Prof. Dr. Peter Lichter

Fellow-Klasse 2011-12

Forschungsgebiete:

Pathomechanismen der Ätiologie und Ausbreitung menschlicher Tumoren; Prognostische und prädiktive molekulare Marker und Signaturen in der Onkologie; Entwicklung von Strategien für molekulare Therapien in der Onkologie; Räumliche und dynamische Organistion der Genominformation in Zellen; Methoden der Genomik und Epigenetik

Curriculum Vitae

Arbeitsvorhaben

Ausgewählte Publikationen:

• Lichter, P., Tang, C.C., Call, K., Hermanson, G., Evans, G.A., Housman, D., Ward, D.C. (1990) High resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. Science 247, 64-69.
• Lichter, P., Cremer, T., Borden, J., Manuelidis, L., Ward, D.C. (1988) Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using chromosome specic library probes. Hum. Genet. 80, 224-234.
• Döhner, H., Stilgenbauer, S., Benner, A., Leupolt, E., Kröber, A., Bullinger, L., Döhner, K., Bentz, M., Lichter, P. (2000) Genomic aberrations predict survival of patients with B-cell chronic lymphocytic leukemia. New Engl. J. Med. 343, 1910-1916.
• Solinas-Toldo, S., Lampel, S., Stilgenbauer, S., Nickolenko, J., Benner, A., Döhner, H., Cremer, T., Lichter, P. (1997)  Matrix-based comparative genomic hybridization: Biochips to screen for genomic imbalances. Genes Chromosom. Cancer 20, 399-407.
• Schwaenen, C., Nessling, M., Wessendorf, S., Salvi, T., Wrobel, G., Radlwimmer, B., Kestler, H.A., Haslinger, C., Stilgenbauer, S., Döhner, H., Bentz, M., Lichter, P. (2004) Automated array based genomic proling in chronic lymphocytic leukemia: Development of a clinical tool and discovery of recurrent genomic alterations. Proc. Natl. Acad. Sci. USA 101, 1039-1044.
• Mendrzyk, F., Radlwimmer, B., Joos, S., Kokocinski, F., Benner, A., Stange, D.E., Neben, K., Fiegler, H., Carter, N.P., Reifenberger, G., Korshunov, A., Lichter, P. (2005) Genomic and protein expression proling identies CDK6 as novel independent prognostic marker in medulloblastoma. J. Clin. Oncol. 23, 8853-8862.
• Thuerigen, O, Schneeweiss, A., Toedt, G., Warnat, P., Hahn, M., Kramer, H., Brors, B., Rudlowski, C., Benner, A., Schuetz, F., Tews, B., Eils, R., Sinn, H.-P., Sohn, C., Lichter, P. (2006) Gene expression signature predicting pathologic complete response to primary systemic chemotherapy with gemicitabine, epirubicin and docetaxel in primary breast cancer. J. Clin.
  Oncol. 24, 1839-1845.
• Weber, R.G., Boström, J., Wolter, M., Baudis, M., Collins, V.P., Reifenberger, G., Lichter, P. (1997) Analysis of genomic alterations in benign, atypical and anaplastic meningiomas: Towards a genetic model of meningioma progression. Proc. Natl. Acad. Sci. USA 94, 14719-14724.
• Mertens, D., Wolf, S., Tschuch, C., Mund, C., Kienle, D., Ohl, S., Schroeter, P., Lyko, F., Döhner, H., Stilgenbauer, S., Lichter, P. (2006) Allelic silencing at the tumor suppressor locus 13q14.3 suggests an epigenetic tumor suppressor mechanism. Proc. Natl. Acad. Sci. USA 103, 7741-7746.
• Pfister, S., Janzarik, W.G., Remke, M., Ernst, A., Werft, W., [weitere 17 Personen, Kürzung TJ aus technischen Gründen], Lichter, P. (2008) BRAF gene duplication constitutes a novel mechanism of MAPK pathway activation in low-grade astrocytomas. J. Clin. Invest. 118,1739-1749.