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Lazaro Centanin PhD

Current Research

Organ Size Control and Lineage Organization of the Fish Eye.

My main interest is how the eye of the fish grows. I am particularly focused on studying how the neural stem cells of the retina can create every single mature cell type -neurons and glia. I study that process using both inducible over/miss-expression methods and mutants with phenotypes in the proliferative zone of the eye.


Retina 7dpf Medaka

"Retina of a 7dpf Medaka, showing retinal progenitor in red at the margins of the eye, and adjacent newly generated neurons in green".!













Publication List


- Central role of the oxygen-dependent degradation domain of Drosophila HIFalpha/Sima in oxygen-dependent nuclear export.
Irisarri M, Lavista-Llanos S, Romero N, Centanin L, Dekanty A, Wappner P.
Mol Biol Cell. 2009 Sep;20(17):3878-87.

- Tracheal remodelling in response to hypoxia.
Centanin L, Gorr TA, Wappner P.
J Insect Physiol. 2009 Jun 10.

- Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting.
Centanin L, Dekanty A, Romero N, Irisarri M, Gorr TA, Wappner P.
Dev Cell. 2008 Apr;14(4):547-58.

- Cloning of hif-1alpha and hif-2alpha and mrna expression pattern during development in zebrafish.
Rojas DA, Perez-Munizaga DA, Centanin L, Antonelli M, Wappner P, Allende ML, Reyes AE.
Gene Expr Patterns. 2007 Jan;7(3):339-45.

- Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxia-inducible factor-alpha/Sima.
Centanin L, Ratcliffe PJ, Wappner P.
EMBO Rep. 2005 Nov;6(11):1070-5.

- Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar.
Lavista-Llanos S, Centanin L, Irisarri M, Russo DM, Gleadle JM, Bocca SN, Muzzopappa M, Ratcliffe PJ, Wappner P.
Mol Cell Biol. 2002 Oct;22(19):6842-53.


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Latest Revision: 2014-05-21