Pictures from the lab
Todesstern grosse Aufzuch in INF-364 is kapott.
(Klick auf's Bild öffnet große Ansicht in neuem Fenster)
L.v.O. uses (and apparently likes) our new robotic pipetting system.
Dengue virus serotype 2 (strain 16681) causes visible plaques in Vero cells.
Hochstapelei im Biolabor.
March 2015: PhD Prize for Dr. Nitsche.
Dr. Christoph Nitsche received the PhD Prize of the section Medicinal Chemistry of the German Chemical Society (GDCh). Since 2010, Dr. Nitsche has worked in the group of Prof. Dr. Christian Klein on the development of dengue virus protease inhibitors. He identified inhibitors that reduce the replication of dengue viruses in cell culture.
Synthese von Orangenlimonade. Man beachte den Nebel im Erlenmeyerkolben.
Zitat Dr. Nitsche: "Das ist noch richtige Chemie."
A large molecule:
(Pictures drawn by Mrs. K. Klein)
Papa Smurf catalyzes a color change:
Erich Wünsch, Gert Fries, Anton Zwick
Darstellung und peptidsynthetische Verwendung von O-Benzyl-L-tyrosin
Aus dem Max-Planck-Institut fur Eiweiß- und Lederforschung, München
"Aus verd. Essigsäure ließ sich der Benzyläther in prächtigen Kristallen gewinnen."
Chem. Ber. 91, 542–547, 1958
Synthesis of a nasty but famous molecule. The tertiary alcohol is reported to smell horrible. The elimination product must not be assayed by organoleptic procedures.
(c) C. Klein
Mr. Joest purified a larger amount of MetAP from E. coli in complex with cobalt ions. The complex has a red-violet color, visible on the size exclusion column and in the protein concentrator.
Neue Malerei im Besprechungsraum.
A new project has started! TRP channel openers, obtained by really very green biotechnology. Picture from August 3rd:
Copyright of the TRP channel project pictures: C. Klein 2013. Christian Joest kindly provided the genetic material necessary for this study.
Mr. Joest has a new favorite reaction: Birch reduction.
Solvated electrons in a turbulent flow:
Surplus lithium precipitates from NH3:
Ammonia has a very high heat capacity. Therefore, evaporation of this substantial amount of liquid ammonia takes several hours.
Copyright of the Birch reduction pictures: Christian Joest, 2013.
This is what happens when you store open (!) vials with diethyl ether (!) in a fridge that is not protected (!) against explosions.
The event DID NOT occur in the labs of the Klein group, but CK was there to put out the ensuing fire, which took three large fire extinguishers. Fortunately, nobody was hurt.
Copyright of the molten fridge picture: Christian Klein, 2013.
Waidmannsheil for Mrs. Weigel et al.:
Copyright of the mouse picture: Sarah Calcagno, 2013.
Note: This is a wild mouse that was caught, without causing any harm, in the lab. The mouse now lives in the botanical garden, across the street from INF-364. We do not perform animal experiments.
Medieval painting found in the meeting room:
Copyright of the medieval painting picture: Christian Klein, 2013.