Mr. Joest has a new favorite reaction: Birch reduction.

The apparatus:

setup
 
 
Lots of dry ice are needed:
 
dry-ice
 

 

 
 
About 900 ml of liquid ammonia:
 
nh3
 
 
For some reason (?) Mr. Joest prefers to use lithium instead of the more reactive alkali metals:
 
lithium
 

Solvated electrons in a turbulent flow:

solvated-electrons
 

Surplus lithium precipitates from NH3:

li-prec
 

Ammonia has a very high heat capacity. Therefore, evaporation of this substantial amount of liquid ammonia takes several hours.

Copyright of the Birch reduction pictures: Christian Joest, 2013.


This is what happens when you store open (!) vials with diethyl ether (!) in a fridge that is not protected (!) against explosions.

The event DID NOT occur in the labs of the Klein group, but CK was there to put out the ensuing fire, which took three large fire extinguishers. Fortunately, nobody was hurt.

rumms4
 

Copyright of the molten fridge picture: Christian Klein, 2013.


Waidmannsheil for Mrs. Weigel et al.:

maus
 

Copyright of the mouse picture: Sarah Calcagno, 2013.

Note: This is a wild mouse that was caught, without causing any harm, in the lab. The mouse now lives in the botanical garden, across the street from INF-364. We do not perform animal experiments.


Medieval painting found in the meeting room:

prehistoric
 

Copyright of the medieval painting picture: Christian Klein, 2013.

 



 

 

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